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Biomedical subjects

J Mosbech

Publications and source records attributed to J Mosbech.

At least 19 recordsLinked to original sources
PubMed1992

Use of cimetidine and other peptic ulcer drugs in Denmark 1977-1990 with analysis of the risk of gastric cancer among cimetidine users.

The prevalence of use of peptic ulcer drugs in the Danish population is described at two points in time using registrations of applications for reimbursement. In 1977-81, the prevalence of use of cimetidine was 0.4% in men and 0.2% in women. In 1989-90, the prevalence of use of peptic ulcer drugs was 1.3% in men and 1.2% in women. The increase in prevalence was apparent in all age groups, but most pronounced at relatively old age. The median age of users increased from 55 years in 1977-81 to 63 years in 1989-90. The data indicated that a third of those who used peptic ulcer drugs in 1977-81 also used these drugs in 1989-90, conditional on surviving this period. The probability of becoming a long term user was highest for those who were 50-69 years in 1977-81. The incidence of gastric cancer was investigated in the cohort of persons who used cimetidine in 1977-81. An excess risk of gastric cancer was apparent in the first years after start of cimetidine use. This is thought to reflect a selection bias. Significantly increased incidence was also observed in women seven years or longer after start of cimetidine use (RR = 4.7; 95% CI: 1.7-10.3). This estimate was, however, based on only six cases, and a similar pattern was not observed in men.

Adult↗
PubMed1990

The WHO principles for registering causes of death: suggestions for improvement.

In the ongoing 10th revision of the International Classification of Diseases, the WHO's rules for registering causes of death are revised. Previous studies have shown that deficiencies in the WHO's rules and basic concepts for registering causes of death impair the quality of cause-of-death statistics. The purpose of the present paper is to elucidate some of these shortcomings and to make suggestions for improvement. Also, the purpose of the WHO's definition of 'the underlying cause of death' is discussed, and a modification suggested. Suggestions are also made for new definitions of the four basic WHO concepts, 'causes of death', 'the underlying cause of death', 'direct cause' and 'contributory conditions'. At the end an account is given of the proposals made within the WHO for changes in the rules for registering causes of death.

Cause of Death↗
PubMed1990

The pattern of cancer in a large cohort of stroke patients.

A cohort of 113,732 stroke patients from Danish Hospital Discharge Registry were, by linkage to the Danish Cancer Registry, found to have developed a total of 5151 cases of cancer in a mean follow-up time of 2.4 years after the diagnosis of stroke. There was no excess of gastric cancer. The present findings fail to support the existence of a common, strong risk factor for stroke and gastric cancer in individuals. In the cohort, more cancer than expected was observed. In particular, a more than ten-fold increase in risk of brain tumours within the first year after stroke diagnosis was observed, suggesting some diagnostic misinterpretation of a brain tumour as a stroke. Minor excesses of cancer of other sites were also found in the first year of follow-up. They are probably due to increased medical surveillance and diagnostic misinterpretation of an underlying malignancy as an incident of cerebrovascular disease, eg through metastatic spread to the brain.

Aged↗
PubMed1979

Pernicious anaemia as a risk factor in gastric cancer.

In order to assess the risk of gastric cancer (GC) developing in patients with pernicious anaemia (PA), the prevalence of PA was analysed in all patients with GC notified to the Danish Cancer Registry in 1972. Among 877 patients with GC, PA had previously been diagnosed in 19 (2.2%). In seven of these, PA had been diagnosed only shortly before GC. Accordingly, the diagnosis of PA could be regarded as unquestionable only in the remaining 12 cases (1.3%). In either case, the frequency of PA was significantly higher than in a reference group of patients with cancer of the colon who had been selected in the same way. Calculation of the incidence of GC in PA patients showed that this was about three times higher than in the general population. The annual risk of GC was calculated to be 0.3%. In PA patients, the tumour was primarily localized to the body and fundus of the stomach, whereas it mainly involved the antral and pyloric region in patients without PA. In view of the low cancer rate it is concluded that routine gastroscopy and barium meal examination are not indicated in PA patients in general. Whenever a patient with PA complains of dyspepsia, examinations with gastroscopy and barium meal should, however, be carried out on liberal indications.

Adult↗
PubMed1978

[Acute hepatitis].

Explore the source record for details and available documents.

Acute Disease↗
PubMed1978

Diet, transit time, stool weight, and colon cancer in two Scandinavian populations.

In samples of adult men from two Scandinavian populations with 4-fold differences in colon cancer incidence, a comparison was made of estimated food records over 4 days, defecation habits, mouth-to-anus transit time, and stool weight. The "high incidence" group consumed more white wheat breads and total meat and beer, but less potatoes and milk than the "low incidence" group. Defecation habits were similar. Transit time and stool weight had few significant correlations with diet and defecation habits, but stool weights were higher in the low incidence group. The results are consistent with a possible protective role of dietary fiber, unrelated to transit time.

Colonic Neoplasms↗