Biomedical subjects
Publications and source records attributed to J Moor-Jankowski.
Tests for spontaneously occurring agglutinins in the sera of nonhuman primates showed that such antibodies are not infrequent. Some act as heteroagglutinins, others as autoagglutinins, while of most interest are the isoagglutinins, especially those found in female animals apparently resulting from isoimmunization in pregnancy.
The simian-type blood group specificity Drh of rhesus monkeys, first described in 1967, has been proved to be the keystone of a rhesus monkey blood group system, holding a position comparable to that of Rho in the Rh-Hr system. Unlike the Rh-Hr system, however, it does not react well by the ficinated red cell technique and it includes a series of antigens giving graded reactions comparable to those of the human A1-A2 subgroups. The antigens of the Drh system appear to be the most strongly immunogenic, and are thus of greatest importance for the experimental use of these animals, such as in transplantation and blood transfusion.
Four mountain gorillas (Gorilla gorilla beringei) were tested for their human-type and simian-type blood groups. They were all found to be human-type B, MN, He, Rho and chimpanzee simian-type V.O, CeF, G, H.
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Family studies were carried out the investigate the genetics of the chimpanzee simian type blood group systems V-A-B-D and C-E-F. In addition to providing new data, the studies confirm the validity of earlier results obtained by population genetics methodology for deducing genetic mechanisms in primate animals where family material cannot be obtained.
Blood grouping of nine pygmy chimpanzees revealed them to be human-type group A1, M,Rho, and simian-type V.D, CCef, g, H, I, K, L. Only group Nc was polymorphic. Pan paniscus red cells can be easily distinguished from those of Pan troglodytes by the serological characteristics of human-type blood groups A and M. Also, the distribution of the simian-type blood group systems V-A-B and C-E-F are strikingly different in the two species.
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The current status of erythroblastosis fetalis in man and in animals is briefly reviewed with emphasis on present knowledge of nonhuman primates as models for the disease. Our studies in crab-eating macaques indicate that presence in a mother's serum of potent antibodies reactive for red cells for her fetus will not necessarily cause erythroblastosis; in one case the maternal antibodies did not penetrate the placental barrier, and in two cases although the fetal red cells were maximally antibody-coated, they remained undamaged and the disease failed to develop.
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