Biomedical subjects
J McSweeney
Publications and source records attributed to J McSweeney.
Maternal plasma beta-hCG in early human pregnancy.
Beta-human chorionic gonadotrophin (beta-hCG) was assayed twice weekly in plasma from 20 subjects from 4 to 16 weeks gestation; 14 of these were normal. There was an initial rise, a plateau at weeks 7 to 9, and a further rise to a maximum at week 11. Levels then dropped steadily to week 16. There was no significant difference when mean levels were subdivided and calculated according to the subsequent sex of the baby. Of the 6 abnormal subjects, the twin pregnancy initially showed normal levels but at week 11 to 13 these were at least one standard deviation above the mean. The plasma beta-hCG levels of the two subjects who aborted were more than one standard deviation below the mean at week 5. Three subjects treated with progestogen therapy had beta-hCG levels which fluctuated within normal limits. The trends of beta-hCG levels were similar to those of plasma hCG levels in the two subjects who had both assays performed but peak times were different. There was considerable within patient and also patient to patient variation in beta-hCG levels.
Idiopathic infertility: a trial of bromocriptine versus placebo.
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Stress, prolactin, and infertility.
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Angiographic investigation of retroperitoneal space.
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Schistosomiasis japonica of liver.
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Hemobilia complicating needle liver biopsy. A case report with arteriographic demonstration.
Massive hemobilia secondary to a needle liver biopsy developed in a 16-year-old boy with Hodgkin's disease. Cholecystectomy and common bile duct drainage failed to control the condition and the patients bled massively; management of the hemobilia was effected with left hepatic artery ligation. A review of the literature is presented, with a brief discussion of the clinical picture, pathophysiology, diagnosis, and management of this condition.
Arteriography of peripheral hemangiomas.
Arteriography has proved useful in evaluation of 17 patients with peripheral soft-tissue hemangiomas (15 benign, 2 malignant) by defining their extent, degree of vascularity, and source of vascular supply and allowing differentiation from arteriovenous malformations. In 11 cases (all benign), moderate fine-caliber hypervascularity with some degree of staining was seen. In 6 (4 benign, 2 malignant) there was marked hypervascularity with coarse, irregular vessels. The coarse or fine hypervascularity which characterizes most benign hemangiomas closely resembles that seen in malignant soft-tissue tumors and may preclude correct diagnosis by angiography alone. However, peripheral hemangiomas frequently exhibit distinctive clinical features which when combined with the arteriographic findings enable the radiologist to identify the lesion.
The use of spermatic cord lymphatics in the relief of surgically created lower extremity edema. A preliminary report of experiments in dogs.
When lower extremity lymphedema is not amenable to control by medical methods, attempts to ameliorate the problem surgically have generally been unsatisfactory. The intact testis and spermatic cord provide a potential bridge that may permit communication between the unobstructed lymphatics of the gonadal system and the obstructed lymphatics of the lower extremity. Preliminary experience in male dogs wherein lower extremity lymphedema is first induced surgically and is treated by testicular implantation into the edematous thigh shows that lympholymphatic communications between the lower extremity and the gonadal system may result.
Therapeutic transluminal arterial embolization for bleeding in the upper part of the gastrointestinal tract.
Diagnosis and the treatment of gastrointestinal bleeding by selective and superselective technique and the perfusion of vasopressors have been noted to have significant success. Transluminal embolization of a bleeding site represents an alternative method in patients who represent a poor operative risk and in those in whom vasopressor therapy has failed. The potential risks include intestinal ischemia and vary with the anatomic site.
Tumors of the liver as demonstrated by angiography, scan and laparotomy.
One hundred and eighteen patients with various hepatic tumors proved by laparotomy have been analyzed for accuracy and for pitfalls of preoperative studies, namely, physical examination, celiac and superior mesenteric angiography and liver scan. Angiography is correct in detecting a hepatic tumor in 93 per cent and scan, in 87 per cent, overall. When angiography and scan are combined, tumors are detected in 97 per cent of patients. As for specific location and extent of the hepatic tumor to determine its resectability, angiography is correct in 75 and scan in 62 per cent, over-all. Eleven of 39 resectable tumors were deemed nonresectable in preoperative studies. Although angiography and scan are the best available means of diagnosing hepatic tumors, presently, true resectabilty of hepatic tumors can be determined only be exploratory examination.
Secondary neoplasms of the bowel.
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