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J Methfessel

Publications and source records attributed to J Methfessel.

12 recordsLinked to original sources

Measurement of human lumbar spine ligaments during loaded and unloaded motion.

Length changes in the ligaments of human lumbar spine motion segments were investigated in order to find conditions under which unusual stress or stress reduction is found in the longitudinal ligaments and facet joint capsules. Flexibility measurements were performed under load. Increasing load and height reduction in the motion segment increases the flexibility. The anterior and posterior longitudinal ligament normally operate in the elastic part of their stress-strain curve. Destruction of the intervertebral disc leads to a dislocation of the centers of rotation in the motion segment. Two types of facet joint capsules were observed. Height reduction in the motion segment leads to abnormal strains in one type sooner than in the other, which can be normalized by slight flexion. Injection of a silicone compound into the disc normalizes many of the changes in the motion segment due to height reduction.

Humans↗

[Organ and subcellular distribution of transmidinase in man and rats].

The transamidinase capacity of human organs is consistently higher than those of rats. Both species show the highest activity in pancreas and slightly smaller in kidneys. The human liver is less active while the enzyme is not present at all in rat liver. Very low enzyme activities have been found in spleen, heart and skeleton muscle. During cell fractionation of kidney and pancreas a remarkable loss of enzyme activity occurs. Thus the transamidinase in man and rat is equally found in cytosol, mitochondria and nuclei. In the native cell the enzyme is probably localized mainly in the mitochondria.

Amidinotransferases↗

[Influence of uncoupling agents on the capacity of transamidinase in kidney and pancreas].

It was found in white rats that hyperthyreosis (0.5% thyreoidin in dry food), respectively 2,4-dinitrophenol (30 mg/kg body weight/day i. p.), deficiency of the vitamins K and E or complete fasting increase the content of creatine in muscle, plasma and urine, but reduce the concentration of creatinine. Simultaneously the elevated creatine level of blood causes a repression of transamidinase in kidneys and pancreas. The common mode of action of the mentioned agents is seen in a decoupling of the oxidative phosphorylation, and in an insufficient availability of ATP, respectively.

Adenosine Triphosphate↗

[Transamidinase].

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Amino Acids↗