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J N Drummond

Publications and source records attributed to J N Drummond.

7 recordsLinked to original sources
PubMed1995

Structure-activity studies of sulfate transfer: the hydrolysis and aminolysis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS).

The pH-rate profile for the hydrolysis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) in aqueous solution has been measured. Comparison with other data suggests that hydrolysis occurs by almost complete unimolecular elimination of sulfur trioxide, with weak involvement of a molecule of water in the transition state. The catalytic power (kcat/kuncat) of the sulfotransferases is estimated to be in the order of 10(10)-10(12). Amines--exemplified by morpholine--react spontaneously with PAPS in water at 39 degrees C by attack at both sulfuryl and (5')phosphoryl groups in a ratio of 2:3. The mechanism of activation of the coenzyme, PAPS, by the sulfotransferases that catalyse N-sulfation must involve suppression of its native N-phosphorylating reactivity and specific enhancement of its N-sulfating reactivity. Studies of the aminolysis of the coenzyme in aprotic solvent-water mixtures suggest how this might be accomplished.

Amines↗
PubMed1987

The effect of fatigue on the performance of a simulated anesthetic monitoring task.

In a simulated monitoring situation, 21 anesthesia residents were tested for their ability to detect significant changes in four critical variables in the presence of a concurrent distraction. Each resident was tested after a night without clinical responsibility (rested) and after 24 hours of in-house call (fatigued). When fatigued, the residents scored significantly worse on the vigilance test than when rested (57.2 +/- 15.4 versus 65.9 +/- 10.9, P less than 0.02). Despite the small population size, the possibility of subject and investigator bias, and the artificial setting, these results support the intuitive proposition that a fatigued person is less likely than a rested person to detect important changes in monitored variables.

Adult↗
PubMed1987

Bilateral fixation of a nasotracheal tube by transfacial Kirschner wires.

Because of the high margin for error with transfacial internal wire fixation, even in the hands of an experienced practitioner, alternative modalities in the treatment of zygomaticomaxillary complex fractures should be considered. When the use of transfacial rigid wire fixation is indicated, emphasis should be placed on prevention and early recognition of nasotracheal transfixation to avoid unnecessary postoperative catastrophies.

Adult↗
PubMedDate not supplied

Pulse oximetry monitoring of sedated pediatric dental patients.

Hypoxemia is recognized as a major complication of sedating pediatric dental patients. Traditional methods of patient monitoring show changes only with moderate to severe hypoxemia. This study compared pulse oximetry, a new monitoring technology, to traditional techniques in their ability to detect hypoxemia in sedated children. The results demonstrated that pulse oximetry is a more sensitive monitor of mild to moderate hypoxemia than measurements of heart rate, blood pressure, respiratory rate, or visual observation for cyanosis in sedated pediatric dental patients.

Anesthesia, Dental↗