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Biomedical subjects

J Menczer

Publications and source records attributed to J Menczer.

At least 73 records · Page 4Linked to original sources
PubMed1991

Cystotomy--for facilitation of optimal resection of adherent pelvic tumors.

Optimal resection of pelvic tumor was facilitated by cystotomy in one patient with a benign and five patients with malignant adherent pelvic tumors. Four of the five patients with malignant tumors had recurrent or persistent carcinoma of the ovary. Blood loss and surgical duration were acceptable and there were no postoperative complications. Cystotomy is a relatively easy and safe procedure and is recommended when optimal resection of adherent pelvic tumor is attempted.

Female↗
PubMed1991

Familial ovarian cancer in Israeli Jewish women.

Among 310 women with ovarian cancer of epithelial origin, eight ovarian cancer-prone families were identified, accounting for 24 cases. Five first-degree relatives underwent prophylactic oophorectomy, and early ovarian carcinoma was diagnosed in one of them. Familial aggregation of ovarian cancer occurs in the Israeli Jewish population.

Female↗
PubMed1991

Midtrimester bleeding--variables which affect the outcome of pregnancy.

A prospective study of 65 women with midtrimester bleeding was undertaken in order to assess the outcome of pregnancy and to determine variables which significantly affect it. Of the entire group, 48 (73.8%) delivered after 26 weeks of gestation (39 of them at term). The total fetal loss (abortions plus perinatal deaths) was 31.8%. Three patients who needed blood transfusions subsequently required immediate termination of pregnancy due to severe bleeding. Discriminant analysis revealed that three independent variables had a significantly unfavorable effect on the outcome of the pregnancies: a decrease in hemoglobin of more than 1 g%, duration of hospitalization (reflecting duration of bleeding) of more than 1 week and the presence of a previous uterine scar.

Abortion, Spontaneous↗
PubMed1991

Curettage vs. nonsurgical management in women with early spontaneous abortions. The effect on fertility.

Among 114 women with early spontaneous abortions, low beta-human chorionic gonadotropin levels and no ultrasonographically demonstrable residual tissue in the uterine cavity, 68 underwent uterine curettage, and 46 were managed conservatively. No complications, such as bleeding or infection, were observed in either group, and the probability of conception, outcome of subsequent pregnancies and rate of subsequent abortions were similar. Curettage offers no advantage over conservative management in selected patients with early abortions.

Abortion, Spontaneous↗
PubMed1991

Abnormal cervical cytologic, colposcopic and histologic findings in exposed DES young Israeli Jewish women.

A consistently higher rate of abnormal cervical cytology, colposcopic and histologic findings in 89 DES exposed Israeli Jewish women was found as compared to 318 women in a control group. This trend however reached statistical significance for abnormal colposcopic and histologic findings only in the 25-34 age group. The higher rate of abnormal findings can be attributed to DES exposure and not to an excess of other risk factors in the study group. Routine cytologic and colposcopic examination is recommended for DES exposed Israeli Jewish women who are otherwise at low risk for development of cervical neoplasia.

Adult↗
PubMed1991

Pelvic malignancy presenting as a pelvic inflammatory process in pre and postmenopausal women.

Among two hundred and twenty-one patients admitted with the diagnosis of pelvic inflammatory disease (PID), 6 had an underlying malignancy. The rate of underlying malignancy was 1.4% in premenopausal patients and 42.8% in postmenopausal patients. This difference was statistically significant, p less than 0.001. In postmenopausal patients presenting with a pelvic inflammatory process pelvic malignancy should be highly suspected and thorough examination made.

Adult↗
PubMed1991

Acute renal failure associated with intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection in ovarian cancer patients.

Acute renal failure associated with intraperitoneal cisplatin chemotherapy occurred in 4 courses of treatment each given to one patient, and comprised 3.4% of the total number of intraperitoneal treatment courses. The 4 patients recovered completely, 2 of them after dialysis. Several possible reasons for this complication, which occurred in spite of thiosulphate systemic protection, are considered. Strict adherence to the treatment protocol is mandatory in order to avoid severe nephrotoxicity.

Acute Kidney Injury↗
PubMed1991

Midtrimester abortion induction with intraamniotic prostaglandin F2 alpha in women with previous uterine surgery.

Of 207 women who underwent midtrimester induced abortion with intraamniotic prostaglandin F 2 alpha instillation, 30 (14.5%) had had one or more previous uterine operations. Multivariate analysis showed no correlation between a previous uterine operation and the hospitalization length, procedure complication rate or length of the injection-delivery interval (IDI). The IDI was similar in patients with and without a previous uterine operation. No case of uterine rupture occurred. Intraamniotic prostaglandin instillation for midtrimester abortion induction seems to be an effective procedure without severe complications in women with previous uterine operations.

Abortion, Induced↗
PubMed1990

Prediction of residual trophoblastic tissue in first-trimester abortions and low levels of human chorionic gonadotropin beta-subunit.

