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Biomedical subjects

J N Katchaki

Publications and source records attributed to J N Katchaki.

At least 19 recordsLinked to original sources
PubMed1989

[2 men with active syphilis infection and HIV-I infection].

We report the case histories of two men who were living together and who were seropositive for human immune deficiency virus (HIV) and also had positive syphilis tests. Conceivably, reactivation of an earlier syphilis infection (which had been treated) had occurred after infection with HIV. It is therefore recommended to treat such patients according to the standard of treatment of neurosyphilis.

Acquired Immunodeficiency Syndrome↗
PubMed1980

Detection and significance of anti-HBc in the blood bank; preliminary results of a controlled prospective study.

It has been suggested that post-transfusion hepatitis B (PTHB) may occur after transfusion with blood negative for hepatitis B surface antigen (HBsAg) but positive for antibody against hepatitis B core antigen (anti-HBc). We are currently conducting a controlled prospective study of recipients of such blood to investigate this possibility. Blood donors were routinely screened for HBsAg by radioimmunoassay (RIA) and those found negative were tested for anti-HBc by RIA. The HBsAg negative, anti-HBc positive donors were then tested by antibody directed against HBsAg by RIA, antibody directed against hepatitis B 'e' antigen by enzyme-immunoassay and for the liver enzymes SGOT and SGPT. To date,, follow-up has been completed in the recipients of 141 anti-HBc positive blood donors and in a control group of the recipients of 141 anti-HBc negative blood donors. All the recipients were bled repeatedly with intervals of 4--5 weeks up to 7 months post-transfusion. Currently, no clear-cut seroconversion was observed in recipients of either group for any of the antibody markers of HBV infection. While none of the 141 recipients of anti-HBc negative blood became positive for HBsAg, 3/141 recipients of anti-HBc positive blood acquired HBsAg and developed clinically manifest post-transfusion hepatitis B.

Adolescent↗
PubMed1979

Hepatitis B core antibody in volunteer blood donors: comparison of radioimmunoassay and indirect immunofluorescence.

The results of a pilot study on the prevalence of anti-HBc in HBsAg negative volunteer blood donors are presented. Two techniques for anti-HBc determination were compared--radioimmunoassay (RIA) and indirect immunofluorescence (IF). In a panel of 56 sera with known HBV markers, RIA was found to be significantly more sensitive than IF, and both techniques were specific. Out of 2,000 HBsAg negative blood donor sera tested by RIA, 46 (2.3%) were found positive for anti-HBc. In 24/24 sera, the specificity of the anti-HBc was confirmed. Also 37/46 (80.4%) anti-HBc positives were found positive for anti-HBs, leaving 9/2,000 (0.4%) blood donors positive only for anti-HBc. It is concluded that it would be premature to advocate the introduction of anti-HBc as a routine screening test of blood donors.

Antibodies, Viral↗
PubMed1979

The occurrence of antibody markers of hepatitis B virus infection in an HBsAg-negative blood donor population.

Anti HBs, anti-HBc and anti-HBe were tested in blood donors negative for HBsAg by radio- and enzyme-immunoassay. In this population 6.4% of the donors were positive for at least one type of antibody to HBV: 4.0% for anti-HBs, 2.3% for anti-HBc and 4.3% for anti-HBe. Two sera (0.2%) were exclusively positive for anti-HBc, eight sera (2.2%) were weakly positive only for anti-HBe. Further studies of the infectivity of such samples might be of interest.

Antibodies, Viral↗
PubMed1978

Serological evidence of presence of HBsAg undetectable by conventional radioimmunoassay in anti-HBc positive blood donors.

Sera from two blood donors, one of whom was implicated in a case of post-transfusion hepatitis B, were found to be positive for anti-HBc and negative for HBsAg by conventional radioimmunoassay and were retested for HBsAg after concentration (pepsin digestion and polyethylene glycol precipitation). The presence of occult HBsAg was confirmed in both. These observations have implications for blood transfusion, and wider studies of anti-HBc in blood donors are recommended before the introduction of routine screening for anti-HBc and exclusion of the positive donors from blood donation.

Adult↗