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Biomedical subjects

J N Insall

Publications and source records attributed to J N Insall.

At least 19 recordsLinked to original sources

Knee arthroplasty rating.

A number of rating systems used to evaluate the results of total knee arthroplasty exist. Many of these systems are based on different concepts, and might be expected to give divergent results. To see if this was so, the authors examined a consecutive series of 235 posterior stabilized knee arthroplasties recording the results according to five rating systems: HSS (The Hospital for Special Surgery), Brigham, Freeman, BOA (British Orthopaedic Association), and the VENN diagram. In spite of their apparent differences, all point systems and the BOA gave almost identical results, while the VENN diagram proved to be the most stringent. The authors suggest that any of the current point systems may be used to "score" arthroplasties, but the results should also be rated with the VENN diagram in order to see the quality of the arthroplasty and a comparison between the different series.

Aged

Total knee arthroplasty in elderly patients. Comparison of tibial component designs.

The authors examined 98 total knee arthroplasties in 73 patients who were 80 years of age or older at the time of surgery (average, 82 years; range, 80-90 years). The follow-up period averaged 4.5 years (range, 2-12 years). The patients were divided into two groups based on their tibial component design. There were 38 all-polyethylene tibial components in 28 patients and 60 metal-backed tibial components in 45 patients. There were 61 (62%) excellent, 30 (31%) good, 2 (2%) fair, and 5 (5%) poor results. Three of the five poor results required revision for septic failure. Of the knees with an all-polyethylene tibial component, 20 (53%) were rated as excellent, 15 (39%) as good, and 3 (8%) as poor. One of these knees rated as poor required revision for septic failure. The knees with a metal-backed tibial tray had 41 (68%) rated as excellent, 15 (25%) as good, 2 (3%) as fair, and 2 (3%) as poor. Both of the knees with poor results required revision for septic failure. Stratifying the results by component composition revealed 97% survival for both types of tibial trays. These results were obtained at 12 years for the all-polyethylene components and at 8 years for the metal-backed prosthesis. In conclusion, the authors believe that total knee arthroplasty is a reliable and durable procedure in the treatment of knee arthritis in the elderly. Elderly patients may represent a special case because they are generally less active than younger patients and may place less stress on their prosthesis.(ABSTRACT TRUNCATED AT 250 WORDS)

Actuarial Analysis

Surgical management of gonarthrosis in patients with poliomyelitis.

The authors reviewed nine cases of degenerative disease of the knee in patients with a history of poliomyelitis. All patients were treated with a cemented total knee arthroplasty. The average follow-up period was 6.8 years (range, 6 months to 13 years), and the average follow-up knee score using the Hospital for Special Surgery rating scale was 70. Three of the patients required revision total knee arthroplasty to a more constrained implant. Pain relief was predictably very good and knee stability was initially improved. However, many of the patients suffered a decline in ambulatory ability with time.

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The significance of calf thrombi after total knee arthroplasty.

We reviewed the records of 1257 patients having 1625 total knee arthroplasties; all had pre-operative and postoperative perfusion lung scans and postoperative venograms which were classified as showing no thrombi, calf thrombi or proximal thrombi. Patients with calf thrombi were found to have a significantly greater risk for both symptomatic and asymptomatic pulmonary embolism compared with patients with no venographic thrombi. There were positive lung scans in 6.9% of patients with calf thrombi compared with 2.0% of patients with negative venograms (p < 0.001). Symptomatic pulmonary embolism occurred in 1.6% of patients with calf thrombi compared with 0.2% of patients with negative venograms (p = 0.034). The risk of pulmonary embolism was not significantly different between patients with treated proximal thrombi, and those with calf thrombi. Patients who develop deep-vein thrombosis despite prophylaxis are at increased risk for pulmonary embolism; these patients should receive treatment, or undergo follow-up studies to detect proximal propagation.

Aspirin

Historical perspectives of chondromalacia patellae.

Widespread misuse of the term chondromalacia has led to confusion regarding its true meaning. This term should not be used to diagnose patellofemoral pain, but to describe lesions of articular cartilage. Recent advances using stereophotogrammetry to evaluate the patellofemoral joint and its articular cartilage may lead to new insight into the etiology of these lesions.

Cartilage Diseases

Posterior stabilized prosthesis. Results after follow-up of nine to twelve years.