The clinical data and the histologic report of curettage specimens of 174 patients with first-trimester abortion and human chorionic gonadotropin beta-subunit less than 500 mIU/ml were reviewed. In only 22 (12.6%) were chorionic villi histologically reported. A multivariate analysis showed that increased log human chorionic gonadotropin beta-subunit levels within the range of 20 to 500 mIU/ml, intrauterine tissue demonstrated by ultrasonography, higher gestational age, and active bleeding were significant predictive variables for the presence of villi in curettage specimens. A mathematical formula and a clinical scoring system for the prediction of residual villi in these cases were devised and were applied to the data of our study group. The sensitivity, false-negative rate, and specificity of the scoring system were 90.9%, 2.2%, and 59.2%, respectively; however, the false-positive rate was 75.6%. By use of this scoring system in patients with first-trimester abortion and low human chorionic gonadotropin beta-subunit level, the presence of villi in curettage specimens can thus be predicted with a high sensitivity and as many as 60% of curettage procedures might be prevented.

Abortion, Induced↗
PubMed1990

Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries.

1. Benzodiazepines are involved in the control of proliferation and differentiation of normal and malignant cells in vitro. This regulatory ability is probably mediated via peripheral benzodiazepine-binding sites. 2. In the present study we compared the binding characteristics of peripheral benzodiazepine-binding sites in human epithelial ovarian carcinoma with those in benign ovarian tumours and normal ovaries. 3. The affinity and density of peripheral benzodiazepine-binding sites in homogenate preparations of ovarian carcinoma as compared with benign ovarian tumours and with normal tissues (used as controls) were determined using a ligand specific for peripheral benzodiazepine-binding sites, [3H]PK 11195, an isoquinoline carboxamide derivative. 4. We observed a robust (three- to five-fold) increase in the neoplasm compared with benign ovarian tumours and normal tissues, without a concomitant change in affinity values. 5. This finding may reflect a change in the metabolic rates of ovarian cancer which is expressed as the alteration in the density of peripheral benzodiazepine-binding sites.

Adenocarcinoma, Papillary↗
PubMed1990

Metastases to the endometrium from breast carcinoma.

Three patients with primary breast carcinoma and metastases to the endometrium presented with postmenopausal bleeding. All patients had locally advanced breast cancer at the time of diagnosis, and all developed other distant metastases concomitantly or shortly after the diagnosis of endometrial involvement. The treatment of breast carcinoma metastatic to the endometrium is palliative. Distinguishing metastatic carcinoma from primary endometrial carcinoma is of great practical clinical significance, since in the latter surgical intervention is indicated.

Breast Neoplasms↗
PubMed1989

Intraperitoneal cisplatin chemotherapy versus abdominopelvic irradiation in ovarian carcinoma patients after second-look laparotomy.

The current study compares the outcome within 3 years after diagnosis in two groups of histologically confirmed Stage II-IV ovarian carcinoma patients in complete clinical remission with minimal or no residual disease at second-look laparotomy, performed after completion of cisplatin-based combination chemotherapy. One group (n = 18) received after reexploration abdominopelvic irradiation (RT group), the other, diagnosed during a later period (n = 19), received three courses of intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection (IP group). The two groups were comparable with regard to age, stage at diagnosis, histologic category, grade of differentiation, size of residual tumor after the initial operation, and rate of negative second-look laparotomy. The overall survival probability after diagnosis was significantly better in the IP group, the maximal difference being observed at 36 months: 76.6% versus 44.4% in the RT group (P = 0.04). This difference was mainly evident in patients with a negative second-look laparotomy in whom the respective survival probabilities were 100% versus 70% (P = 0.04). Survival was significantly shorter (P less than 0.01) in patients with a positive second-look, and there was a nonsignificant trend for better survival in the IP group. Significantly improved probability of progression-free interval after diagnosis was also found in the IP group, the maximal difference being observed at 22 months: 78.3% as compared to 50.9% in the RT group (P = 0.04). This difference was again limited to patients with negative second-look, the respective values being 100% versus 60% (P = 0.05). Our retrospective data suggest an apparent advantage to intraperitoneal cisplatin treatment in these patients which should be further explored for definite evaluation.

Adult↗
PubMed1989

Second-look laparotomy in ovarian carcinoma patients after 8 and after 12 courses of cisplatin-based chemotherapy.

Sixteen ovarian carcinoma patients who received 12 courses and 21 patients who received 8 courses of cisplatin-based combination chemotherapy were compared. The two groups showed similar rates of second-look laparotomy (10/16 vs. 14/21) and similar rates of negative second-look laparotomies (6/10 vs. 9/14). The advantages of earlier reexploration are possibly lower toxicity and earlier recognition of patients with tumors resistant to the initial chemotherapy.

Adult↗
PubMed1989

Abdominopelvic radiation for stage I-II ovarian cancer. The effect of grade on outcome.

The initial postoperative treatment of 31 patients with stage I-II ovarian cancer of epithelial origin, consisted of abdominopelvic radiotherapy. The 5-year survival was significantly better in stage I as compared to stage II (81.1% vs 36.3%). There was a consistent trend in both stages for better outcome in grades 1-2. This trend, however, reached statistical significance only for PFI. Most of the patients with recurrent disease had grade 3 tumors. While satisfactory treatment results may be achieved with postoperative radiotherapy for stage I-II tumors which are well or moderately differentiated, it is not recommended for undifferentiated tumors.

Abdomen↗