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Biomedical subjects

J Nazer

Publications and source records attributed to J Nazer.

43 records · Page 3Linked to original sources
PubMedDate not supplied

[Genetic study in twins].

During the period june 1987-January 1988, 35 consecutive pairs of twins born at two maternity hospitals in the northern area of Santiago were studied to search evidence of genetic or other factors which could eventually favour twinning. Sixteen of these pairs were considered to be monozygotic (MZ) after studying five blood group systems (ABO, Rh, MNSs, Duffy and Kidd) applying the method of Smith and Penrose. Maternal age was higher in dizygotic twins (DZ) than in the MZ group (average 30.1 yrs. v/s 26.8 yrs. respectively (p < 0.05). Family history of twinning was positive in 73% of the MZ and in 82% of the DZ twins. The Duffy and Kidd systems were not in Hardy-Weinberg equilibrium due to a deficit of heterozygotes in MZ as well as in DZ twins. There was a significant increase in MS and Ms haplotypes in both groups of twins respect to the Chilean general population (p = 0.01). These results suggest the presence of a genetic determinant that favors the production of twinning of DZ as well as MZ type. A larger number of cases will be required to test this hypothesis.

Blood Group Antigens↗
PubMedDate not supplied

[Incidence of 50 congenital malformations in 8 Chilean maternities participating in the Latin American Study of Congenital Malformations (ECLAMC). 1982-1988].

The incidence of 50 congenital malformations detected among 106,457 consecutive deliveries, in 8 chilean maternities participating in ECLAMC (Latin American Study for Congenital Malformations) is presented. The global incidence of congenital malformations was 2.97 for every 100 newborn infants. 2.92% in live borns and 8.54% in stillborns respectively. The mortality among the whole live borns of this series was of 0.93%. The incidence of congenital malformations in chilean maternities was compared with the rest of ECLAMC and significant differences were found in many of them, being higher in some problems where more complex diagnostic methods are required and were available, as is the case with congenital heart disease (23.85% vs. 9.72%) and renal agenesia (2.07% vs. 0.6%). In other types of more obvious abnormalities there were differences which could be eventually attributable to genetic or environmental factors.

Chile↗
PubMedDate not supplied

[Incidence of congenital malformations among stillborns].

During the period 1982-1986 there were 168 stillbirths out of 20,669 consecutive deliveries (0.81%) at the University of Chile's Clinical Hospital. The incidence of congenital malformation was 6.26% in the liveborn population and 14.29% in the stillborns. There was a significant statistical difference between these two groups of malformed newborns regarding maternal age, parity and birthweight. The incidence rate of ten selected major congenital anomalies in the two groups showed highly significant differences, being higher among stillborns.

Chile↗