We reviewed, nine to twelve years postoperatively, the records on an original cohort of 289 arthroplasties (218 patients) in which a posterior stabilized knee prosthesis with an all-polyethylene tibial component had been inserted at The Hospital for Special Surgery. One hundred and eighty intact prostheses in 139 patients were available for this analysis. Fourteen knees in fourteen patients had had a revision procedure. Five of these fourteen patients had had a bilateral arthroplasty, but only one knee of each of the five patients had been revised. Forty-eight of the patients (sixty-six knees) had died less than nine years after the operation. Twenty-nine other knees (twenty-two patients) had been lost to follow-up before a nine-year evaluation could be performed. Considering all 194 knees (including the fourteen that had been revised), the result with the system of The Hospital for Special Surgery was excellent for 117 knees (61 per cent), good for fifty-one (26 per cent), fair for twelve (6 per cent), and poor for the fourteen knees (7 per cent) that had been revised. The 180 knees in which the prosthesis was intact were also rated with the new scoring system of The Knee Society: the average postoperative knee score was 92 points (range, 35 to 100 points), and the average score for function was 66 points (range, 0 to 100 points). Survivorship analysis showed that the average annual rate of failure was 0.4 per cent and that the over-all rate of success at thirteen years was 94 per cent.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent

Total knee arthroplasty. Current clinical perspectives.

Cemented total knee arthroplasty (TKA) has evolved to be the gold standard to which other means of fixation should be compared. Though controversy still exists regarding retention or sacrifice of the posterior cruciate ligament, clinical experience and survivorship analysis supports the use of the posterior stabilized prosthesis. Improvements in implant design, surgical technique, bone preparation, and cement technique have made TKA a more predictable procedure. With these advances, infection presently appears to be the main cause of failure in cemented TKA.

Cementation

Bilateral total knee arthroplasty. One cruciate retaining and one cruciate substituting.

Thirty bilateral-paired cruciate-retaining and cruciate-substituting total knee arthroplasties (TKAs) were evaluated two to five years after surgery. In general, the more deformed knees received the cruciate-substituting prosthesis. Preoperative Hospital for Special Surgery knee scores averaged 56.4 (range, 44-68) in the cruciate-retaining knees and 53.3 (range, 29-69) in the cruciate-substituting knees. Postoperatively, 25 patients were observed climbing stairs. All patients were scored and asked their preference of knees. Fifteen patients handled stairs normally. Five patients climbed stairs favoring the cruciate-substituting knee and four the cruciate-retaining knee. One patient favored one knee ascending and the other descending. In the cruciate-substituting knees, there were 27 excellent and three good knee scores. There were 28 excellent and two good knee scores in the cruciate-retaining knees. Ten patients preferred the cruciate-retaining knee, eight preferred the cruciate-substituting knee, and 12 had no preference. In this group of patients no clinical advantage of one type of TKA over the other was observed.

Aged

Total knee arthroplasty in valgus knees.

One hundred thirty-four total knee arthroplasties in 98 patients with a valgus alignment were analyzed. Knees with a preoperative alignment of 10 degrees or greater anatomic valgus were believed suitable for inclusion. The average follow-up period in these patients was 4.5 years (range, two to ten years). One hundred eighteen knees were implanted with a posterior stabilized prosthesis, eight knees with a constrained implant design, four knees with a total condylar prosthesis, and four knees with a cruciate-retaining design. All components in all knees were cemented. A lateral retinacular release was necessary in 76% of the arthroplasties secondary to intraoperative lateral subluxation of the patella. The ligamentous release for balancing these valgus-deformed knees was done from the femur. There were 95 knees (71%) rated as excellent, 27 knees (20%) as good, eight knees (6%) as fair, and four knees (3%) as poor. Postoperatively, 76% of the knees had a tibiofemoral alignment between 5 degrees and 9 degrees valgus with an overall average of 7 degrees valgus (range, 3 degrees varus to 15 degrees valgus). Total knee arthroplasty is a reliable and durable procedure in the treatment of valgus knee arthritis. However, valgus-deformed knees represent a greater challenge than their varus counterparts to the implant surgeon in terms of the intraoperative balancing required. This may be a function of the greater difficulty in achieving ligamentous equilibrium and the relative rarity of valgus-deformed knees.

