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Biomedical subjects

J N Patton

Publications and source records attributed to J N Patton.

8 recordsLinked to original sources
PubMed1992

Coronary thrombolysis. Comparative effects of intracoronary administration of recombinant tissue plasminogen activator and urokinase.

We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of intracoronary administration of recombinant tissue plasminogen activator (rtPA) and urokinase (UK) on rate and extent of coronary thrombolysis. Two doses of UK, 15,000 U/kg (UK15) and 30,000 U/kg (UK30) and two doses of rtPA, 0.25 mg/kg (rtPA.25) and 0.75 mg/kg (rtPA.75) were given. Drugs were infused over 45 min. Compared with the other regimens, rate and extent of coronary thrombolysis were significantly increased with rtPA.75. Also, despite a much higher dose of UK, coronary thrombolysis was similar with UK30 and rtPA.25. Compared with UK15, rate and extent of coronary thrombolysis were increased with rtPA.25. These results indicate that intracoronary administration of rtPA is superior to intracoronary UK in inducing thrombolysis.

Animals↗
PubMed1991

Coronary thrombolysis with recombinant tissue plasminogen activator. Intracoronary vs intravenous administration.

We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of recombinant tissue plasminogen activator (rtPA) administered intravenously and administered directly into the coronary circulation. A control group did not receive rtPA. Compared with controls, both rtPA regimens induced coronary thrombolysis. However, compared with intravenous administration, rate and extent of coronary thrombolysis were increased with intracoronary administration. Most likely, the enhanced thrombolysis with intracoronary administration is explained by an increase in delivery of the drug to the thrombus.

Animals↗
PubMed1979

Current required for ventricular defibrillation.

The mean current required for ventricular defibrillation was measured and found to be 0.35 +/- SE 0.03 A/kg body weight, which is about one-third of that predicted from animal experiments. There was no apparent correlation between the current required and body weight (r = -0.007 +/- SE 0.213). There is no evidence of need for defibrillators storing more than 400 J.

Aged↗
PubMedDate not supplied

Cardiac masses: signal intensity features on spin-echo, gradient-echo, gadolinium-enhanced spin-echo, and TurboFLASH images.

Fifteen patients with cardiac or paracardiac masses underwent magnetic resonance (MR) imaging with spin-echo (n = 15), cine gradient-echo (n = 15), gadopentetate dimeglumine-enhanced spin-echo (n = 15), and TurboFLASH (fast low-angle shot) (n = 7) sequences. All masses had either histologic confirmation (n = 11) or confirmation with other imaging modalities (n = 4). Myxomas (n = 6) were characterized by an intermediate signal intensity (SI) on spin-echo (n = 6) and low SI on cine gradient-echo (n = 6) images and moderately high-SI contrast enhancement (n = 5). Percent contrast enhancement for myxomas was 57% +/- 11%. Thrombus (n = 4) had intermediate (n = 3) or high (n = 1) SI on spin-echo images and low (n = 2) or intermediate (n = 2) SI on gradient-echo images and did not show substantial contrast enhancement. Postcontrast first-pass TurboFLASH images were useful by clearly demonstrating the nonenhancing mass lesion in a high-SI blood pool. Other cardiac and paracardiac tumors (n = 5) showed variable pre- and postcontrast spin-echo SI; however, no other tumor showed low SI on cine gradient-echo images.

Adult↗