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Biomedical subjects

J Mosiewicz

Publications and source records attributed to J Mosiewicz.

At least 19 recordsLinked to original sources
PubMed2001

[Methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes].

Hyperhomocysteinemia is recognised as a risk factor of ischaemic heart disease and vascular complications of arterial hypertension. Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is associated with hyperhomocysteinaemia. The aim of the study was the assessment of an association of the above polymorphism with type 2 diabetes with special attention to myocardial infarction and arterial hypertension accompanying diabetes. The study group consisted of 172 type 2 diabetics. 172 control subjects with normal glucose tolerance were age and sex matched to patients with diabetes. C677T polymorphism in MTHFR gene locus was detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. CT and TT genotypes were found more often among diabetics (OR 1.83, 95% CI 1.16-2.89; p < 0.01). This finding may be secondary to the excess of T allele bearers among diabetics with myocardial infarction when compared to diabetics without infarction and to control group. Upon obtained results the potential role of genotypes CT and TT as risk factors of myocardial infarction among patients with type 2 diabetes could not be excluded (OR 2.33, 95% CI 0.93-5.8; p = 0.07). Genotypes containing T allele are not associated with diabetes type 2 and concomitant arterial hypertension (OR 1.45, 95% CI 0.89-2.57; p = 0.14). A confirmation in further studies is needed for the presented findings.

Aged↗
PubMed2001

The influence of glucose-insulin-kalium mixture (GIK) on the selected parameters of acid-base balance in acute myocardial infarction.

The aim of the paper was assessing the influence of polarizing GIK mixture on the selected indicators of acid-base equilibrium in patients with acute myocardial infarction treated fibrinolytically. The patients had arterial blood taken in order to check pH, partial pressure of oxygen and carbon dioxide, and the content of bicarbonates. Changes in the examined parameters in the group obtaining GIK and in the one obtaining placebo were subject to critical analysis. Changes in gasometric parameters taking place under the influence of GIK administered to patients were also analysed according to the site of infarction. It was observed that after 24 hours from the beginning of infusion pH increased and pCO2 decreased in comparison to the initial examination. These changes did not depend on the kind of applied infusion (GIK or physiological saline infusion), no significant changes in bicarbonates being observed. However, after applying GIK infusion, an increase in oxygen pressure in comparison with the control group was observed, and differences between the groups were within the boundaries of significance. Neither was there observed any influence of infarction site on changes in the assessed parameters of acid-base equilibrium in the group treated with GIK nor in the one receiving placebo.

Acid-Base Equilibrium↗
PubMed2001

HRCT examinations in the course of silicosis.

Evaluation of diagnostic possibilities of high definition computerized tomography was performed on the material of 38 patients with recognized silicosis of small opacities on the bases of long lasting exposition, clinical and radiographic picture. Special usefulness of HRCT was shown in revealing early, scanty, radiographically imperceptible nodular changes. The presence of the so-called air traps was shown on expiratory sections.

Female↗
PubMed2001

Cardiopulmonary manifestations of subarachnoid hemorrhage--a case report.

The study presents a case of a 48-year-old female patient, in whom first symptoms of subarachnoid hemorrhage were suggestive of acute pulmonary oedema, caused by acute left ventricular insufficiency, evoked by myocardial infarction. The authors discuss the course of illness, diagnostic difficulties and changes in circulatory system, which can appear as a result of subarachnoid hemorrhage.

Cardiovascular Diseases↗
PubMed1999

[Bronchial hyperreactivity as a factors of chronic obstructive pulmonary disease development in the population of the Bogdanka coal miners].

The aim of the study was to assess the role of bronchial hyperreactivity in the development of chronic airflow obstruction in the population of the Bogdanka (Lublin Basin) coal miners. The population examined consisted of 1456 coal miners working underground in the Bogdanka colliery. The methods of the study included plethysmographic measurements of total airway resistance (Raw), spirometric measurements of forced expiratory volume in one second (FEV1), and determination of forced expiratory flowa at 75, 50 and 25 per cent of vital capacity (FEF75, FEF50 and FEF25%VC). The measurements were repeated twice--before and after administration of 0.2% solution of methacholine (1 min inhalation). Pulmonary function tests were also performed 8 years after initial measurements. The increase in the Raw value above 0.6 kPa/l/s was observed in 5.5% of the population examined. In this group of subjects the skin prick tests with common allergens, measurements of total immunoglobulin E (IgE) levels and determination of blood eosinophils count were performed. Only 12% of all hyperreactives (Raw increase > 0.6 kPa/l/s) showed features of atopy--positive skin prick tests, raised IgE levels, and increase in blood eosinophils count. Using a survival analysis as a statistical tool we evaluated for how long the pulmonary function tests remained within normal ranges in two groups: hyperreactives and controls. All hyperreactives (atopic and non-atopic) showed significantly higher risk of lung function decrease below the normal values as compared with the control group.

Adult↗
PubMed1999

[M235T polymorphism of human angiotensinogen gene in essential hypertension in Polish population].