Adult

Revision total knee arthroplasty for failed unicompartmental replacement.

The results in nineteen patients (twenty-one knees) who had a failed unicompartmental knee replacement followed by a revision total knee arthroplasty were evaluated. There were twelve excellent, four good, one fair, and two poor results. The interval between the unicompartmental replacement and the revision total knee arthroplasty ranged from eight months to eight years. At the time of the revision, a major osseous defect was found in sixteen knees (76 per cent). The duration of follow-up after the revision ranged from two to ten years. At the most recent follow-up examination, radiographs revealed at least one radiolucent line in thirteen knees (62 per cent). The technical difficulties associated with the revision operation are evidence that unicondylar arthroplasty is not a conservative procedure that allows a total knee arthroplasty to be done easily later. The results also do not support the argument that a revision performed after failure of a unicondylar arthroplasty is less technically demanding than one performed after a failed primary total knee arthroplasty.

Aged

Effects of epidural anesthesia on the incidence of deep-vein thrombosis after total knee arthroplasty.

Epidural anesthesia has been reported to reduce the prevalence of deep-vein thrombosis after total hip arthroplasty compared with the prevalence after general anesthesia. However, the effect of epidural anesthesia on the rate of thrombosis after total knee arthroplasty has not been reported previously, to our knowledge. A review was conducted of 705 total knee arthroplasties (541 patients) that had been performed by a single surgeon between September 1984 and December 1988. During this period, the operative technique, the protocol for rehabilitation, and the regimen for prophylaxis against thromboembolism did not change meaningfully. The patients received either epidural or general anesthesia. Preoperative and postoperative perfusion scans of the lungs and a venogram of the lower limb or limbs that had been operated on were done for all patients. For the 227 patients who had received epidural anesthesia, the over-all rate of deep-vein thrombosis was 48 per cent, which was significantly lower than the 64 per cent incidence in the 264 patients who had received general anesthesia (p less than 0.0001). The greatest reduction was in the occurrence of proximal thrombosis, which was identified in 9 per cent of the patients who had had general anesthesia but in only 4 per cent of those who had had epidural anesthesia (p less than 0.05). The use of epidural anesthesia reduced the incidence of proximal thrombosis after both unilateral and one-stage bilateral arthroplasty.

Adult

Knee surgery.

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Humans

Radionuclide imaging of asymptomatic versus symptomatic total knee arthroplasties.

Ninety-eight total knee prostheses were evaluated by roentgenograms and bone scans. Fifty-three were asymptomatic, and 45 were symptomatic. Thirteen prostheses required revision surgery. At a mean of 54 months, asymptomatic knee replacements generally showed only mild uptake in one or more zones. Only one knee had uptake equal to surrounding bone. However, symptomatic knee replacements showed significantly greater uptake in the patella, femur, and medial and lateral tibial plateau regions (Mann-Whitney two-sample rank test). Bone scans in the symptomatic group were obtained at a mean of 44 months. Excluding those patients who had revision surgery, the differences remained significant. Furthermore, symptomatic knee replacements with normal roentgenograms also had significantly greater uptake. Radiolucent lines were noted in 30% of asymptomatic patients, whereas 29% of symptomatic knees had radiolucencies. Radiolucencies were not generally associated with significantly greater uptake. Lateral release had no effect on the patellar score.

Adult

Cemented total knee arthroplasty for gonarthrosis in patients 55 years old or younger.

The results of 68 cemented total knee arthroplasties (TKAs) in 50 patients with gonarthrosis who were 55 years old or younger at the time of surgery were reviewed. These patients were operated on between 1979 and 1987 and were followed for an average of 6.2 years. The average age of the patients was 50 years. Patients were evaluated by the Hospital for Special Surgery knee score. The average preoperative score was 53, and the average follow-up score was 90. Overall, 55 TKAs were rated as excellent and 13 as good. Using the knee rating score advocated by the Knee Society, the average postoperative score was 92 for pain and 84 for function. There were four successful reoperations for patellar component loosening, all in metal-backed patellae. The femoral and tibial components in these patients were intact, and at the follow-up period, two knees were rated as excellent and two as good. Detailed roentgenographic evaluation demonstrated that 20% of tibial components had radiolucencies in at least one zone on the anteroposterior roentgenogram and in 11% on the lateral roentgenogram. Femoral radiolucencies occurred in only 2% of knees. Patellar radiolucencies in one or more zones occurred in 20% of knees that had not had patellar revision. No complete or progressive radiolucencies at the bone-cement interface were noted for any component, and no components were considered to be roentgenographically loose. Cemented TKAs can achieve excellent long-term results in patients younger than 55 years old with gonarthrosis of the knee. These results compare with those obtained in published reports on older age groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

Total knee arthroplasty in diabetes mellitus.

