[Note on serum lipids in T. Gambiense trypanosomiasis].
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Adolescent↗
Biomedical subjects
J Nicoli
Publications and source records attributed to J Nicoli.
[Colorimetric microdetermination of neutral oses with sulfuric acid and phenol. Influence of salts and proteins].
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Chemical Phenomena↗
[Cancers, oncogenesis and oncogenes].
The carcinogenic transformation depends on the presence of particular genes, the oncogenes, which are, as a matter of fact, normal cellular genes. The oncogenic retro-viruses are mosaic genomes, transducing oncogenes in the infected cells. These genes are expressed: the product has an activity of protein kinase. The expression is increased in the transformed cells, because the oncogenes are either linked to strong viral promoters in the oncogenic viruses, or translocated in the vicinity of immunoglobulin genes in the case of Burkitt lymphoma. Moreover, there is some modifications (punctual mutations or deletions) of the primary sequence of the protein.
Animals↗
[Polyuridylic sequences and negative strands of Sindbis virus-specific RNAs: study by affinity chromatography on poly (A)-sepharose columns (author's transl)].
The experimental conditions of affinity chromatography on poly (A)-Sepharose columns have been determined. This method makes obvious the existence of polyuridylic acid sequences on the negative strands of Sinbis virus-spedific RNAs. The isolated RNAs are negative and positive strands hybrids. By polyacrylamide gel electrophoresis, it has been shown that the negative strands have the same length as the 26 S interjacent RNA at the 6th hour, and as the 42 S virion RNA at the 9th hour postinfection. The polyadenylic acid sequences of the virion RNA and of the replicative intermediate are therefore probably genetically coded.
Base Sequence↗