Biomedical subjects

J Nemcsók

Publications and source records attributed to J Nemcsók.

42 records · Page 3Linked to original sources

PubMed1982

Comparative studies on the sensitivity of different fish species to metal pollution.

The effects of 10 ppm CuSO4, ZnCl2 on the blood glucose level and serum LDH, GOT, GPT activities of three fish species (carp, silver carp, European wels) were measured. CuSO4 increased the blood glucose level, LDH, GOT and GPT activities in the three species in the following order: silver carp greater than carp greater than European wels. ZnCl2 did not alter the same levels. Our results showed that CuSO4, and presumably several anthropogenic agents, damaged the different fish species specifically and caused different stress effects depending on the fish species.

Alanine Transaminase↗

PubMed1979

Differences in uptake of labelled serotonin, dopamine and noradrenaline by the CNS and other tissues in Anodontacygnea L., depending on the activity of the animal.

Among monoamines injected intracardially during activity, 3H-serotonin was taken up by the kidney, while 3H-dopamine and 3H-noradrenaline by the ganglia in the highest amount. The uptake of the labelled monoamines in the corresponding tissue was significantly lower during rest.

Animals↗

PubMed1977

Monoamine level and periodic activity in 6-hydroxydopamine treated mussels Anodonta cygnea L.

In the central nervous system of the mussel (Anodonta cygnea) 6-hydroxydopamine (6-OHDA) causes a significant and prolonged decrease in the dopamine (DA) and noradrenaline (NA) concentration. The decrease of serotonin (5HT) level did not exceed 25 per cent and was observed only on the 2nd and 3rd day after the treatment. Parallel with the alteration of the monoamine level, there is a marked change in the activity of the animals. Two phases of the effect of 6-OHDA can be distinguished. During the first phase, not only the catecholaminergic but, presumably, also the serotoninergic system is injured. The long-lasting effect of the 6-OHDA administration is reflected in the predominance of the active periods and in the absence of rest periods of the animal.

Animals↗

PubMed1977

Ultrastructural effects of 6-hydroxy-dopamine and 5, 6-dihydroxytryptamine on the central nervous system of fresh-water mussel, Anodonta cygnea L.

Ultrastructural effects of 6-hydroxydopamine and 5, 6-dihydroxytryptamine treatments were investigated in the central nervous system of fresh-water mussel. Two days after the treatments, the following characteristic find-structural alterations could be observed in the neuropil of the ganglia: frequent occurrence of multilamellar bodies, lysosomatic structures and elongated tubular forms; shrinking of varicose axon profiles with an enchancement of the density of the axoplasm and clumping of its content; abnormal swelling of certain axons in the neuropil. This degenerative process was accompanied by an intense phagocytosis. The damages evoked by the employed "false transmitters" in the mussel ganglia were, in general, similar to those found in vertebrates. Statistical analysis of the vesicle population of ganglia suggests the intragranular uptake of 6-hydroxydopamine and 5, 6-dihydroxytryptamine and, in addition, the role of dense-core vesicles of different types in the storage of both serotonin and catecholamines. Perikarya composing the cortical layer of the ganglia were not affected by the "false transmitters". This shows that different parts of a mussel neuron are differently sensitive to 6-hydroxydopamine and 5, 6-dihydroxytryptamine.

5,6-Dihydroxytryptamine↗

PubMed1976

Dry weight and 5HT concentration in the cerebral ganglia of Anodonta (Mollusca) during activity.

As shown by interferometry, the amount of protein in neuron bodies of Anodonta cygnea L. cerebral ganglia changed in direct relation to the duration of the active state of the mollusc. The amount of serotonin in cerebral ganglia changes independently of the amount of protein in nerve cells, although it varies consistently with the activity and rest of the animal.

Animals↗

PubMedDate not supplied

The effects of pesticides on some biochemical parameters of carp (Cyprinus carpio L.).

Treatments with copper sulphate (CuSO4), paraquat (PQ) and methidathion (MD) caused tissue damage and stress effects in carp, indicated by the increased lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT), and glutamate dehydrogenase (GIDH) enzyme activities and elevated blood-sugar levels. Copper sulphate, administered together with PQ and MD, were synergistic in terms of tissue damage and stress effects. The isoenzyme patterns showed organ-specific tissue damage. The administered chemical and isoenzymes indicating liver damage were detectable in the blood. The combination of CuSO4 and MD caused focal cell necrosis, which was observable in the liver tissue by light microscopy. Electron microscopic studies revealed the presence of damaged parenchymal cells with electron transparent cytoplasms, myelin figures, and altered mitochondria ER and Golgi.

Animals↗