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Biomedical subjects

J Mracek

Publications and source records attributed to J Mracek.

11 recordsLinked to original sources
PubMed2003

[Carotid microendarterectomy].

Atherosclerosis of the internal carotid artery with resulting stenosis, threatens the patients by cerebral ischaemia. Patients with high-grade stenosis, who have a high risk of stroke, gain profit from the surgery. The surgeon's decision is based on the clinical picture and on the degree of stenosis. The degree of the stenosis indicated for surgery was determined by international multicentric randomized studies and such indication represents the evidence-based medicine. Carotid microendarterectomy is performed at neurosurgical departments. The microsurgical technique enables perfect endarterectomy, eliminates patching and reduces risk of embolisation and vessel dissection. Cerebral ischaemia is a complex problem and carotid microendarterectomy is a part of the complex management of stroke.

Carotid Artery Diseases↗
PubMed1984

Monoclonal cryoglobulins and pyroglobulins.

In a series of 1182 monoclonal Ig, the authors demonstrated 10 cases with monoclonal cryoglobulin (0.8%) and 5 cases with pyroglobulin (0.42%) in the serum; in two of these cases both thermoproteins were present simultaneously. One observation revealed mixed cryoglobulin consisting of monoclonal IgM-kappa and polyclonal IgG. In 70 Waldenström's macroglobulinemias, monoclonal cryoglobulin occurred in 10%, pyroglobulin in 5.71%. In a subgroup of 744 monoclonal IgG, monoclonal cryoglobulin was demonstrated in 3 cases (0.4%), pyroglobulin in one case (0.13%).

Adult↗
PubMed1978

Subclasses IgG1--IgG4 in 84 sera with IgG paraprotein.

The distribution of subclasses IgG1-4 was determined in 84 sera with IgG paraprotein. The results were as follows: IgG1--58.3%, IgG2--25%, IgG3--11.9%, IgG4--4.8%. After division into the group of IgG myelomas (n = 47) and the group of non-myeloma IgG paraproteinemias (n = 37), the following distribution was found: IgG1--55.3%, IgG2--25.5%, IgG3--12.7%, IgG4--6.5% and IgG1--62.1%, IgG2--24.3%, IgG3--10.8%, IgG4--2.7%, respectively. The distribution of light chains in the individual subclasses of IgG paraproteins was also studied. In three double IgG and IgA myeloma paraproteinemias, subclass 1 IgG paraprotein was always demonstrated.

Adult↗
PubMed1978

Immunochemical and clinical characteristic of series of 516 paraproteinemic patients.

A series of 516 cases of paraproteinemia was analysed. According to the class of paraprotein, there were 336 cases of paraprotein IgG (65.1%), 101 paraprotein IgA (19.6%), 53 paraprotein IgM (10.3%) and 1 case of paraprotein IgD (0.2%); only light chains were found in 15 cases (2.9%) and doubled paraproteins in 10 cases (1.9%). The average age of the series was 64.2 years. Clinically, there were 315 cases of myeloma, 24 cases of Waldenström's macroglobulinemia, 126 cases of facultative paraproteinemia accompanying another disease, 16 cases of paraproteinemia in healthy persons and in 10 cases of paraproteinemia no precise diagnosis was made.

Adolescent↗
PubMedDate not supplied

A soluble fumarate reductase in Trypanosoma brucei procyclic trypomastigotes.

The enzyme NADH-fumarate reductase associated with the membrane fraction of Trypanosoma brucei procyclic trypomastigotes, can be solubilized by more than 50% when increasing the ionic strength to the equivalent of 150 mM KCl. The apparent KMs for NADH (125 microM) and fumarate (50 microM) remain close to those previously reported for the membrane-bound form of this enzyme. Other electron acceptors (i.e. oxygen or cytochrome c) appear to accept electrons in the absence of fumarate (KM for cytochrome c = 50 microM). The drug L-092,201 (Merck, Sharp and Dohme Research Laboratories, Rahway, NJ), an inhibitor of the membrane-bound fumarate reductase, also blocked the solubilized enzyme. Given the relatively high ionic strength of the intracellular environment we propose that, in vivo, the enzyme fumarate reductase is in the mitochondrial matrix or in the soluble fraction of another intracellular compartment.

Animals↗