Genetic factors play very important role in the pathogenesis of essential hypertension. Angiotensinogen gene is one of the candidate genes in the research concerning genetic background of elevated blood pressure. The aim of this work was to assess an association of M235T polymorphism in human angiotensinogen gene with essential hypertension in Polish population. 250 patients with essential hypertension and 150 normotensives were involved in the study. M235T polymorphism was detected using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Polymorphic allele and genotypes frequencies did not differ between hypertensive and normotensive groups. However T allele and TT genotype frequency among hypertensive men was higher than in normotensive men. The difference is statistically significant. T allele and TT genotype occurred more frequently in hypertensives with positive family history of essential hypertension. The difference between hypertensive men with positive family history and normotensive men was even more significant. This results are similar to those already published by other authors concerning Caucasian populations and indicate that angiotensinogen gene is involved in the determination of at least some cases of essential hypertension.

Alleles↗
PubMed1998

Right ventricular function in systemic hypertension.

The aim of the study was the assessment of right ventricular (RV) structure and diastolic function in hypertensive subjects. The study group consisted of 44 patients with untreated, mild to moderate essential systemic hypertension. All the patients were in sinus rhythm, no symptoms of congestive heart failure, ischaemic or valvular heart disease and lung disorders were found. Twenty-six healthy subjects were the control group. M-mode echocardiographic measurements of the right ventricular wall (RVW) diastolic thickness, right ventricular outflow tract diameter (RVOTD), left ventricular (LV) structure and LV systolic function were performed. Pulsed Doppler echocardiography was used to measure peak early (TE) and peak atrial (TA) right ventricular diastolic filling velocities as well as velocity-time integrals (VTI-TE and VTI-TA). TE:TA and VTI-TE:VTI-TA ratios were calculated. Similar parameters of the left ventricular diastolic filling were recorded at the level of mitral annulus. Mean pulmonary artery pressure (MPAP) was measured non-invasively by the estimation of pulmonary artery systolic flows. We demonstrated in hypertensive patients significantly thicker RVW (3.94 vs 2.8 mm, P < 0.001) and increased LV mass. In the hypertensive, increased TA and VTI-TA and diminished TE:TA and VTI-TE:VTI-TA ratios were recorded, indicating the abnormalities of RV diastolic function. RV diastolic filling parameters correlated positively with corresponding parameters of LV filling. The results of our study demonstrate that impairment of LV diastolic function, the common finding in systemic hypertension, is associated with diastolic disturbances of the right ventricle. RVW thickening and hypertrophy of interventricular septum seem to be major factors influencing RV diastolic function.

Adult↗
PubMed1996

[Echocardiographic evaluation of pulmonary artery flow parameters in patients with chronic pulmonary disease].

This study aimed at comparing the Doppler echocardiographic artery blood flow parameters in patients with and without chronic obstructive pulmonary disease (COPD), and estimating an effect of the present degree of airway obstruction on systolic functioning of the right ventricle. The study included 28 patients with COPD, and 22 patients without COPD constituting a control group. Pulmonary functional tests have been performed with the use of body plethysmography. Doppler echocardiographic assessment of the pulmonary artery flow included a measurements the acceleration time (AcT), and right ventricular ejection time (RVET). Both AcT and RVET have been corrected for the heart rate. Corrected AcT shorter than 100 ms has been considered specific for the pulmonary hypertension (PH). AcT in the studied group of patients ranged from 67 ms to 143 ms (mean 106 +/- 21), and has been significantly shorter than that in the control group. However, no correlation between body plethysmographic findings and echocardiographic measurements has been found in COPD patients. Echocardiography is a sensitive technique detecting PH. As spirometric findings do not predict development of the cor pulmonale, Doppler echocardiographic evaluation of the blood flow in pulmonary artery may serve as a screening test.

Adult↗
PubMed1993

[Effect of smoking cigarets, age and underground working time on lung function in the Bogdanka (lublin Basin) coal miner population].

The purpose of the present study was to examine simultaneous effects of age, smoking and dust exposure on pulmonary functional parameters in coal miners population, working underground in the Bogdanka colliery. The study population consisted of 1456 coal miners. Total airway resistance and intrathoracic gas volume were measured by body plethysmography. Spirometric and flow volume parameters were also determined. The results of the measurements were expressed in per cent of normal values. Our results reveal that simultaneous effects of the three factors examined had an influence on almost all the measured parameters. Smoking as a single factor influenced ITGV, TLC and, in borderline, FEF 25% FVC. Underground working time formed solely Raw, ITGV, RV and TLC. Age as a sole factor had an impact on many parameters (ITGV, RV, FEV1, FVC, PEF). The additional effect of smoking and underground working time makes this influence much more significant. Smoking and occupational exposure to dust generally lead to additive changes towards bronchitis--related airflow limitation in the population under study. The expiratory flow decrease and intrathoracic gas volume increase seem to be sensitive parameters to detect early effects due to the influence of smoking and dust exposure.

Adult↗
PubMed1992

[Reference values of selected parameters of lung functions in the population of Bogdanka coal miners].

