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Biomedical subjects

J N Pande

Publications and source records attributed to J N Pande.

At least 19 recordsLinked to original sources
PubMed1992

Pulmonary function and immunologic abnormalities in miliary tuberculosis.

In a group of 33 patients with miliary tuberculosis (MTB), pulmonary function testing and bronchoalveolar lavage (BAL) were each performed in 31. The arterial blood gas analysis was done in 13 patients. Mild restrictive ventilatory defect, hypoxemia, and hypocapnia were observed. BAL revealed lymphocytic alveolitis. The lymphocyte subsets were measured in the BAL fluid and peripheral blood in 10 patients. The helper lymphocytes were decreased in the peripheral blood and increased in the BAL fluid. The immunoglobulins (IgG, IgA, and IgM) were significantly increased in the peripheral blood and BAL fluid in 18 patients. Serum complement (C3) (n = 23) and BAL fluid fibronectin (n = 22) were also significantly increased. Lymphocytic alveolitis and the raised levels of IgG and IgA in the peripheral blood and BAL fluid persisted at the end of 9 months of standard chemotherapy for tuberculosis. Long-term studies with larger numbers of patients are required to monitor the course of alveolitis in MTB. An addition of corticosteroids to the antituberculosis drug regimen may be considered in the treatment of these patients.

Adult↗
PubMed1991

Effect of prednisolone treatment in chronic silicosis.

We evaluated the effects of daily oral prednisolone therapy on alveolitis parameters and pulmonary function tests over a 6-month period in patients with chronic silicosis. Pulmonary function tests were done in 34 patients, and bronchoalveolar lavage (BAL) was done in 21 of them. Pulmonary function tests showed a significant improvement in lung volumes, FEV1, PEFR, SGaw, DLCO, and PaO2. Analysis of BAL fluid revealed a significant decrease in total cell count. Mean fibronectin and immunoglobulin values in BAL fluid also were lower after treatment, but the change was not statistically significant. No serious side effects were encountered with prednisolone therapy. These results indicate that daily oral prednisolone therapy may suppress the alveolitis in certain patients with chronic silicosis and bring about a significant improvement in lung functions and gas exchange.

Adult↗
PubMed1990

Effect of verapamil inhalation on bronchial asthma.

The effect of inhaled verapamil 20 mg on pulmonary functions and arterial blood gases in 15 patients with extrinsic bronchial asthma was studied in single-blind fashion. A significant decrease (p less than 0.05) in airway resistance and a significant increase (p less than 0.01) in specific conductance was observed after verapamil inhalation. A small increase (p less than 0.1) was observed in forced vital capacity and peak expiratory flow rate after verapamil inhalation; however, this was not statistically significant. None of the parameters of pulmonary function tests showed a significant change after normal saline inhalation. A significant fall in PaO2 (p less than 0.05) and PaCO2 (p less than 0.05) was noted after normal saline inhalation. PaCO2 showed a significant fall (p less than 0.01) after verapamil inhalation. Alveolar arterial oxygen gradient P(A-a)O2 widened significantly (p less than 0.001) after normal saline inhalation. A larger dose (20 mg) of verapamil inhalation produces a significant bronchodilator effect on large airways, but does not produce a significant change in arterial oxygen tension from the baseline value in patients with bronchial asthma.

Administration, Inhalation↗
PubMed1990

Effect of 4% lidocaine inhalation in bronchial asthma.

The effect of 4% lidocaine inhalation was studied in a single-blind fashion in 18 patients with chronic stable asthma. Inhalation of normal saline solution was used as placebo. None of the parameters except flow rate at 50% of vital capacity (V50) showed any statistically significant change from baseline values. V50 at 15 min was significantly lower (p less than 0.05) after 4% lidocaine inhalation. Considering more than 10% change from the baseline value as significant, 8 of 15 patients showed decrease in airway resistance (Raw) and 7 of the 15 patients showed an increase in specific airway conductance (SGaw) after 15 min of inhalation. However, V50 (8/18 patients), flow rate at 25% vital capacity [V25 (6/15 patients], and forced expiratory flow rate at 25-75% of the vital capacity (FEF25-75) (5/15 patients) showed a decrease after 15 min of 4% lidocaine inhalation. No change in pulmonary function was noted after 30 min of lidocaine inhalation. It is concluded from this study that lidocaine produces a small bronchodilatory effect on the large airways and a bronchoconstrictor effect on the small airways after 15 min of inhalation, but this effect is not statistically significant. It can be safely used as topical agent for bronchoscopy in patients with bronchial asthma.

