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J Metellus

Publications and source records attributed to J Metellus.

7 recordsLinked to original sources
PubMed1990

[The aging of language].

Language does not age as long as the cerebral structures which keep it functioning are normal. But one of the vicissitudes of old age is a weakening of linguistic and intellectual abilities caused by the progressive alterations of nervous functions. Language ailment is then rarely isolated but it belongs to a global disorganizing of cerebral functions.

Aged↗
PubMedDate not supplied

[Efficacy and tolerability of cycletanine in aged patients with hypertension].

Moderate arterial hypertension of the elderly has to be treated but the efficacy has to be progressive. Cicletanine has a pharmacokinetic profile well fitted to the therapy of this age group. The mechanism of action is characterized by synthesis of prostacyclin. A double blind prospective randomized study was conducted at two institutions on 132 patients aged more than 60, with diastolic arterial pressure over 95 mmHg and systolic over 160 mmHg. 62.9% of them were aged more than 75. The analysis of those two studies shows that the three groups with cicletanine (respectively 50, 100 and 150 mg per day) had a significant decrease of both pressures versus placebo. In the 50 mg group, 40% of arterial pressures were normalized after 3 months of treatment. There were no difference between 50 and 100 mg. There were no adverse drug reaction like falling down, day or night, or orthostatic hypotension. The biological tolerance, more particularly renal, was excellent with this dose of 50 mg a day. Cicletanine at the dose of 50 mg/day is a recommended treatment in arterial hypertension of the elderly.

Aged↗
PubMedDate not supplied

[Neuroleptics and analgesia (author's transl)].

Recent studies have shown that the explanation given for the analgesic effects of neuroleptics based only upon modification of pain interpretation is not valid at the present time. Studies by K. Ramabadran, J. J. C. Jacob, Greese et al., of Leysen and Smee and Overstreet, which take into the account the secretion of endogeneous "ligands" enkephalins and endorphins, offer the possibility of a better approach for understanding the role of neuroleptics in the control of pain. We have attempted to use this interpretation to explain the regular and constant efficacy of tiapride against pain generally and particularly in headaches.

Analgesics↗