The aim of the study was to construct and test new equations for calculating FEV1, ITGV and FVC predictive values. Our examined population consisted of 2058 coal miners working underground in Bogdanka colliery (Lublin Basin). The following persons were excluded from out considerations: 1. smokers, 2. miners with pulmonary or allergic diseases history, 3. patients with chronic cough, sputum production or symptoms of chronic rhinitis, 4. persons with bronchial hyperreactivity. Finally, our standard group consisted of 353 coal miners. On the basis of our standard group data, new equations for calculating predictive values were formulated using the multiple regression model. According to these new equations and to equations elaborated by other authors, we calculated predictive values for FEV1, FVC and ITGV in our standard population and expressed results of measurements in percentages of different predictive values. Our predictive values in the standard population were significantly higher than the other authors' values. Percentages of predicted values were lower in the same comparison. We believe that observed differences are linked to a possible self-selection phenomenon in occupationally exposed population, relatively small maximum age of our standard group, possible differences in anthropometric features among examined populations and excluding hyperreactives. Our results seem to emphasize the need of greater attention to the paid on more restrictive use of the specially formulated equations in separate age compartments.

Adult↗
PubMed1992

[Unfavorable blood lipid indicators in obesity].

There were evaluated total serum cholesterol, cholesterol HDL, cholesterol LDL and triglycerides in relation to relative body weight, calculated according to Broca-Broughs formula and changes in body weight during last 5 years in 306 males aged 40-59 from the housing estate "Czechow" in Lublin. Mean total cholesterol, cholesterol LDL and triglycerides concentration were higher and cholesterol HDL was lower in overweight males in comparison with normal weight subjects. Significantly higher mean triglycerides concentration was stated in becoming overweight as compared with stable weight males.

Adult↗
PubMed1990

[Risk factors of coronary artery disease in males during a 3 year follow up based on a cohort study in a selected region of Lublin].

To assess changes in risk factors of coronary artery disease, examinations which had been performed in 1981 and 1982 were repeated in males aged 40-59, inhabitants of the district "Czechów" in Lublin. The study was based on Polish Experiment of Coronary Disease Multifactor Prevention assumptions 112 of 203 males investigated in 1981, 1982 underwent repeated examination (attendance rate - 55%). Statistical analysis was performed only in twice examined subjects. Significant increase of blood pressure, body weight, total serum cholesterol and uric acid concentration was stated in comparison with their respective initial values. Significant decrease of HDL-cholesterol and no changes in serum triglycerides concentration were observed. The only positive stated alteration was a lower percentage of tobacco smokers. Diagnosis of coronary artery disease remained unchanged despite of increased risk factors levels (increase of mean Rose's index score from 5 in initial examination to 6.5 in a control one). This high increase in risk factors occurrence allows an unfavourable prognosis for future incidence of coronary artery disease and also demands to undertake vigorous prevention.

Adult↗
PubMedDate not supplied

Polymorphisms of angiotensin-converting enzyme and angiotensin II receptor type 1 genes in essential hypertension in a Polish population.

BACKGROUND: The angiotensin-converting enzyme gene and the angiotensin II type 1 receptor gene meet the criteria for candidate genes in the pathogenesis of essential hypertension. The aim of this study was to assess the possible association between polymorphisms of these genes and essential hypertension in a Polish population, to evaluate them as possible genetic markers of susceptibility to hypertension, and to search for interaction between the two polymorphisms. MATERIAL AND METHODS: The insertion/deletion polymorphism at the angiotensin-converting enzyme gene locus and the A1166C polymorphism at the angiotensin II type 1 receptor gene locus were detected using the polymerase chain reaction and restriction fragment length methods. 250 patients with stable essential hypertension lasting at least 1 year were compared to 150 individuals without signs and symptoms of cardiovascular disease or family history of hypertension. RESULTS: No association was found between the insertion/deletion polymorphism at the angiotensin-converting enzyme locus and essential hypertension in the study population, although the DD genotype occurred more often (p<0.01) among patients with hypertension and a negative family history of hypertension than among hypertensives with a positive family history. There was an association in our study population between hypertension and the A1166C polymorphism at the angiotensinogen II type 1 receptor gene locus. The frequency of occurrence of the C1166 variant was higher among patients with hypertension (0.29) than in control subjects (0.20). The CC genotype occurred more frequently among hypertensives (0.10) than in the control group (0.04). Both these differences were statistically significant. This association was stronger in males, patients with a negative family history of hypertension, and non-obese patients with a body mass index less than 26 kg/m2. To test the interaction between the polymorphisms in question, the distribution of the A1166 and C1166 variants among ACE genotypes was assessed. The A1166 variant occurs more often among DD genotype normotensives. CONCLUSIONS: There was no association in our study population between essential hypertension and the I/D polymorphism at the angiotensin-converting enzyme gene locus. The C1166 variant of the angiotensin II type 1 receptor gene was associated with hypertension in our study population, while the A1166 variant seems to be protective as regards susceptibility to hypertension.

Alleles↗