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Biomedical subjects

J Moor-Jankowski

Publications and source records attributed to J Moor-Jankowski.

At least 19 recordsLinked to original sources
PubMed1989

Complexity of the Rh antigen demonstrated by comparative tests using antisera of human and primate origins.

Comparative analysis of two antisera, one produced in chimpanzee and another of human origin, demonstrates the existence of the whole spectrum of antibodies directed against at least four, and possibly five, antigenic determinants connected with the Rh reactivity. Some of the determinants are shared by chimpanzee and human red cells, while others are restricted to one species only. Based on this study, it is suggested that both the human Rh(D)-positive type and its chimpanzee counterpart, the Rc-positive type, could be of common origin, while the negative types are the results of later, parallel events during the evolution.

Animals↗
PubMed1988

Chimpanzees and AIDS research.

Pressure is mounting to relax the regulations on importation of chimpanzees for research. Such a policy is unnecessary and would deepen the plight of an already endangered species.

Acquired Immunodeficiency Syndrome↗
PubMed1983

The BP graded blood group system of the baboon: its relationship with macaque red cell antigens.

The first blood group system to be defined in baboons by means of isoimmune agglutinating reagents is composed of five graded types: B4, B3, B2, B1 and b, inherited, as postulated, by five allelic genes with decreasing dominance order. There are significant differences in distribution of the BP blood groups between hamadryas baboons on the one hand, and cynocephalus and anubis on the other, which may serve as auxiliary taxonomic criteria. Antibodies of specificities related to the BP graded antigens are found in the sera of presumably nonimmunized baboons, and also in the rhesus isoimmune antisera that detect one of the subtypes of the so-called Drh graded system of macaques. These findings point to ubiquity of the BP or BP-like antigens, and to the close serological relationship between BP baboon and Drh macaque red cell antigens, perhaps as evidence of a common ancestral antigen which gave rise to a diverging set of graded subspecificities of baboon and macaque red cells, respectively.

Animals↗
PubMed1980

Chimpanzee R-C-E-F blood group system: a counterpart of the human Rh-Hr blood groups.

A chimpanzee blood group system is defined by a set of isoimmune antisera, anti-Rc, anti-Cc, anti-Ec, anti-Fc, anti-Cc and anti-Cc1, that distinguish 19 blood types. Population analysis of 285 unrelated animals and the study of 21 chimpanzee families support the postulated model of inheritance by 9 allelic genes. There is a close relationship between the R-C-E-F blood group system and human Rh-Hr blood groups as indicated by overall structural resemblance of both systems and by serological similarity of their principal antigens, Rc and Rho. There are indications that R-like structures are also present on the red cells of other anthropoid apes, and possibly on those of the Old World monkeys.

Alleles↗
PubMed1980

Blood groups : immunogenetic markers in primate animals and their use in breeding and standardization.

The importance of immunogenetics for definition and standardization of laboratory animals has been demonstrated by their successful application for breeding of laboratory mice and rats, and in planned breeding of large domestic animals. Among the immunogenetic markers used, blood groups are the best known and generally considered as the most important. For close to two decades, serology and genetics of blood groups have been investigated by this Laboratory in the most commonly used laboratory primates, namely, macaques, (rhesus, crab-eating, pig-tailed and bonnet), baboon (olive, yellow and hamadryas) as well as chimpanzees. Blood groups of many other primate species have also been surveyed but in a less intensive manner. Blood groups of apes and monkeys are defined by standard methods of human serohematology, using both reagents developed for typing human blood and reagents obtained from the sera of immunized primate animals. The presently available reagents define, depending on species, between 10 and 25 blood groups in macaques, 20 to 25 blood groups in baboons and 45 types in chimpanzees. The available blood group genetic markers will be listed and their value for standardization and breeding of laboratory primates will be discussed.

Animals↗
PubMed1978

Blood groups of pig-tailed macaques (Macaca nemestrina).

The human-type A-B-O blood groups of 57 pig-tailed macaques (Macaca nemestrina) were determined and the calculated gene frequencies, O = 0.8908, A = 0.0825 and B = 0.0267, gave excellent fit with the hypothesis of inheritance by triple allelic genes. In tests for simian-type blood groups with rhesus, baboon and crab-eating macaque immune antisera, it was shown that the red cells of pig-tailed macaques are polymorphic for several simian-type specificities defined by those cross-reacting sera. Pig-tailed macaques share with other macaque species the complex Drh-graded blood group system, which seems to occupy a special role among red cell antigens of macaques. Normal sera of three female macaques contained spontaneous isoagglutinins which selectively agglutinated the red cells of some pig-tailed as well as stump-tailed macaques.

ABO Blood-Group System↗
PubMed1978

Rh antibodies produced by an isoimmunized chimpanzee; reciprocal relationship between chimpanzee simian-type isoimmune sera and human anti-Rho reagents.

An isoimmune chimpanzee serum was found to contain, in addition to expected antibodies of the simian-type specificity anti-Lc, a fraction of anti-Rho specificity, as proved by parallel tests with standard human anti-Rho sera as well as by absorption experiments using human and chimpanzee red cells. On the other hand, the two human anti-Rho sera tested in parallel were found to contain not only antibodies of specificity anti-Rho but also antibodies capable of detecting Lc specificity on the chimpanzee red cells. The reciprocal relationship between human and chimpanzee isoimmune sera constitutes the first example of symmetrical cross-reactivity between closely related species. The new source of anti-Rho reagents is expected to contribute additional information on the human Rh-Hr blood group system.

Animals↗