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Biomedical subjects

J Molin

Publications and source records attributed to J Molin.

15 recordsLinked to original sources
PubMed1979

Are pancreatic beta-cells under vagal control?

To elucidate the importance of cholinergic innervation for pancreatic beta-cells in vivo, atropine sulphate (0.2 mg/kg body weight) was subcutaneously injected into mice 4 times a day for 10 days. Control animals received 0.9% NaCl. Paraffin sections of the pancreas were stained for beta-cells with aldehyde fuchsin and for alpha-cells (glucagon cells) with silver according to Grimelius. Endocrine and exocrine cell nuclei were measured with an ocular screw micrometer. The light absorbance at 550 nm wave-length of aldehyde-fuchsin-stained islet sections was measured with a microscope photometer. Atropine caused no loss of body weight or apparent food consumption. The nuclei of beta-cells shrank significantly in response to atropine; A550 of islet surfaces showed a significant negative correlation to beta-cell nuclear size. Acinar cell nuclei near islets also became smaller after atropine treatment but to a lesser extent. No such change was observed in the alpha-cells. A trophic influence of the vagal nerve may be important for the long-term control of beta-cell function.

Animals↗
PubMed1978

Roentgenologic appearance of fibromuscular dysplasia.

Clinical and roentgenologic findings in 100 hypertensive patients with fibromuscular disease of the renal arteries are presented and compared with the experiences obtained from previously reported large series. Frequency of bilateral disease and abnormal findings at urography, involvement of segmental arteries and occurrence of extrarenal manifestations are reported. A striking female preponderance is noted, and there is evidence that the disease inflicts middle-aged rather than young women.

Adolescent↗