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J N MILLER

Publications and source records attributed to J N MILLER.

At least 19 recordsLinked to original sources
PubMed1965

IMMUNITY IN EXPERIMENTAL SYPHILIS. 3. ATTENUATION OF VIRULENT TREPONEMA PALLIDIUM BY GAMMA-IRRADIATION.

Miller, James N. (University of California School of Medicine, Los Angeles). Immunity in experimental syphilis. III. Attenuation of virulent Treponema pallidum by gamma-irradiation. J. Bacteriol. 90:297-301. 1965.-Virulent, freshly isolated cells of Treponema pallidum strain Nichols suspended in a 50% rabbit serum-saline solution and exposed to a gamma-irradiation dosage of 652,800 r were rendered noninfectious without apparent loss of motility or change in observable morphological and staining characteristics. Although 5 x 10(7) gamma-irradiated organisms failed to elicit an immobilizing antibody response in rabbits, the same organisms retained their capacity to react with classical T. pallidum-immobilizing antibody.

Animals↗
PubMed1965

SEROLOGIC DIAGNOSIS OF SYPHILIS; USE OF THE TREPONEMA PALLIDUM IMMOBILIZATION (TPI) TEST AND THE FLUORESCENT TREPONEMAL ANTIBODY (FTA) TEST.

Comparative data from four different laboratories on the TPI and FTA tests on VDRL-reactive sera from patients with no symptoms of syphilis showed agreement of results of the FTA test with those obtained with the TPI test (the reference test) varying from 71 per cent to 112 per cent. The FTA test is complex and requires additional research before its use as a routine public health laboratory procedure can be recommended. The TPI test appears to be unequivocally the test of choice for the diagnosis of late and latent syphilis.

Fluorescent Antibody Technique↗
PubMed1965

TESTS FOR SYPHILIS. THE INCREASING INCIDENCE OF BIOLOGIC FALSE POSITIVE REACTIONS AS MEASURED BY TREPONEMA PALLIDUM IMMOBILIZATION.

Analysis of data obtained in 25,787 Treponema pallidum immobilization tests in a ten-year period showed an increase in the incidence of biologic false positive (BFP) reactions for syphilis, and a decrease in the incidence of reactive TPI tests. The percentage of BFP tests increased from 54.2 per cent in 1953 to 70.7 per cent in 1962. Reaction to a standard serologic test for syphilis (STS) indicates only that the patient may have syphilis. A subsequent non-reactive TPI test remains the best procedure for ruling out a diagnosis of syphilis. Thus the clinician should be made more aware of the fact that a biologic false positive reaction strongly implies the existence of another disease, the cause of which should be investigated.

Biological Products↗
PubMed1963

CORONERS' DUTIES.

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Coroners and Medical Examiners↗