Biomedical subjects

J N Domingue

Publications and source records attributed to J N Domingue.

3 recordsLinked to original sources

PubMed1980

Results of surgery in 114 patients with prolactin-secreting pituitary adenomas.

The clinical features and prolactin levels of 114 patients, including five men, who had prolactin-secreting adenomas are presented. The rates of resolution of amenorrhea and galactorrhea following surgery were calculated. Fifteen women became pregnant following surgery. Therapeutic failure tended to occur in patients who had higher preoperative serum prolactin levels and those in whom total tumor resection was not achieved. Although clinical anomographic changes preceded elevation of prolactin values in two cases and, in one case, clinical indications and an elevated prolactin value preceded tomographic changes. The morbidity encountered with the procedure was minimal and there were no deaths.

Adenoma↗

PubMed1978

Coexisting pituitary adenomas and partially empty sellas.

seventeen cases of coexisting secreting pituitary adenomas and partially empty sellas are presented. The location of the cisternal invagination into the sella was not helpful in predicting the location of the tumor. In patients with endocrine indication of a secreting pituitary neoplasm, the finding of a partially empty sella should not contradict the diagnosis.

Adenoma↗

PubMed1977

Pituitary abscesses. Report of seven cases and review of the literature.

Seven cases of pituitary abscess are presented and the relevant world literature is reviewed. An enlarged sella co-existing with bacterial meningitis, or bacterial meningitis coinciding with a known or suspected pituitary tumor should suggest the diagnosis of pituitary abscess. Visual field defects should evoke similar suspicion when present in a patient with meningitis. This reasoning enabled us to make the first reported preoperative diagnosis of pituitary abscess. Therefore, in the management of purulent meningitis, we recommend the following: first, skull films are mandatory; second if the sella turcica is abnormal, the correct presumptive diagnosis is pituitary abscess; and third, if prompt improvement does not follow appropriate antibiotic therapy, the suspected abscess should be explored and drained via the transsphenoidal approach.

Abscess↗