Adriamycin and radiation: synegistic cardiotoxicity.
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Cardiomyopathies↗
Biomedical subjects
J Merrill
Publications and source records attributed to J Merrill.
Effect of calcium and parathyroidectomy on gastrin and parathyroid hormone levels in dialysis patients.
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Age Factors↗
Evaluating treatment effectiveness. Changing our expectations.
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Humans↗
Planning for new health human-power.
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Financing, Government↗
Drug inhibition and cellular regulation of prostaglandin G/H synthase isoenzyme 2.
Prostaglandin G/H synthase isoenzyme 2 (PGHS-2) was identified as an immediate-early gene product induced by Rous sarcoma virus, serum, phorbol ester and a wide variety of other mitogens. Induction of PGHS-2 occurs through an increase in PGHS-2 gene transcription. Dexamethasone inhibits both the basal and induced levels of PGHS-2 mRNA. In contrast, PGHS-1 gene transcription rate, mRNA, and protein levels are unaffected by mitogens and dexamethasone. Post-transcriptional down-regulation of PGHS-2 mRNA plays a significant role in causing dexamethasone's effect. Specific cell systems have been identified which allow selective analysis of PGHS-1 and PGHS-2 at the nucleic acid and protein levels. These cell systems indicate that PGHS-1 and PGHS-2 may have different sensitivities to non-steroidal anti-inflammatory drugs. Furthermore, inhibition of PGHS activity correlates well with suppression of the transformed phenotype in an in vitro cell model.
Animals↗