Biomedical subjects
J N MacPherson
Publications and source records attributed to J N MacPherson.
Insulin for the non-insulin dependent.
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The distribution of blood flow to the whole skeleton in dogs, rabbits and rats measured with microspheres.
The distribution of blood flow to the skeleton was studied by injecting radioactive microspheres into the hearts of anaesthetised adult animals and measuring activity in individual bones and groups of bones. The mean proportion of the cardiac output delivered to the whole skeleton was 7.5% in dogs, 4.2% in rabbits and 4.5% in rats. The results throw doubt on the value for rats of 27% published by Brookes. There was a wide range of flow per unit mass of bone in different parts of the skeleton, demonstrating the inaccuracy of predicting total skeletal flow from measurements on a single bone. The relative distribution to different parts of the skeleton was similar in the three species, but there were quantitative differences.
Plasma cyclic-AMP response to parathyroid hormone in Turner's syndrome and Albright's hereditary osteodystrophy.
Purified bovine parathyroid hormone (BPTH) given by injection to five patients with Turner's syndrome, and seven healthy volunteers produced a significant rise in plasma cyclic AMP reacing a maximum within 10 min. In a pseudohypoparathyroid patient there was no increase. Urinary excretion of cyclic AMP exceeded the normal in three out of four patients with Turner's syndrome. Thus, if there is a relationship between Turner's syndrome and Albright's osteodystrophy it is with the incomplete form known as pseudo-pseudohypoparathyroidism.
Bone blood flow and age in the rat.
1. The proportion of the cardiac output delivered to the skeleton and individual bones has been determined in rats of differing ages and weights with radioactive microspheres. 2. There was a decrease in the blood flow to the tibia--fibula, jaw, femur, pelvis, humerus, radius and ulna, and scapula with increase in age and weight of rats, but no change was seen in blood flow to the ribs, spine, skull or whole skeleton. 3. The proportion of the cardiac output delivered to the whole skeleton was approximately 3%. 4. The derived values for skeletal blood flow agree well with estimates by other authors using the technique of bone uptake and blood clearance of 45Ca.
Activation analysis by 252californium for the estimation of the calcium content of bone.
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The relationship between thyroid function and the renal response to parathyroid hormone.
The effect of thyroid status on renal adenosine 3', 5'-cyclic monophosphate (cyclic AMP) metabolism was assessed by measuring the increase in plasma cyclic AMP concentration following the intravenous administration of parathyroid hormone (PTH) to five hypothyroid and six hyperthyroid patients and seven euthyroid control subjects. PTH caused a rapid, transient increase in the concentration of plasma cyclic AMP which was similar in magnitude and time course in the euthyroid and hyperthyroid groups, but reduced in magnitude in the hypothyroid patients. The magnitude of the plasma cyclic AMP response to PTH was positively related to the free thyroxine index. The results suggest that the development of hypothyroidism may impair the renal response to PTH by affecting the turnover of cyclic AMP in the renal cortex.
A note on bacteriocine typing techniques.
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