An open label, phase I/II clinical trial to evaluate the safety and biological activity of HIV-IT (V) (HIV-1IIIBenv/rev retroviral vector) in HIV-1-infected subjects.
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Biomedical subjects
Publications and source records attributed to J Merritt.
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1. Dark-eyed Juncos (Junco hyemalis) were maintained on one of three semi-synthetic diets, differing only in their sulphur amino acid content. 2. 35S-methionine was administered intraperitoneally after 3 days on their respective diets and the animals were killed 24 or 96 hr post-injection. 3. Faecal loss of 35S-methionine was significantly lower in the low methionine/high cysteine (HC) group after 24 hr when compared with other two dietary groups (4.69 vs 5.53 and 5.47%) indicating a whole-body conservation of the limiting amino acid. 4. Incorporation of 35S-methionine in hepatic and intestinal tissues was also greater in the HC group, even as the animals were losing body weight.
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Intravitreal irrigation with Balanced Salt Solution Plus (BSS Plus) produced less decrease in b-wave amplitude than either normal saline solution or Balanced Salt Solution. BSS Plus was more suitable for intravitreal irrigation because it contained the appropriate bicarbonate, pH, and ionic composition necessary for maintenance of normal retinal electrical activity, and it contained glutathione, which is necessary for maintenance of endothelial cell adenosine triphosphatase and for protection against free radical damage and oxidative stress.
Acute proliferative retrolental fibroplasia (RLF) has been studied in premature infants employing a Zeiss fundus camera and fluorescein angiography. A total of 164 angiograms have been performed on 122 infants. At the present time, angiography is reserved for studying infants with peculiar or puzzling fundus pictures. A dose of 0.1-0.4 cc of 10% sodium fluoresceinate is employed, depending on the age and the weight of the baby. Fluorescein clearly outlines the major arteriovenous shunt in the retina, which is the hallmark of acute RLF. The shunt fills with fluorescein and leaks it profusely. On regression, a fine brush border of capillaries is seen in the region where the shunt previously had been located. Study of the population susceptible to RLF reveals it to be the smallest sickest babies in the premature nursery.
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