Biomedical subjects
Publications and source records attributed to J Meissner.
In 66 cases of carcinoma of the breast the estradiol receptors was determined and in 16 cases the progesterone receptor additionally, too. This was done in order th decide about endocrine therapy. The results of estrogen and progesterone receptors estimations were compared and correlated both the type of carcinoma and the degree of its histologic differentiation.
In this paper results in diagnostics and therapy are presented of 185 patients with breast diseases obtained during special consultation hours. The greatest part of the breast diseases are fibrocystic mastopathies. Very good therapeutic results have been achieved using the phytotherapeutic agent Mastodynon. Emphasis is laid on the increasing importance of the histological findings and hormon receptor determination.
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In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate on basal and GnRH stimulated gonadotropin secretion was investigated. The investigation were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. LH and FSH serum levels were determined by RIA. Under treatment a suppression both of basal gonadotropin serum levels and of the stimulated LH secretion results. After treatment the mean basal gonadotropin levels are higher than before or during the therapy. The LH release after GnRH stimulation shows the same trend.
Estradiol-17 beta, progesterone, LH and FSH levels in plasma were measured simultaneously by radioimmunoassay and BBT was recorded in order to investigate the effect of a single midcycle oral dose of 0.5 or 2.0 mg dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one, VEB Jenapharm, Jena/GDR) on pituitary and ovarian function in 18 healthy fertile females. After application of 0.5 mg dienogest in the follicular phase the cycles appeared to be anovulatory. Administration of 2.0 mg two days prior to the expected LH-surge produced a delay of the LH-peak combined with an absence of ovulation as well as the absence of the normal subsequent increase of progesterone. With 0.5 mg the delay of the LH-surge was followed by an ovulation with normal corpus luteum function. The application of 0.5 or 2.0 mg one day before or during the rising LH-peak lowered the LH-surge but ovulation and luteal phase were not altered. Administration of both dosages during the LH-peak could neither prevent ovulation nor disturb corpus luteum function. Postovulatory ingestion of 0.5 or 2.0 mg dienogest during the BBT-rise produced no alteration of the further cycle. These results demonstrate that dienogest in a single-dose-administration in midcycle can alter pituitary and ovarian function depending on the time interval between application and the day of LH-surge.
A report is given about one case of ectopic pregnancy after in vitro fertilization and transfer of three embryos. Possible causes of ectopic pregnancies following embryo transfer and conclusions are discussed.
Investigation of the immunoglobulins in the vaginal lavage fluids are semiquantitatively. The aim of the present study was to complete the semiquantitative S-IgA estimations with an "S-IgA/IgA" ratio. An antiserum against the secretory component (Anti-SC) and an S-IgA standard as well as an antiserum against the immunoglobulin A(Anti-IgA) and a serum IgA standard were used. The ratio was proved in vaginal lavage fluids from 5 fertile and 2 infertile women in the course of the menstrual cycle on days 8th, 11th, 14th, 18th and 24th. Progesterone, IgG and IgA were estimated simultaneously in serum samples. According to the "S-IgA/IgA" ratio patients were divided in 2 groups with values higher than 1 on the one side and with values lower than 1 on the other side. In cases with high "S-IgA/IgA" ratio an increased local antibody production and secretion is supposed.
Retroplacental blood samples were received after vaginal deliveries from 22 healthy primi- and multiparae aged between 20 and 30 years. Simultaneously venous blood samples were taken immediately after delivery. Pregnancy specific beta 1-glycoprotein (SP1), pregnancy associated alpha 2-glycoprotein (PZ), immunoglobulins G, M, A, secretory immunoglobulin A (S-IgA), alpha 2-macroglobulin (AMG) and unconjugated estriol were estimated quantitatively in venous as well as in retroplacental blood samples. The concentrations of SP1 in retroplacental blood were significantly lower compared with concentrations in venous blood, whereas estriol concentrations were significantly higher in retroplacental blood. All other factors differed not significantly. Only the IgM concentrations correlated in venous and retroplacental blood samples. The percentages of estimated proteins related to total protein content showed similar proportions in venous as well as in retroplacental blood. The relative protein content of SP1 was significantly lower in retroplacental blood than venous blood samples. The percentage of PZ was significantly higher in retroplacental blood. Among other things these increased concentrations of estriol and PZ in retroplacental blood be able to prevent the rejection of the trophoblast by the maternal endometrium.
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Secretory immunoglobulin A (S-IgA) is an essential part of local immune system of female genital tract. Accordingly the estimation of S-IgA in female genital secretions is important for judgement of immunologic problems in female genital tract. The estimation of S-IgA was carried out by means of an antiserum against human secretory component (anti SC) and S-IgA standard. It was used the single radial immunodiffusion according to Mancini and co-workers. Our results refer to changes in the quantity of S-IgA locally produced in the mucous membranes of female genital tract correlated to the menstrual cycle. The essential results are a decrease of S-IgA in midcycle in cervical mucus and vaginal fluids as well as of fertile and sterile patients.
In a 12 years old patient with asymmetric mixed gonadal dysgenesis (karyotype 45, XO/46,XY) a stimulation test with arginine, gonadotropin-releasing hormone (GRH) and thyreotropin-releasing hormone (TRH) was performed before and after exstirpation of the gonads as well as after application of sex steroids. FSH, LH, PRL, HGH, TSH, testosterone and oestradiol were determined by radioimmunoassay. The results show an intact hypothalamo-pituitary axis which reacts with a normal negative feedback with respect to the secretion of gonadotropins after application of sex steroids.
The excretion of the C19O2-fraction of 17-oxosteroids in urine (C) and the concentration of testosterone in serum (T) have been compared in 15 women with hirsutism during tests with suppression of the adrenals and the ovary and with stimulation of the ovary. The behaviour of both parameters seemed to be only qualitatively similar in all three phases of the tests. In one of the test phases a statistically significant correlation between the percentage of decrease or increase of C and T has been observed (First phase: r = 0.242; second phase; r = 0.457; third phase r = 0.392). The mean relative changes of C in the adrenal suppression phase was more distinct (P less than 0.002) than that of T. Both parameters seem to be of different diagnostic meaning.
Serial serum concentrations of phenprocoumon were measured in 2 female patients who had taken 150 and 450 mg of the drug in suicidal attempts. In one case absorption of phenprocoumon took nearly two days. At a concentration of 1.7 and 1.8 microgram/ml the elimination curve showed a notch in both patients. Above this concentration half life was 97.7 and 95.9 hours, below these levels 134.4 and 155.5 hours. In-vitro binding investigations with serum of a healthy proband showed an increase of the non-bound drug by 56.6% at a phenprocoumon concentration of 0.5-25.34 micrograms/ml. As no notch could be observed at lower concentrations the notch in the elimination curve cannot be explained by concentration-dependent plasma binding of the anticoagulant. In-vitro experiments involving haemodialysis indicate that the letter cannot be recommended for treatment of phenprocoumon intoxication as the amount of phenprocoumon thus eliminated from the body is minimal. Both patients survived the phenprocoumon intoxication without damage. They were only treated with vitamin K.
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The release of 35S labeled corneal glycoprotein from an allogenic interlamellar corneal graft was studied in randomly selected rabbits. Simultaneously, the uptake of 35S by the recipient animal was investigated. These changes followed for a period of 80 h indicate that there is a constant 35S release fromthe donor cornea and that it is the recipient cornea which takes up the major part of the 35S from the donor. The iris, choroid, and sclera of the recipient also take up a certain percentage of the donor's 35S while the aqueous humor, the optic nerve, and the local lymph nodes take up only minimal amounts.
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Explore the source record for details and available documents.