Treatment of hepatosplenic Schistosomiasis mansoni with praziquantel. Preliminary report on tolerance and efficacy.
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Biomedical subjects
Publications and source records attributed to J Neves.
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A sample of 45 algerian women and a sample of 125 french women of the same age and marital status are compared on their state of psychological well, or illbeing. All the probands were extracted from the general population. Our measurement of "impairment in daily life" appears to be a reliable detector of light or more consequential depression. This syndrome covers almost the whole range of the psychopathology we have found, and its structure is essentially the same in the French and Algerian samples. The one-year prevalence of depressive syndrome for the two samples combined (n = 170) is 15% for the mildly impaired and 3% for the more markedly impaired. The intercultural comparison shows a statistically significant difference between the two samples, the algerian women being relatively more depressed. When the entire sample is divided into sub-groups, the results show a close relationship between global life conditions and mental health. In particular, the women who go out to work and like their activity are the most symptom-free.
Two families, comprising 11 individuals in the toxemic form of schistosomiasis mansoni, infected in Belo Horizonte, Brazil were treated. Parasitological cure was obtained in 5 (45%) of the patients after a single oral dose of oxamniquine (Mansil), 20 mg/kg body weight. No significant side effects were observed. To evaluate the possibility of resistance to the drug, cercariae collected from Biomphalaria glabrata infected with micracidia from eggs obtained from three of the individuals not cured were studied. Mice infected with these three strains were cured after a single dose of examniquine. It is suggested that research be continued with other therapeutic schedules and perhaps other, more potent, drugs.
Double electroimmunodiffusion (EID) was adapted for detection of antibodies to Coccidioides immitis. In a limited experiment with canine serums, the test was found to be qualitatively as sensitive as the complement-fixation (CF) test. Advantages of EID over CF are that EID takes only 30 minutes to perform and requires only 10 mul each of antigen and antibody.
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