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Biomedical subjects

J Naschitz

Publications and source records attributed to J Naschitz.

11 recordsLinked to original sources
PubMed2004

Midodrine treatment for chronic fatigue syndrome.

The long term results of midodrine treatment in a patient having debilitating chronic fatigue syndrome (CFS) are reported. Midodrine treatment, directed at the autonomic nervous system, resulted in correction of the dysautonomia followed by improvement of fatigue. This finding is consistent with the hypothesis that dysautonomia plays a major part in the pathophysiology of CFS and that therapies directed at the autonomic nervous system may be effective in the treatment of CFS.

Adult↗
PubMed2000

[Acipimox (Olbetam) as a secondary hypolipemic agent in combined hypertriglyceridemia and hyperlipidemia].

32 patients with hypertriglyceridemia, excessive hypertriglyceridemia, and combined hyperlipidemia, were treated with the nicotinic acid derivative acipimox (Olbetam). First line treatment with bezafibrate, or statins in some with combined hyperlipidemia, had failed. In 10 acipimox was discontinued due to side effects or absence of clinical response. The other 22 completed 6 months of treatment with no side effects. Acipimox caused a significant 54% decrease in triglyceride levels, a 23% decrease in total cholesterol, and a 12% increase in HDL-cholesterol. LDL-cholesterol was difficult to calculate because of the high triglyceride levels, so no results are presented. Although acipimox was much better tolerated than nicotinic acid, it also had side effects, but fewer. Acipimox can therefore be used as a second-line drug, mainly in those with combined hyperlipidemia and hypertriglyceridemia.

Adult↗
PubMed1996

[Hemorrhagic cystitis as a presenting symptom of acute infection with Salmonella typhi].

Salmonellae are frequently isolated from urine during the course of typhoid fever, although cystitis in typhoid is rare. In a young man who had returned from India with severe hemorrhagic cystitis, urine and bone marrow cultures confirmed the diagnosis of typhoid. Full recovery followed treatment with chloramphenicol. This case illustrates an unusual presentation of typhoid fever and the illustrates an unusual presentation of typhoid fever and the diagnostic difficulties occasionally encountered in patients returning from developing countries.

Adult↗
PubMed1988

Hereditary right axis deviation: electrocardiographic pattern of pseudo left posterior hemiblock and incomplete right bundle branch block.

We present a family with a hereditary electrocardiographic pattern of pseudo left posterior hemiblock and incomplete right bundle branch block which resulted in right axis deviation. The mother had a normal electrocardiogram, while the father and their two sons presented the above-described electrocardiographic features. Clinical, radiological and echocardiographic evaluation excluded structural and functional cardiac abnormalities as well as chest deformities and lung disease. The identical vectorcardiographic findings of the father and his sons is discussed.

Adolescent↗
PubMed1982

Hypertrophic apical cardiomyopathy: a subtype of hypertrophic cardiomyopathy.

This is the first report of hypertrophic apical cardiomyopathy outside of Japan. Electrocardiographic, vectorcardiographic, echocardiographic, hemodynamic and angiographic investigations support the view that this entity is a subset of hypertrophic cardiomyopathy that differs from hypertrophic obstructive cardiomyopathy and left-ventricular cavity obliteration. The ECG recorded giant negative T waves associated with prominent R waves in the precordial leads and septal Q waves were absent, with a normal mean QRS axis in the frontal plane. The vectorcardiogram showed a QRS loop oriented to the left anteriorly and inferiorly, while the T loop was characteristically discordant, elongated and situated in the right posterior quadrant. An M-mode ECG scan along the left-ventricular long axis revealed a marked increase in both septal and posterior wall thickness and excursions toward the apex. A characteristic spadelike configuration was observed in the left ventriculogram at end-diastole. Pressure studies at rest and after ventricular ectopic beats and isoproterenol provocation revealed no significant peak systolic pressure gradient within the left ventricle. This may have certain therapeutic implications.

Adult↗