A retrospective study was done of 59 total knee arthroplasties (TKAs) in 40 patients diagnosed with diabetes mellitus. The overall infection rate was 7%, with an overall revision rate of 10% and an average follow-up period of 4.3 years. Wound complications were present in 12% of the TKAs. The rate of deep joint infections in diabetic patients was statistically higher than the reported incidence of sepsis in nondiabetic patients. Therefore, maximum precautions should be taken for diabetic patients having TKA to minimize both wound complications and joint sepsis.

Aged

Total knee arthroplasty in obese patients.

We examined 182 patients (257 knees) who had had a total knee arthroplasty two to five six years earlier. The patients were grouped into five weight classes. Eighteen patients (twenty-seven knees) were considered moderately obese and twelve patients (twenty-seven knees), severely obese. The results in all but four knees were rated excellent or good. One patient needed a revision procedure for late infection, and the result was rated poor. Three results were rated fair. There was no discernible difference in the over-all scores among the five weight groups. However, 30 per cent of the knees of the moderately and severely obese patients had patellofemoral symptoms, whereas the incidence was 14 per cent in the other groups (p less than 0.03). No clear-cut association was found between obesity and either thrombophlebitis or complications related to the wound.

Adult

Bone-block iliotibial band reconstruction for anterior cruciate insufficiency. Follow-up note and minimum five-year follow-up period.

Sixty-two of 71 patients (87%) who received a bone-block iliotibial band transfer were followed with a minimum follow-up period of five years (range, 5-10 years). Sixteen of the originally studied knees were examined with an average follow-up period of 104 months (range, 90-120 months). A second group of 46 knees was studied at an average follow-up period of 75 months (range, 60-92 months). Preoperatively, all patients had giving way (buckling). The average postoperative score of the original group was 83 (range, 52-99 points). There were nine excellent, three good, and four poor results. The average postoperative score of the second group was 89 (range, 73-99 points). There were 24 excellent, 18 good, and four fair results. Giving way was absent in 93% of the patients postoperatively; 88% had a negative pivot-shift test. Sixty-eight percent of the patients no longer used a brace for sports, 24% wore a brace for protection only, and 8% used it for instability. Improvement of at least one grade in the Lachman and anterior drawer tests was found in 61% and 85% of the patients, respectively. Pain was the major reason for fair and poor results. All but one had previous meniscectomy. There were no fair or poor results with menisci intact. So far, there has been no deterioration with time. The procedure remains ideal for recreational athletes who cannot afford a long absence from work and for those patients whose daily activities are compromised by recurrent knee instability.

Activities of Daily Living

Two-stage reimplantation for the salvage of total knee arthroplasty complicated by infection. Further follow-up and refinement of indications.

Thirty-eight total knee replacements (in thirty-five patients) that were complicated by infection were treated with a two-stage protocol for reimplantation. The clinical results in these knees (nine of which have been previously reported on) were evaluated at an average follow-up of four years (range, 2.5 to ten years). There was only one documented recurrence of infection with the original organism. Three patients in whom the immunological system was suppressed had a subsequent hematogenous infection with a different organism. According to the knee-rating system of The Hospital for Special Surgery, there were eleven excellent, thirteen good, six fair, and seven poor results. For one patient who had severe polyarticular rheumatoid arthritis, the result could not be rated. The results of this study suggested that the two-stage protocol for reimplantation, with a six-week interval of intravenous antibiotic therapy, is the procedure of choice for the treatment of an infection around a total knee arthroplasty. A patient who has polyarticular rheumatoid arthritis and in whom the immunological system is suppressed may not be an ideal candidate for the protocol. Gram-negative bacterial infection may be treated with this protocol, provided the organism is sensitive to relatively non-toxic antibiotic medication.

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