Biomedical subjects
Publications and source records attributed to J Morvay.
A comparative analysis of low, normal and high activity of HBDH, CK, and gamma-GT was made using different kinetic measurement principles. The data revealed that the two-step integration technique and multi-point measurements evaluated by computer are essentially more accurate than the traditionally applied 3 x 1 minute enzyme determination.
The level of protease acrosin in the seminal plasma of oligozoospermic men was significantly higher than that of normozoospermic men. The amount of bradykininase in the seminal plasma was very high in both normozoospermic and oligozoospermic patients. When the acrosin and kininase content was referred to one million spermatozoa, seminal plasma kininase was significantly enhanced in oligozoospermic men, while the acrosin activity was similar in normozoospermic fertile men and infertile men. Human seminal plasma inhibitor I (HUSI I) increased along with sperm count. Human seminal plasma inhibitor II (HUSI II) showed no change. The motility of spermatozoa was depressed in oligozoospermic patients.
Variations of the 17-beta oestradiol, progesterone, and prolactin levels in the serum were studied in the context of ten spontaneous parturitions. All cases were investigated within the first five puerperal days, but in five cases additional checks were undertaken over the first four weeks of the puerperium. Milk secretion was measured, as well. The oestradiol and progesterone titres were found to remain below the level common toward the end of pregnancy. They dropped rapidly after parturition and remained low throughout the puerperium. Prolactin underwent slight variation on parturition, but it actually stayed at the high level measurable at full term. Parturition was followed by brief temporary rise and, again, by decline, but values remained above those of non-pregnant women throughout puerperium. Milk production increased gradually over the first five days and remained similarly high throughout several weeks, accompanied by accordingly high prolactin levels. No absolute correlation was found to exist between the extent of lactation and the prolactin level. The presence of a relationship between oestradiol and progesterone levels, on the one hand, and lactation, on the other, cannot be assumed with probability.
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Ten hyperprolactinemic patients were treated by a daily dose of 5 mg bromergocryptine (Parlodel, Sandoz). The prolactine concentration in the peripherial blood showed a fast declind and after two months the patients were relieved from the symptoms (galactorrhea, amenorrhea). As side-effects of the compound headache and nausea were noted.
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The authors studied sulphadimidine crystal forms with particular reference to the occurrence of polymorphism. They were able to differentiate five crystalline forms by microscopic examination. Differential thermal analysis and IR absorption spectral methods were not reliable. The data from X-ray diffraction patterns of two crystal forms (methanol form I, ethanol form II) were reproducible by estimating their relative intensities. The crystal forms investigated were compared by in vitro and in vivo experiments. Experiments showed that sulphadimidine crystals recrystallized from ethanol had better dissolution and absorption characteristics than sulphadimidine crystals recrystallized from methanol.
Those hormone-determination methods were reported by the authors which help to make the ovary response visible for the experts during the ovulation induction. They also dealt with the determination of basal temperature measuring, oestrogen, pregnandiol, progesterone, oestradiol-17beta, FSH, LH, epimestrol and clomiphen. After the routine determination of the above mentioned parameter a preprinted sheet was done, where every treated case was illustrated graphically. From these cases some of the typical ones were shown and analyzed. The determination of hormonal releasing curves characteristic of hyperstimulation, and the importance of these most dangerous complication was emphasized.
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