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Biomedical subjects

J Meier-Sydow

Publications and source records attributed to J Meier-Sydow.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Guinea-pig asthma (author's transl)].

Out of 140 selected patients with bronchial asthma 24 demonstrated signs of guinea-pig hypersensitivity. Six further patients with a shorter exposure to guinea-pigs were not sensitized. The diagnosis can be established by means of history, skin test, and removal of the animal. The mean period until asthma became clinically manifest was 12.3 months, for the prodromal stage rhinitis and (or) conjunctivitis 9.8 months. Atopic symptoms may or may not be present in affected persons. A great number of accompanying false-positive skin test reactions to different animal dander antigens supports the hypothesis of an antigenic relationship between dander allergens from different animal species. The only treatment for guinea-pig asthma is removal of the guinea-pig. Other domestic animals should be avoided as well.

Allergens↗
PubMed1976

[Frequency and correlative relation of diagnostic criteria in animal dander allergy].

355 out-patients with signs of bronchial asthma were studied with special reference to animal dander sensitization. Case histories allowed the clinical diagnosis of an allergy to animal dander in 75 patients (21.1%). Skin testing is a useful means, as large reactions appear in most cases of animal dander allergy (60.7% are greater than or equal to + + + -reactions). Skin reactions, however, often are "false positive" or "false negative". Therefore, bronchial provocation tests are necessary if the case history is doubtful and/or the skin reaction is less than a + + + -reaction. There is a positive correlation between skin reaction and bronchial provocation test. No negative inhalation tests were seen when the skin reaction was greater than + + +. However, a positive inhalation test can be correlated with a negative or weakly positive skin test. The probability of common structural properties of different mammalian dander allergens is discussed. Avoidance of exposure to the animal is recommended as the therapy of choice.

Allergens↗
PubMed1976

[Bronchial antigen provocation tests with the use of whole body plethysmography].

Bronchial provocation tests are performed in order to reproduce the symptoms of extrinsic bronchial asthma. The bronchial obstruction induced hereby can be demonstrated by plethysmographic measurement of specific airway resistance, which is superior to spirometric parameters with regard to sensitivity and effort independence. A rise of specific airway resistance above 20 cmH2O X sec ("dyspnoea threshhold") can be used as the criterium of a positive result. In contrast to forced expiratory manoeuvres no spirometry induced asthma can occur. Automatic evaluation by electronic data processing is possible.

Aerosols↗