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Biomedical subjects

J Navarro González

Publications and source records attributed to J Navarro González.

At least 19 recordsLinked to original sources
PubMed2000

[Effectiveness of smears and cultures in gastric aspirate samples in the diagnosis of tuberculosis].

AIM: To evaluate the effectiveness of smears and cultures in gastric juice samples in the diagnosis of childhood pulmonary tuberculosis and to assess the relationship between clinical, radiological and epidemiological parameters in children with tuberculosis. MATERIALS AND METHODS: Blind, prospective, controlled study of 421 gastric aspirate samples from 139 children referred because of suspected tuberculosis. Children were classified according to clinicoradiological factors, irrespective of microbiological results. To verify the clinical diagnosis an extended followup was carried out. RESULTS: Smears were positive in 6 of the 46 children with active tuberculosis (sensitivity: 13%) and in 3 of the 93 children in the control groups (specificity: 96.8%). Cultures were positive in 15 children with active disease (sensitivity: 32.6%) and effectiveness was greater when the chest radiograph showed parenchymal involvement. Mycobacterium tuberculosis was also isolated in two children with tuberculous infection who showed no apparent signs of the disease and in one of these children, CT scan revealed mediastinal adenopathies which were not evident on the chest radiograph. Mean growth time for positive cultures was 42 days. CONCLUSIONS: The sensitivity of smears and cultures in gastric aspirate samples of children with pulmonary tuberculosis is low. Results of culture take several weeks and smears can give false positive results. Some children with tuberculous infection without apparent signs of the disease show microbiological activity that can be caused by mediastinal adenopathies that are not evident on chest radiographs.

Adolescent↗
PubMed1996

[Computed tomography and polymerase chain reaction in tuberculosis infection in childhood].

The recognition of children with tuberculous infection without disease is often difficult. Minimal active disease may be present in many cases but unrecognised on chest radiography or by microbiologic methods. We have performed computed tomography in 22 children with tuberculous infection, a normal chest radiograph and negative microbacterial culture. In 16 children we also performed DNA amplification by polymerase chain reaction in gastric aspirates. It was found that 14 of 22 (63%) infected children had enlarged lymph nodes. Adenopathies were more frequent in children less than 8 years-old and in the right paratracheal positions. Polymerase chain reaction was positive in 4 of 8 studied children with abnormal computed tomography and in none of the children with normal computed tomography. The demonstration of unrecognised active disease raises the question of the adequate treatment for the children with tuberculous infection. It is proposed that a two drug regimen would be more appropriate than isoniazid alone in children less than 8 years old.

Adolescent↗
PubMed1996

[Repeat consultations in pediatric hospital emergencies].

The objectives of this study were to analyze the social and clinical aspects of the infant and child population who excessively utilize the hospital emergency services. To this end, the clinical histories of 130 children admitted to a pediatric hospital have been analyzed. These children were between the ages of 2 months and 10 years and had 10 or more visits to the emergency room or had more than 4 visits during the same year. The control group was arbitrarily composed of 270 children admitted to the same service during the same period of time. We found that in the study group the sociocultural level was low in 71% and 17% had serious social deprivation (significant differences with the control population, p < 0.05). Twenty percent had at least one previous febrile convulsion (p < 0.001) and 33% had more than four hospital admissions. No significant differences in the number of urgent consultations were found between the different days of the week no between the different months. The most frequent diagnosis was upper respiratory tract infections. The number of consultations was higher (p < 0.05) in children with serious social deprivation, chronic pathology, multiple hospital admissions and whose home was near the hospital. We conclude that children with reiterative consultations to the hospital emergency services usually have a social level lower than the control group. Most of these consultations are caused by banal problems and the children are subjected to an excessive number of analytical and radiological tests. Therefore, adequate health education is necessary among these sociocultural level groups in order to avoid using the emergency services as primary attendance consultations.

Child↗
PubMed1992

[Fever and petechial exanthema in children].

In an attempt to determine clinical and analytical predictive parameters of a possible grave disease, we have carried out a retrospective study of 172 children admitted to our hospital with fever and petechiae as initial symptoms. The ages ranged between 1 month and 10 years. Even though we have not found a clinical symptom or analysis sufficiently sensitive as to predict all grave diseases, the general clinical state of the child associated with either a high or low white cell count and an abnormal coagulation study should be alert signals for a serious infectious disease. On the contrary, if the clinical and analytical parameters are within normal limits the risk of a grave disease is low. We emphasize the high incidence of meningococcal disease (26%).

Child↗
PubMed1990

[Usefulness of the determination of free erythrocyte protoporphyrin in relation to other hematologic parameters in iron deficiency].

Hematological parameters and free eythrocyte protoporphyrin (FEP) on a capillary blood sample were measured in 175 apparently healthy children ranging from 6 months to six years of age. Thirty eight children had hematological parameters descended and/or FEP elevated were asked to return for blood counts, FEP, serum ferritin, serum iron, total iron binding, capacity, transferrin saturation and ALA-D activity, on a venous blood sample. Only 34 children returned. Twenty seven, 15.4%, had iron stores descended or iron deficiency, 18 of them with anemia. FEP had significant correlation coefficients with hematologic parameters (p less than 0.001), serum iron and transferrin saturation (p less than 0.01). On iron deficiency anemia detection, the FEP had a sensibility and specificity of 0.94 and 0.75 respectively.

