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Biomedical subjects

J Mellinger

Publications and source records attributed to J Mellinger.

15 recordsLinked to original sources

Patients with ALS can use sensorimotor rhythms to operate a brain-computer interface.

People with severe motor disabilities can maintain an acceptable quality of life if they can communicate. Brain-computer interfaces (BCIs), which do not depend on muscle control, can provide communication. Four people severely disabled by ALS learned to operate a BCI with EEG rhythms recorded over sensorimotor cortex. These results suggest that a sensorimotor rhythm-based BCI could help maintain quality of life for people with ALS.

Aged↗

Resident and faculty perceptions of a surgical residency program merger.

To evaluate resident and faculty perceptions of a residency merger process.Survey of faculty and residents of a recently merged general surgical residency. Nineteen separate program characteristics were evaluated via a numerical scoring system, and additional written commentary regarding dominant perceived benefits and detriments of the merger was solicited. Statistical significance was evaluated on numerically scored items by applying the Mann-Whitney U test to median values expressed with interquartile ranges, comparing resident and faculty responses.Scoring system responses from faculty and residents were generally similar. The merger was seen as neutral to positive in its impact on academic issues, but it had more negative effects on issues related to overall program atmosphere and morale. Statistically significant differences between resident and faculty responses were noted in 2 areas: teaching conference timing and overall program effectiveness in preparing for practice. Both of these areas were more favorably impacted by the merger from the residents' perspective, and more negatively as judged by the faculty (p < 0.05). Written commentary by both groups similarly emphasized areas of academic strengthening as a positive effect of the merger, and relationship and morale issues as being more negatively impacted.As reflected by resident and faculty perceptions, program mergers may provide opportunities to strengthen and enhance the academic and clinical foundation of residency. This may, however, occur at the expense of morale and relational issues, which may be negatively impacted by program administrative and geographic expansion.

Journal Article↗

Cost-effectiveness of laparoscopic cholecystectomy.

This study retrospectively evaluated the cost-effectiveness of laparoscopic cholecystectomy compared to open cholecystectomy in a single university-affiliated community hospital. The medical records of all patients that underwent laparoscopic cholecystectomy during 1990 and open cholecystectomy during 1989 in one hospital were reviewed. Hospital stay, hospital charges, surgeons' and anesthesiologists' fees were determined. Fifty patients from each group were contacted to determine recovery time to full activity after surgery. Those having common duct exploration and those converted to open cholecystectomy after an attempted laparoscopic cholecystectomy (n = 8) were excluded. A summary of results is included below (Table 1). In our early experience with laparoscopic cholecystectomy we found that the total charges for laparoscopic cholecystectomy were more than for open cholecystectomy when one recognizes the 1-year difference in patient accrual between the two groups. Time to full recovery was markedly reduced in patients undergoing laparoscopic cholecystectomy compared to those having an open procedure. Despite the overall increased total charge with laparoscopic cholecystectomy, the shorter recovery period allowing the patients an earlier return to full preoperative activities contributes to its cost-effectiveness when compared to open cholecystectomy. Further experience with laparoscopic cholecystectomy and refinements in management of these patients should allow for further reductions in charges for this procedure.

Analysis of Variance↗

[Chronologic, structural and biometric study of the egg and its development of the small spotted dogfish (Scyliorhinus canicula) raised in artificial seawater].

The eggs of the small spotted dogfish (Scyliorhinus canicula), developed in artificial sea water at 14 degrees C, pre-hatched after 3 to 3 1/2 months (total embryo length: 31 to 38 mm). Hatching occurred after 6 1/2 to 7 1/2 months (length of newborn: 80 to 95 mm). Egg weight first increased for 12 days and then remained constant until pre-hatching. A biometric study of the whole egg, egg case and albumen chamber showed very little variation in egg width, while egg length varied widely. As laying occurs in pairs, the secretory activity in each nidamental gland was observed to adapt to the extra volume of egg case contents in two cases where a double egg was laid with a normal one. However, the size and shape of the normal eggs of each female were generally distinctive, regardless of the contents or the external conditions. The egg case wall had three separate layers, as shown by microscopy of fresh material and experimental studies with various dyes.

Animals↗

Pregnancy rate in dairy cows inseminated on the basis of electronic probe measurements.

A new vaginal probe with two pairs of parallel electrodes 90 degrees apart was designed with a switching arrangement so that electrical resistance (ohms) of the dorsal and the ventral areas of the anterior vagina could be monitored separately during the estrous cycle. Three inseminators probed cows during February--April, 1977, in nine herds in stanchion barn housing. Cows not seen in estrus by 40 to 60 dyas after calving were probed every 3rd day. At each dairyman's option normal cows with a low porbe reading were inseminated. Controls consisted of cows seen in estrus by the dairyman and reported for insemination in the routine manner. The diagnosed pregnancy rate for 86 first service controls was 49% versus 52% for 58 cows not seen in estrus, but identified by low probe readings. Cows varied in electrical resistance at breeding, but the fact that pregnancy rates were equivalent in the two groups is interpreted to mean that the probe was as effective in identifying cows suitable for insemination as was visual observation of estrus by dairymen.

Animals↗

[Electron microscope observation of "thyroidectomy cells" in the hypophyseal ventral lobe of a Chondrichthyan fish, the small spotted dogfish, Scyllium canicula Cuv].

In the adenohypophysis of very young spotted dogfish, only one kind of granulated cells show strcutural changes following thyroidectomy: the small granule cells of the ventral lobe (granule diameter about 110 nm). These cells are similar to the thyrotrophs of other Vertebrates, and well distinct from the supposed gonadotrophs found in the same lobe.

Animals↗

Colonoscopic indirect lymphangiography in a canine model.

Colorectal malignancies metastasize most frequently to mesenteric lymph nodes. Preoperative staging of these nodes by current modalities is problematic. This study evaluates the feasibility of indirect mesenteric lymphangiography as a colonoscopic technique in a canine model. Ten mongrel dogs underwent endoscopic submucosal injection of Ethiodol at various sites in the transverse, descending, and rectosigmoid areas. Serial abdominal roentgenograms were obtained up to 2 weeks postinjection. In seven of the animals, demonstration of mesenteric nodal uptake corresponding to the area(s) of injection was radiographically documented. In the remaining animals (early in the series) nodal opacification was inadequate. This lack of nodal uptake appeared to be due to nonsubmucosal contrast injection. No complications were noted. Colonoscopic indirect lymphangiography appears to be a safe and potentially useful modality in the evaluation of mesocolonic lymph nodes. Further studies to refine this technique and investigate its potential to preoperatively delineate abnormal nodal architecture are warranted.

Animals↗

[Biology and physiology of development, growth and reproduction of electric rays. Survey of research since 1965].

Since 1965, various works have pointed to electric rays (chiefly Torpedo marmorata and T. torpedo = T. ocellata) as an interesting material for the biological and physiological research on development (especially that of electric organs), growth and reproduction. In a review of the main published results, attention is called upon several points requiring new studies (buoyancy and its regulation during gestation time, neuroendocrine control of gestation, etc.). T. torpedo, a much abundant species in the Bay of Tunis, seems by far the most well-suited material for this, because of its annual reproductive cycle. New results concerning T. m. are also presented: gestation length, embryo retention, and weight changes of the yolk sacs. The microscopic structure of the female genital tract is illustrated.

Aging↗