PubMed Health⌕ Search

Biomedical subjects

J Mohan

Publications and source records attributed to J Mohan.

At least 37 records · Page 2Linked to original sources
PubMed1990

Effects of cyproterone acetate and testosterone treatments on some physical parameters, angiotensin converting enzyme activity and fertilizing ability of spermatozoa of domestic cocks (Gallus domesticus).

Healthy adult cocks were administered through the intramuscular route with 1 or 15 mg cyproterone acetate (CyA)/kg b. wt. or testosterone at the rate of 1.5 mg/kg b. wt. daily for a period of 25 days. High doses of CyA and testosterone caused severe suppression (P less than 0.01) of semen volume, sperm concentration, sperm motility and angiotensin converting enzyme activity (ACE EC 3.4.15.1). Fertilizing ability of spermatozoa was also reduced drastically at the end of treatment period. No loss of sexual behaviour was observed in treated birds as compared to controls. Recovery in all parameters from deleterious effects of these drugs was rapid after cessation of treatment. Lower doses of CyA did not affect the parameters of semen. The results are discussed in relation to the possible mechanism of action of CyA and testosterone.

Animals↗
PubMed1989

Studies on antifertility effects of gossypol acetic acid in domestic cocks.

Daily oral administration of gossypol acetic acid (40 mg/kg body weight daily) resulted in a gradual decrease in the semen volume and sperm concentration. Fertility dropped to zero at the end of the treatment period. Activities of acrosin, hyaluronidase and angiotensin converting enzyme were also drastically decreased by the end of the treatment period. A loss of appetite, loss of body weight and morphological abnormalities in spermatozoa were noticed in the treated cocks. At 4 weeks after cessation of the treatment, full recovery of the above measures was recorded. Healthy chicks were hatched and were observed for several months.

Acrosin↗
PubMed1986

Private medical care and the British conservative government: what price independence?

This paper discusses issues raised by the uneven expansion of private health care in Britain in recent years. The problems being experienced by the industry have exposed divisions in the private health care industry and have provoked criticisms of the Government and requests for a greater degree of state support for, and regulation of, the industry. The paper therefore examines the scope for changes of government policy to facilitate further expansion. It argues that few of the alternatives are either technically adequate, in terms of solving the private sector's problems, or politically feasible, in the sense of being electorally justifiable. It concludes that policies to further private sector expansion could be implemented only at the cost of the private sector's independence, or at the expense of the Government's commitment to the NHS.

Economic Competition↗
PubMed1985

Restructuring health care: the social geography of public and private health care under the British Conservative Government.

The 1979 election of the Conservative Government in Britain was not followed by the demolition of the welfare state. However, a variety of policy initiatives were introduced both to restructure National Health Service (NHS) expenditure, and to facilitate private provision of health services. This article considers the effects of such policies on the existing and future distribution of health care resources. A historical introduction discusses the main thrusts of conservative welfare policy. This is followed by an examination of the current financial situation of NHS authorities, at the regional and sub-regional scales; the political response to the 1983 manpower reductions is also considered. Events in the NHS are then contrasted with the deregulation of the private sector. The emergence and distribution of commercial acute hospitals are examined, as are other initiatives designed to transfer some of the financial burden of welfare provision away from the state. A concluding section compares and contrasts these developments and considers prospects for the future form of health care provision in Britain.

Catchment Area, Health↗
PubMed1983

Location--allocation models, social science and health service planning: an example from North East England.

This paper reports on a project carried out by the author to assess strategies for hospital location in the Durham Health District, England. This project was set up in the context of a dispute on hospital strategy between the relevant Regional and Area Health Authorities and so the development of the dispute is outlined. This is followed by a summary of the work carried out in which some reservations about the techniques employed are put forward. The subsequent debates between the Regional and Area Health Authorities are also discussed. The paper concludes by raising more general issues concerning the role of the state and the use of knowledge in planning.

Catchment Area, Health↗
PubMed1980

Vascular smooth muscle response to fibrinogen degradation products and 5-hydroxytryptamine: possible role in cerebral vasospasm in man.

1 Experiments were performed to determine the effects of fibrin(ogen) degradation products on the following in vitro vascular preparations: rabbit aortic strip, rat aortic strip and human basilar arterial strip. 2 Citrated plasma and streptokinase were incubated at 37 degrees C to produce a crude preparation of fibrinogen degradation products and 0.1 ml aliquots were removed at various time intervals. These samples were tested for intrinsic activity and possible interactions with EC50 and threshold concentrations of 5-hydroxytryptamine on the vascular preparations. 3 Enhancement of the responses obtained by both concentrations of 5-hydroxytryptamine was produced by samples taken throughout the streptokinase incubation period, the maximum effect being seen at 90 min. 4 The 90 min incubate produced volume-dependent (25-400 microliters) potentiations of the responses developed in the three vascular preparations to the EC50 and threshold concentrations of 5-hydroxytryptamine. 5 It is suggested that fibrin(ogen) degradation products may be involved in the intense vasoconstriction of the cerebral arteries following subarachnoid haemorrhage.

Animals↗
PubMed1977

Effects of (+) and (-)-propranolol on the responses of the human isolated basilar artery to cerebrospinal fluid obtained from patients with subarachnoid haemorrhage and cerebral arterial spasm.

1. The human isolated basilar artery has been used as a model to investigate the aetiology of cerebral arterial spasm associated with rupture of intracranial aneurysms. 2. The isolated artery is contracted by 5-hydroxytryptamine, noradrenaline, six prostaglandins and cerebrospinal fluid from patients with ruptured aneurysms and cerebral arterial spasm. 3. These contractions are reversed by (+/-)--, (+)-- and (--)-propranolol in concentrations known to produce local anaesthetic effects on isolated frog sciatic nerve; the (+) isomer was 2.5 to 10 times more potent (-)-propranolol in antagonising all contractions. 4. As the two isomers are known to have similar local anaesthetic potency but (-)-propranolol has greater beta-adrenoreceptor blocking effects we conclude that the antagonistic effects described do not involve beta-adrenoreceptor blockade. 5. The data indicate that propranolol may be of clinical use in reversing cerebral arterial spasm.

Basilar Artery↗
PubMed1976

Ribosomal DNA and its expression in Drosophila melanogaster during growth and development.

Ribosomal DNA content has been determined in several adult and larval tissues of Drosophila melanogaster. Underreplication of rRNA genes was observed in polytenic salivary glands of larvae. On the contrary, polytenic/polyploid ovaries showed no decrease in rDNA. It is concluded that polyteny is not necessarily associated with underreplication of rDNA. No other tissue examined displayed any change in rDNA redundancy. Third-instar-larvae showed a decrease in rDNA amount which might be partly accounted for by underreplication of rDNA in salivary glands. No such decrease was seen in pupae. Bobbed genotypes were essentially similar to wild type in all tissues except salivary glands. In this case, it was found that the extent of underreplication is less in bobbed as compared to wild genotypes. Ribosomal DNA activity was examined in various tissues of Drosophila melanogaster. The rates of rRNA synthesis vary greatly between various tissues. It is concluded that a control at the level of gene activity operates as differences in the amount of precursor rRNA synthesized can be observed both in flies of varying rDNA contents as well as in various tissues of the same genotype.

Animals↗