PubMed Health⌕ Search

Biomedical subjects

J N Sartoretto

Publications and source records attributed to J N Sartoretto.

12 recordsLinked to original sources
PubMed1978

Clinical evaluation of two biphasic and one triphasic norgestrel/ethinyl estradiol regimens.

Four hundred and fifty-eight women were followed for 3,586 cycles in a controlled, randomized, open trial designed to compare two biphasic and one triphasic norgestrel/ethinyl estradiol (ee) regimens. The three regimens are effective and no pregnancies were reported. Cycle control was good with all three regimens but the incidence of intermenstrual bleeding was higher with the triphasic. With this regimen, total hormonal ingestion is well below the lowest fixed dose norgestrel/ethinyl estradiol preparation (300 mcg norgestrel and 30 mcg ee) in the original 10:1 ratio. It is concluded that the staggering of hormonal doses opens the possibility of contraception with less hormone intake than is possible when a fixed dose regimen is used.

Contraceptives, Oral↗
PubMed1977

Low-dose combination oral contraceptives: a controlled clinical study of three different norgestrel-ethinyl estradiol ratios.

Three doses of norgestrel-ethinyl estradiol in altered ratios were investigated in a double-blind, randomized study. The estrogen content was maintained at 20 microng or less, while the progestogen dose was increased in 100-microng increments. Two pregnancies were reported for the lowest dose. No pregnancies occurred in the two higher doses. Each dosage increase improved cycle control and lessened bleeding irregularities. The incidence of patients reporting intermenstrual bleeding was inversely proportional to the doses studied. Dropouts for cycle disturbances followed a similar pattern.

Adult↗
PubMed1975

Evaluation of d-norgestrel 1.0 mg as a post-coital contraceptive.

Two hundred and ninety-eight women were followed for 2578 months (2739 'bleeding intervals') of treatment with d-Norgestrel 1.0 mg given as a post-coital oral contraceptive. Fourteen pregnancies were recorded (general failure rate, 6.5 per 100 woman/years); at least 6 of these patients did not miss any tablet (corrected failure rate, 2.8). The acceptability rates (life table method) were 0.58 and 0.40 after 6 and 12 months of follow-up. The most important medical reason for drop-out was cycle irregularities. The cycle pattern is deeply disturbed by this method of oral contraception.

Adolescent↗