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Biomedical subjects

J Mcdonald

Publications and source records attributed to J Mcdonald.

8 recordsLinked to original sources
PubMed2001

Training status influences T-cell responses in women following acute resistance exercise.

The purpose of this investigation was to examine white blood cell counts (WBC), immunoglobulin (IgA, IgG, IgM) levels, and T-cell proliferation following acute resistance training in 9 untrained (UT) and 6 trained (TR) women. Resistance training on 7 Universal machines at the subject's 10 repetition maximum (IORM) was performed at 89 +/- 5% for UT and 88 +/- 3% for TR. Blood was analyzed for WBCs and Ig levels pre-exercise, immediately postexercise, and 1.5, 3, and 24 hours postexercise. T-cell proliferation was determined pre-exercise and 3 hours postexercise through response to phytohemagglutanin (PHA). WBCs were significantly elevated in the UT subjects 1.5 and 3 hours postexercise compared with pre- and immediately postexercise; no differences (p < 0.05) were observed in TR subjects. No significant differences were found for Ig levels either between or within groups, although there was a trend for decreased IgG following exercise. T-cell proliferation was significantly decreased in the UT at 3 hours postexercise (0.27 +/- 0.06 units) compared with pre-exercise (0.41 +/- 0.06 units), whereas the proliferative response in TR was not significantly different from pre-exercise (0.48 +/- 0.04 units) to 3 hours postexercise (0.34 +/- 0.06 units). These data indicate that UT subjects experience an increase in WBC counts and a decrease in T-cell proliferative ability after acute resistance training, whereas TR subjects experience no significant change in these parameters.

Adult↗
PubMed1998

Workers for Australia: a profile of British and Irish migrants assisted to New South Wales in 1841.

"This profile of 20,000 British and Irish assisted migrants [to Australia after 1841], based on individual-level data, establishes their age, sex, religious, educational and occupational characteristics. Their composition differed markedly from the existing colonial population and other migrant flows at the time. They reflected the recruiting methods of the time as well as the changing migration propensities in the British Isles. The migrants were better human capital than was acknowledged at the time. They constituted a new start in Australian demographic development."

Age Distribution↗
PubMed1988

Acceleration of growth rate in growth hormone-deficient children treated with human growth hormone-releasing hormone.

Twenty-four growth hormone-deficient children were treated with growth hormone releasing hormone-40 (GHRH) for 6 months or longer. GHRH (1 to 4 micrograms/kg of body weight per dose) was administered subcutaneously every 3 h (n = 10); or every 3 h overnight only (n = 10); or by twice daily injections (n = 4). Twenty-one children had an increase in growth rate during GHRH treatment. The growth velocities (mean +/- SD; cm/yr) before and during treatment were, respectively: every 3 h 3.5 +/- 1.4 versus 10.0 +/- 2.2, p = 0.0001; overnight only 3.4 +/- 1.0 versus 6.2 +/- 2.1, p = 0.008; twice daily injections 3.2 +/- 1.8 versus 7.9 +/- 2.4, p = 0.06. Using these three modes of GHRH administration, different total daily amounts of GHRH were administered. Regression analysis of average daily dose versus growth velocity revealed a correlation coefficient (r) value of 0.57, p = 0.004. Sixteen children received extended treatment for periods varying from 9 to 30 months. Of these, seven children were treated continuously for 9 months with pump overnight only and 5 for 12 months with pump every 3 h. Their growth velocities were sustained at a similar rate as those observed at 6 months. Six children received both twice daily and three hourly treatments consecutively. The growth velocities were similar during both treatments. Eleven children developed circulating antibodies to GHRH during treatment, however, all 11 had accelerated growth rates during GHRH therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1981

Forecasting Australian marriage rates.

"The paper discusses the problem of modelling demographic variables for the purpose of forecasting. Two empirical model selection procedures are applied to suggest final form forecasting equations for Australian marriage rates. The suggested models are then assessed by comparing their post-sample forecast performance with that of univariate ARMA-type models of marriage rates which are regarded as approximations to marriage rate final equation models. In this instance the ARMA models are preferred for forecasting purposes. The properties of the ARMA model forecasts are then examined and the modelling strategy is contrasted with the regression method used by Withers."

Australia↗
PubMed1980

Correlation of sperm granulomas and sperm autoantibodies in inbred rats.

The relationship between sperm granulomas and antisperm antibodies is speculative. Some investigators believe that sperm granulomas are the result of humoral sensitization, whereas others doubt that they represent an immunologic phenomenon at all. We performed transabdominal bilateral vasectomies by ligation or transection in Brown Norway, Lewis, Fischer, and Sprague-Dawley rats. These strains are known to differ in incidence of antisperm antibody formation following vasectomy. Serum was obtained monthly for determination of antibodies by indirect immunofluroescence. Animals were killed at 6 months and examined for the presence of antisperm antibodies and sperm granulomas. Both antibodies and granulomas were found in 71% of Brown Norway rats. Granulomas were found in all rats of other strains, whereas the incidence of antibodies ranged from 25% to 50%. Thus a specific immunologic relationship between sperm granulomas and antisperm antibodies has not been confirmed.

Animals↗