Administration, Inhalation↗
PubMed1990

Clinical and laboratory profile of systemic sclerosis in northern India.

The clinical and laboratory features of 87 patients with systemic sclerosis (SSc) are described. A large majority of patients presented with diffuse disease with extensive ulcerations and digital resorption. No case of CREST syndrome was seen. The pattern of systemic involvement was generally similar to that reported in the Western literature. Renal involvement appeared to be less aggressive and chronic in its course. A possible aetiology was identified in three patients.

Adolescent↗
PubMed1990

Value of enumerating cellular constituents of bronchoalveolar lavage fluid in differentiating sarcoidosis and cryptogenic fibrosing alveolitis.

Based on the observations of cellular constituents in the BAL fluid in 73 patients with sarcoidosis and 18 patients with cryptogenic fibrosing alveolitis, various diagnostic criteria for differentiating these two disorders were examined. Receiver operator characteristics curve was constructed using different levels of lymphocyte percent (L) in the BAL fluid. Discriminant accuracy was improved if the percent of polymorphs (P) was also taken into account. A log transformation of the ratio L/P + 1 was normally distributed and most useful in differentiating sarcoidosis from cryptogenic fibrosing alveolitis. A formal analysis of results may be helpful in assigning likelihood ratios for the observations on cellular constituents of BAL in patients suspected to have sarcoidosis.

Adult↗
PubMed1988

Bronchoalveolar lavage (BAL) in miliary tuberculosis.

We report bronchoalveolar lavage (BAL) cellular analysis in eight patients with miliary tuberculosis. The total cell count and lymphocytes count of BAL fluid were significantly increased and the alveolar macrophage count was significantly decreased in patient with miliary tuberculosis compared to normal subjects. Epithelioid cell granulomas were seen in BAL fluid in two patients.

Adult↗
PubMed1988

Glucocorticoid receptors in bronchoalveolar lavage fluid in sarcoidosis. A preliminary report.

Glucocorticoid receptor (GR) content was measured in bronchoalveolar lavage fluid (BALF) cells of 20 untreated patients with sarcoidosis. A significantly higher (p less than 0.001) lymphocyte count and GR content of BALF cells was noted in patients with sarcoidosis as compared to normal volunteers. The GR content correlated positively with lymphocytes (%) (r = 0.6; p less than 0.01) and was significantly higher (p less than 0.001) in patients who showed roentgenographic improvement, physiologic improvement, and improvement in both parameters compared to those who did not show improvement. Above findings suggest that the GR content of BALF cells is increased in sarcoidosis and a major contribution to this may be made by the lymphocytes.

Adult↗
PubMed1987

Bilateral recurrent spontaneous pneumothoraces in sarcoidosis.

A case of recurrent bilateral pneumothoraces is described in a young patient with sarcoidosis. An intercostal tube drainage was done for right sided pneumothorax. Patient was put on corticosteroid treatment and with this treatment there has been no recurrence of pneumothorax.

Adult↗
PubMed1986

The effect of nifedipine on exercise-induced asthma.

This article describes the effect of nifedipine, a calcium antagonist, on exercise-induced asthma (EIA). Effect of sublingual administration of 20 mg of nifedipine or placebo was studied in randomized double-blind manner on separate days in 19 extrinsic asthmatic subjects. Nifedipine was found to be significantly effective in abolishing the exercise-induced decrease in forced vital capacity (FVC) and maximal expiratory flows (p less than 0.001). There were no significant changes in heart rate and blood pressure after nifedipine.

Adolescent↗
PubMed1979

Double-blind, crossover comparison of carbuterol and salbutamol.

The bronchodilator efficacy of oral carbuterol in the dose of 2 mg or 3 mg was compared with that of 4 mg salbutamol in a double-blind, crossover trial in 21 patients with bronchial asthma. Carbuterol 3 mg was found to be a more effective bronchodilator than salbutamol 4 mg. Both the drugs in these doses produced mild tachycardia but were otherwise well tolerated.

Adolescent↗