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Biomedical subjects

J Mott

Publications and source records attributed to J Mott.

43 records · Page 3Linked to original sources

Mitomycin antibiotics. Synthesis of 7-methoxy-1-(N-pyrrolidino)mitosene and its methiodide.

7-Methoxy-1-(N-pyrrolidino)mitosene and its methiodide were synthesized. The latter compound was a potential bifunctional alkylating agent because of its two good leaving groups appropriately situated with respect to the indoloquinone chromophore. However, it was inactive in bacteriophage induction and P388 murine leukemia assays. Both compounds showed antibacterial activity in culture, and the former compound was very weakly active in inducing lysogenic bacteriophage.

Animals↗

Heroin misuse and delinquency in a new town.

The subjects of this study were eighty misusers of heroin who lived in the New Town of Crawley, West Sussex. The relationship between their criminal histories and their histories of drug misuse were examined. It was found that more of the heroin misusers than would be expected had been convicted of criminal offenses before they began to misuse drugs, while the reduction or cessation of heroin use during a four-year follow-up period was accompanied by a reduction in convictions. Some social characteristics of the male heroin misusers were compared with those of two other Crawley groups--a group of juvenile offenders who did not misuse heroin and their control group of non-delinquents. Characteristics commonly associated with maladjustment did not distinguish the heroin misusers from the juvenile offenders, nor were they found to be associated with the continued use of heroin. Analysis of the data in epidemiological terms suggested that among the necessary conditions for an outbreak of drug misuse in a particular community the availability of drugs together with socializing drug users were more important than the presence of predisposed individuals.

Adolescent↗

The criminal histories of male non-medical opiate users in the United Kingdom.

Although there is general agreement that there is some association between non-medical opiate use and criminality the nature, extent and significance of the association remains controversial. The most plausible explanation for an association is that crime becomes an economic necessity for the opiate user where there is, as in most countries, a legislative prohibition on licit supplies of the drugs. In the United Kingdom, however, opiate users may be prescribed the drugs and may also qualify for social security benefits. The criminal histories of three series of United Kingdom male non-medical opiate users are described. A somewhat higher proportion of the series had criminal convictions before any admitted drug misuse when compared with that expected from a general population sample. When age and the number of convictions before identification as opiate users were taken into account, there was no consistent evidence that they were more likely than expected to be convicted of further offences during the two-year period following identification. When the proportion found to have been convicted during this period was greater than expectation, it was due to the proportion convicted exclusively of drug offences. The criminal histories showed a decrease in the number of convictions for theft and other offences and an increase in the number of convictions for, and the number of users convicted of, drug offences during the stages of the drug using history, most particularly during the two years following identification as opiate users. The majority of the drug offences during this period involved opiates when most of the users were, or had been, in receipt of prescriptions for these drugs. It was concluded that the pattern of criminality of male non-medical opiate users was related both to the type of national drug control legislation and to their individual criminal histories.

Adolescent↗

The epidemiology of self-reported drug misuse in the United Kingdom.

Self-report methods are, in general, the only feasible way of obtaining information of the prevalence of drug misuse, other than opiate misuse, in the population. The present review examines the results of surveys of self-reported drug misuse conducted in the United Kingdom between 1968 and 1972 and discusses the findings in terms of the uses of epidemiology. The evidence from the surveys suggests that by 1972, a higher proportion of students in higher education, particularly those following courses in the social sciences, admitted to having ever misused controlled drugs compared with the general population of similar age. There were considerable local and regional variations in the prevalence of self-reported misuse. The majority of those who admitted to having ever misused drugs in the samples surveyed since 1970 said they had misused cannabis. The only individual characteristics that were found to be consistently associated with admitting to having ever misused drugs were favourable attitudes to drugs and slightly elevated neuroticism scores.

Adolescent↗

Death of a baby.

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Adult↗