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Biomedical subjects

J Mrinák

Publications and source records attributed to J Mrinák.

At least 19 recordsLinked to original sources
PubMed1982

Non-invasive methods for detection of cardiomyopathy in the course of antineoplastic treatment.

In our group of patients suffering from cancer and treated by polychemotherapy and monitored in a complex non-invasive way we obtained data as follows: A normal physical, sensoric and biochemical cardiac finding prior to treatment has been observed in 47 patients out of 68 (69.1%). A pathological cardiac finding prior to treatment has been found in 18 patients out of 68 (26.5%). Pathological changes evidencing for cardiomyopathy (CMP) induced by chemotherapy have been detected in 19 patients out of 68 (27.6%). Out of 18 patients with a pathological report prior to treatment in 8 of them the polycardiographic, echocardiographic, and biochemical alterations deteriorated during the chemotherapy. CMP induced by polychemotherapy has been found altogether in 27 patients out of 68 (39.6%). In this group of patients with clinically and biochemically detected CMP due to antineoplastic treatment, we found a significant decrease of ejection fraction (EF) (values less than 50%) and a marked increase Weisler's index (WI) (values greater than 0.520) approximately in 30% of patients. Our preliminary results show that polycardiographic examinations of systolic time interval (STI), the EF detected echocardiographically, as well as determination of myocardial isoenzyme creatine phosphokinase (CK-MB) activity represent useful non-invasive methods of early detection of any myocardial damage in the course of actinochemotherapy. A systematic monitoring of patients reduces the uncertainty with antitumor chemotherapy so that it enables--in a majority of cases--to bring the planned antineoplastic treatment to a successful end.

Antineoplastic Agents↗
PubMed1981

Functional capacity of suprarenal cortex in patients on long-term dialysis.

The authors have repeatedly examined the functional capacity of suprarenal cortex in patients on long-term dialysis by means of ACTH stimulation test. Out of 148 examinations, normal reaction was found in 111 cases, partially insufficient in 16 cases, and fully insufficient in 21 cases. Primary suprarenal insufficiency is considered for the reason of insufficient production of cortisol which develops due to enforced changes of regulatory mechanism in glucocorticoids production as a reaction on repeated long-term losses of cortisol through semipermeable membrane. According to the authors, the mentioned facts are of great significance since they may result in changes which influence the survival of patients on long-term dialysis in a negative way.

11-Hydroxycorticosteroids↗
PubMed1977

[Development of collateral circulation in the Paget-Schroetter syndrome].

An eleven years' clinical treatment of a 28-year-old tractor-driver with Paget-Schroetter's syndrome is described. The development of the collateral circulation was pursued during 6 years or 11 years, respectively, after the occurence of the vein thrombosis and the importance of phlebography in this rare disease is emphasized for the judgment of the prognosis. Phlebographic procedure is recommended for the reliable evaluation of the pathomorphological changes of the veins and of the developed collateral circulation.

Adult↗