PubMed Health⌕ Search

Biomedical subjects

J Murube

Publications and source records attributed to J Murube.

9 recordsLinked to original sources
PubMed1997

Horner syndrome as an isolated manifestation of an intrapetrous internal carotid artery dissection.

PURPOSE: To describe the atypical localization and unusual clinical manifestation of an internal carotid artery dissection. METHODS: We examined a 43-year-old woman who had sudden onset of left ptosis and miosis with vague dysesthesia around her eye. RESULTS: Her examination showed an intrapetrous carotid artery dissection. CONCLUSIONS: The intrapetrous segment is an extremely rare localization for an internal carotid artery dissection. The differential diagnosis of acute Horner syndrome should include carotid dissection, which is usually accompanied by other neurologic manifestations.

Adult↗
PubMed1995

Ophthalmological tests in patients with keratoconjunctivitis sicca with and without association of primary Sjögren's syndrome.

We compared clinical, laboratory and histological tests in patients with keratoconjuctivities sicca with and without association of primary Sjögren's syndrome. Rosa bengal staining, osmolarity and impression cytology had high specificity and sensitivity for a correct diagnosis of keratoconjunctivitis sicca with and without primary Sjögren's syndrome. Schirmer and breakup time (BUT) tests were not quite as specific or sensitive. Impression cytology was the only ocular test that showed significant differences between the two pathological groups.

Adult↗
PubMed1994

Amylase in mare lacrimale in patients with submandibular salivary gland transplantation to the lacrimal basin.

Six patients with dry eyes of different etiologies underwent transplants of 1.0 to 1.6 ml of submandibular salivary gland tissue, five of them to one eye and one to both eyes. In the four cases in which the transplants survived, the amylase activity in tear fluid sampled from the cisterna lacrimalis (temporal canthal meniscus) had a mean value of 5,147 U/l in contrast with the mean value 943 U/l of the fellow control eyes. In the two eyes in which the transplants failed to survive, the average value was 635 U/l. The small sample size does not enable calculation of statistical significance to the results but suggests that salivary amylase determinations in tear fluid would facilitate assessment of the functional status of the transplanted salivary tissue.

Aged↗
PubMed1994

Previous ocular compression increases intraocular penetration of systemic drugs.

Intraocular drug penetration is dependent upon the physical and chemical characteristics of the drug, the manner of drug administration and the drug's ability to pass through the blood/aqueous barrier. Most systemically administered drugs do not achieve intraocular therapeutic levels. The authors present a new method to increase the intraocular concentration of intravenously administered drugs based on the premise that ocular hypotony by ocular compression produces a temporary break in the blood/aqueous barrier during the period of hypersecretion that follows to regain normal intraocular pressure levels. Vancomycin introduced parenterally was used as the drug model. The right eye of 22 rabbits served as experimental eye, while the left eye served as control. The concentrations of vancomycin in the aqueous humor half an hour after intravenous injection of 40 mg/kg vancomycin in 50 ml of lactated Ringer's solution were as follows: 30.17 +/- 20.68 micrograms/ml in the right (hypotonized) eyes and 4.92 +/- 3.33 micrograms/ml in the left (control) eyes. The difference in drug levels between the two sets of eyes had a high statistical significance at p = 0.001.

Animals↗
PubMedDate not supplied

Treatment of dry eye by blocking the lacrimal canaliculi.

Occlusion of the lacrimal canaliculi improves the objective signs and subjective symptoms of dry eye. In this review, methods of occlusion are classified as surgical, thermal and tamponade. Surgical methods include dacryocystectomy, canalicular ligature, canalicular offset, canalicular excision, transfer of the punctum to dry dock, punctal tarsorrhaphy and punctal patch. Thermal methods include cautery, diathermy and laser burn. Tamponade methods use absorbable inserts of hydroxypropyl cellulose, gelatin, collagen and catgut, and nonabsorbable inserts of silicone (punctum plugs, canalicular plugs), polyethylene, cyanoacrylate, and others. The characteristics of all these methods are analyzed.

Electrocoagulation↗