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Biomedical subjects

J Moline

Publications and source records attributed to J Moline.

At least 19 recordsLinked to original sources
PubMed1991

[Pulmonary siderosis and long-term respiratory risks of arc welders].

Pulmonary siderosis and bronchial cancer are respiratory risks in the long term in arc welders. We report a case of siderosis discovered from radiological abnormalities in a patient of 56 who had been an arc welder for 30 years. An analysis of the broncho-alveolar lavage liquid and transbronchial biopsy confirmed an iron overload and revealed patchy interstitial fibrosis. The toxic risks in arc welders arise from the gaseous fumes produced and inhaled particles at the alveolar level. The pulmonary siderosis is currently considered as a simple pneumoconiosis with a good prognosis. Some recent studies suggest the possibility of a more serious outcome with fibrosis even in the absence of any associated silicosis. The risks of bronchial cancer seem to be principally linked to exposure to chrome. A better understanding of these risks could be furnished by data from epidemiological studies which are still lacking.

Bronchoalveolar Lavage Fluid↗
PubMed1987

[Bronchial provocation tests in 59 asthmatic children. Comparison with skin tests and specific serum allergens].

Fifty nine asthmatic children were assessed by skin tests (prick-tests) (TC), specific serum IgE level (R.A.S.T.) and bronchial provocation tests (TPB) with house dust, mites, grass pollen, animal scales and moulds. The concordance of the skin and R.A.S.T. tests with the provocation test, chosen for reference and their diagnostic value was analysed using decision matrices. There was a significant connection between the results of the three tests. The concordance level was only moderate not passing 68%. By comparison to TPB there were numerous false positive Prick-tests and false negative R.A.S.T. The negative predictive value of TC was satisfactory. The most discriminatory threshold for the positive R.A.S.T. was the class 3 response. These results allow the following diagnostic possibilities to be considered. For a common allergen a negative prick-test (TC) would lead to the end of the investigations except for certain particular cases; for an allergen of low prevalence a positive TC should be taken into account, and completing this with RAST and TPB. One could envisage a reduction in the number of TPB and R.A.S.T. performed, reserving them for cases where a discordance between the clinical history and the T.C.

Adolescent↗
PubMed1978

Correlations between variations of electrical field at the body surface and contractions of the stomach in guinea pig.

1. The slow potentiel changes of the base line of the electrocardiogram recorded by cutaneous electrodes, here called EGEG (electrogastroenterogram) have been recorded simultaneously with the electromyogram and pressure variations of the stomach antrum. 2. Periodic fluctuations of EGEG, 400 microV amplitude, were correlated with activities of the antrum EMG consisting of 3 to 6 mV spikes superimposed on slow wave of depolarization, and with gastric intraluminal pressure of 5 to 7 cm of water. 3. An anticholinergic drug abolished all those activities. A gastric contracture flattened the EGEG. 4. Rhythmic distensions of the antrum induced a synchronous modulation of EGEG, the magnitude of which was correlated with the amplitude of distension. These result suggest that the origin of EGEG is essentially the movements of stomach.

Animals↗
PubMed1977

The radiospirometric flow-volume diagram recording technique and comparative study with conventional spirometry.

The spirometric flow-volume diagram recorded for a forced expiration gives information which is used in assessing obstructive or restrictive pulmonary diseases. Regional data of the same kind can be achieved using a simple radiospirometric technique and scintillation camera. A series of images during inspiration and expiration are defined and a time-activity curve with an integration time constant of about 100-200 ms is obtained from the images during the forced expiration phase. The equivalent of the flow-volume diagram, i.e., the time derivative of the activity vs. activity is computed. There were 21 subjects studied in this series. Normal subjects or patients with various diseases underwent classical spirometry, so that the global radioactive diagram could then be compared to the spirometric flow-volume diagram and its parameters expressed in terms of volumes and flow: vital capacity, peak flow, mean flow, flow at mean volume. The correlation with classical spirometry is highly significant. Similarly regional data are consistent with the pulmonary results.

Adult↗
PubMed1976

[Radio-electrogastro-enterographic correlations (author's transl)].

Recording of the electro-gastro-enterogram (E.G.E.G.) and the simultaneous taking of a 70 mm ampliphotography series shows the high degree of correlation between E.G.E.G. and peristaltis, with characteristic waves for each part of the digestive tract, both in the normal condition as well as in certain pathological states. The future and role of the E.G.E.G. appear very promising, on the one hand by virtue of its simplicity and secondly because of the information it is capable of providing from a functional viewpoint. In no case, however, can it replace the precise nature of radiological images.

Action Potentials↗
PubMed1975

[Diffuse interstitial pulmonary fibrosis. Responsibility of hard metals].

In a factory processing Tungsten carbide and hard metals, of a hundred exposed workers, 15 showed signs of "irritation" which progressed in 5 to clinical, radiological and functional pulmonary fibrosis with altered CO transport. In one patient histological sections were studied and typical findings of dust inclusion seen. Diffuse interstitial fibrosis related to heavy metals is still not yet recognised as an industrial disease in France.

Adult↗
PubMed1975

[Electrogastroenterographic study of the digestive motor effects of prolonged psychotropic treatment].

Functional digestive complaints are frequent in psychiatri patients: simple constipation, which cannot be explained solely by the loss of the sensation of rectal fullness; occlusions, occasionally hemorragies; the late complication of dolichomegacolon (Bourgeois, 1973). In 160 subjects, an attempt to understand the physio-pathology were made by recording diurnal digestive motor activity using skin electrodes placed on the abdomen and extremities (electrogastroenterography or E.G.E.G.). A hypoactive E.G.E.G. was observed in 2/3 of 18 psychotic depressive patients, in 3/4 of 36 schizophrenies. The nocive effect of giving sedative phenothiazine and antiparkinsonian drugs (trihexyphenidyl or ethybenzatropine) during long periods is clear. Whereas non sedative phenothiazine and clotiapine gicen in small doses, do not have an undesirable effect. Sulpiride has been used in gastroduodenal dyskinesia. The dyskinesia noted by the E.G.E.G., sometimes found in the large intestin, were found in 55% of 30 patients with caracter disorders; they coincide with the high frequency of electro-encephalogram dysrythmies. Finally, in hysterical patients, one usually observes normal E.G.E.G., tracings which confirms the clinical observation that hysterical and psychosomatic symptoms, may succeed each other, but do not appear at the same time. In the same categories of patients, no longer treated in a classical psychiatric environment but in a group with institutional objectives, the same clinic results were obtained with fewer digestive disturbances. This tends to show the inutility and nocivity of excessive doses of psychotropic drugs given alone or in complexe association.

Adolescent↗