Anemia, Hypochromic↗
PubMed1989

[Clinical evaluation of the stool culture in acute diarrhea].

173 children hospitalized with acute diarrhea are studied retrospectively with the object of finding clinico-analytic parameters suggestive of bacterial etiology. The 88 boys and 85 girls varied in age between 3 months and 10 years (only 20% were under a year). The children were divided into 2 groups: group D (+) were 39 children with positive stool cultures (salmonellas, 64%; campylobacter, 25%, and shigellas, 11%), and group D (-) were 134 children with negative stool cultures, and served as a control group. Various parameters were analyzed in order to define the socio-economic and nutritional status, and psychomotor development. Careful analysis was made of the patients' histories and exploratory findings, with special emphasis on the characteristics of the feces. Using the chi-square statistical analysis, significant differences between the two groups were found in relation to length of hospital stay, which was longer in group D (+) (p less than 0.001), the appearance of blood in stool, more often in group D (+) (p less than 0.05) and in the number of children of group D (+) with band forms greater than 10% (p less than 0.05). In accordance with our findings, the practice of stool cultures should be limited to those patients with acute febrile diarrhea presenting macroscopic blood in stool and leukocytosis with neutrophilia (excepting children under 3 months of age, those in a critical or malnourished state, immunodepressed or in a particular epidemic situation). In this way the number of stool cultures and medical assistance costs would be markedly reduced and a more adequate cost/benefit relation would be obtained.

Bacteria↗
PubMed1988

[Calcification of the intervertebral disk in children].

Authors present two cases of calcification of the intervertebral disc. They provide an analysis of etiology, symptoms, and roentgenographic clinic course, as well as a review of cases which have been reported in literature.

Calcinosis↗
PubMed1988

[Abdominal echography in recurrent abdominal pain: study in 100 cases].

Abdominal ultrasound imaging performed in 100 children with recurrent abdominal pain have been reviewed. Organic abnormalities were found in 7% of cases. It is emphasized the importance of a careful clinical history, physical examination as well as biological and bacteriological investigations before abdominal echography. In spite of that we believe abdominal ultrasonography is useful in this type of patients, even when non-organic causes are suspected, because of its harmlessness. If the study were normal, others more aggressive explorations could be avoided.

Abdomen↗
PubMed1986

[Ischemia after intramuscular injection of benzathine penicillin].

Two cases of ischemia produced by arterial spasms following an intragluteal injection of benzathine-penicillin which have been solved successfully are reported. Authors review literature on this subject and warn of the serious problems that may happen with this procedure.

Buttocks↗
PubMed1982

[Intervertebral disk infection in children (author's transl)].

Discitis, or infection of an intervertebral disk, is a diagnostic challenge in the preschool age, unless there is good reason for suspicion. Two children, two and four years old, are discussed here. They had abdominal pain for several days, difficulty in movement and anomalous sitting postures. In both, L4-L5 was affected, and laboratory, including bacteriology, studies were negative, except for leucocytosis and slight-to-moderately elevated sedimentation rates. The diagnoses were confirmed by lumbar spine X-rays, though not until the third week after onset of symptoms. Discussed are the values of bone gammagraphy in early diagnosis, favourable clinical evolution in spite of an abnormal radiological picture, and treatment.

Abdomen↗
PubMed1980

[Visceral leishmaniasis in childhood (author's transl)].

Authors present six cases of kala-azar in children under six years of age observed in the province of Seville, during a three year period. Ethiologic, clinical, evolutive and therapeutic aspects of this illness are analized. Two of the patients presented jaundice, in which a liver-spleen scan was performed and nothing else but the hepato-splenomegaly was found, as it was described in a previous case. Importance of visualizing leishmanias by bone marrow puncture for a true diagnosis is remarked.

Age Factors↗
PubMed1979

[Sleep apnea in a child with adenotonsillar hypertrophy (author's transl)].

A three year old with sleep apnea due to adenotonsillar hypertrophy is presented. The picture improved after treatment with antibiotics and corticosteroids, and disappeared after adenotonsillectomy. The symptomatology is studied in relation to primary alveolar hypoventilation and the "sudden death" syndrome in infants. The need of an early diagnosis is emphasized to avoid onset of an irreversible "cor pulmonale". It is suggested that aside from a probable predisposing "central" and constitutional factor in children with this syndrome, apparently there are heterogeneous electroencephalographic sleep patterns.

Adenoids↗
PubMed1979

[Kawasaki's disease. a case presentation].

A case of Kawasaki's disease in a girl of 2 10/12 years of age is presented. She had a typical clinical picture, without cardiovascular afectation, and with good final results. Apparently this is the third case reported in the Spanish medical literature. Attention is called to the low incidence of MLNS in the western countries--only 50 cases reported--as compared with the great number reported from Japan. The problems of diagnosis and pathogeny are discussed, particularly their intimate relation to infantile polyarteritis nodosa, because of the similarities in the cardiovascular alterations in both processes, above all in mortal cases.

Child, Preschool↗