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Biomedical subjects

J Munk

Publications and source records attributed to J Munk.

At least 19 recordsLinked to original sources
PubMed1988

Glottic carcinomas stage 0 and I. Treatment results in 151 patients.

A series of 151 patients with stage 0 and I glottic carcinomas treated during the period of 1965-1983 at the Radium Centre and the ENT-Department in Odense was analysed. The 5-year survival--corrected for intercurrent deaths--was 99%, with only 2 deaths from laryngeal cancer being observed so far. Nineteen patients developed recurrences which were treated with 11 partial and 7 total laryngectomies, while one patient received palliative treatment only. So far, 3 patients have developed new cancers inside the irradiated volume. These results are compared with the results of laser surgery. The risk of radiation induced development of new cancers is commented. The conclusion is that, so far, there is no need for a change of therapy in centres where radiotherapy is well established. However, the risk of late new cancers must be carefully observed.

Female↗
PubMed1987

Hyperfrequency of pulmonary cancer in a population of 415 patients treated for laryngeal cancer.

Four hundred fifteen patients with laryngeal cancer were treated mainly by primary irradiation from 1965 to 1983, at the Radium Centre of Odense. By December 31, 1983, a total of 32 patients had developed pulmonary cancer. The Danish Cancer Registry calculated the expected number of pulmonary cancer in a population of the same composition from the same period of time and the same geographical locale. A statistically significant hyperfrequency of pulmonary cancer among males was found, most pronounced among supraglottic cases: 6.73. Furthermore, a cumulative estimation of the risk of developing pulmonary cancer as a function of follow-up revealed a risk of 26% during the first 14 years of follow-up. The only effective way to solve the problem is to stop smoking.

Denmark↗
PubMed1984

Carcinoma of the larynx. Series of 410 patients treated primarily with 60Co irradiation.

From 1965 to 1983 410 patients were treated for laryngeal carcinoma at the radium centre and the ENT department in Odense. No change in pattern of disease could be traced during the period of 18 years. The treatment was predominantly 60Co irradiation with salvage surgery. 1977 to 1979 bleomycin, methotrexate and vincristine were given before irradiation. In 1979 split course radiation therapy was introduced in the treatment of stage II, III and IV cases and the patients were randomized, half of them receiving the radiosensitizer misonidazole, half of them placebo. Between 75 and 80 per cent of the patients were cured. Whereas chemotherapy did not change the survival some improvements may be traced in the period after 1979.

Adolescent↗