PubMed Health⌕ Search

Biomedical subjects

J Nováková

Publications and source records attributed to J Nováková.

At least 19 recordsLinked to original sources
PubMed1994

A genetic profile of Romany (Gypsy) subethnic group from a single region in Slovakia.

The data presented here are on population structure and genetic markers (ABO, RH, MN, HP) in two series of so-called Slovak Romany subethnic groups from a single region (Gemer) in the Southeastern part of Slovakia. The results demonstrate that favourable conditions have existed for population genetic mechanisms operating in isolated populations, namely genetic drift and inbreeding. In addition, an attempt was made to compare the observed data with those available for other Romany populations and for Slovaks.

Blood Group Antigens↗
PubMed1993

Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.

Single as well as paired responses to stimulation of the contralateral sensorimotor cortex were recorded in adult and 12-day-old rats under urethane anesthesia. Carbamazepine (50 mg/kg i.p.) prolonged the peak latencies of single responses in both adult and young rats, while phenytoin (60 mg/kg i.p.) prolonged the latencies in adult animals but shortened them in the young ones. Excitability cycles of the amplitude of the initial positive-negative complex remained uninfluenced by either drug in both age groups. Since solvent alone did not induce any effects in either test, our results demonstrate a qualitative change in the action of phenytoin during development.

Aging↗
PubMed1992

Acetylcarnitine, carnitine and glucose diminish the effect of muscarinic antagonist quinuclidinyl benzilate on striatal acetylcholine content.

The content of acetylcholine (ACh) in the striatum, brain cortex and hippocampus of rats was lowered 20-180 min after intraperitoneal injection of the muscarinic antagonist quinuclidinyl benzilate (QNB). The depletion of ACh content in the striatum was diminished in animals treated with a single dose of acetyl-L-carnitine, L- or D,L-carnitine, or D-glucose. It is likely that QNB stimulates ACh release by blocking presynaptic muscarinic autoreceptors and that acetylcarnitine, carnitine and glucose support the resynthesis of ACh by increasing the availability of acetylcoenzyme A. They do not have the same consistent effect in the brain cortex and hippocampus; this difference may be related to the lower turnover rate of ACh and to the difference in the anatomical arrangement of cholinergic structures in these parts of the brain.

Acetylcarnitine↗
PubMed1992

[Results of detection of hepatitis C virus antibodies (anti-HCV) in blood donors and selected patients].

The authors examined 509 donors for potential carriership of the virus of hepatitis C (HCV), using kits for the detection of anti-HCV. Concurrently they examined also 110 hameatological patients who had a major transfusion of blood, plasma and its derivatives. They found that in the so-called healthy population anti-HCV is present in 0.39%. In haematological patients, i.e. patients with frequent haemotherapy they detected 29 positive cases, i.e. 26.36%. The largest number of anti-HCV positive patients was in the group of haemocoagulopathies. The investigation confirmed the close association between haemotherapy and the transmission of HCV. The authors draw attention to the need to introduce anti-HCV examinations in the transfusion service as an important preventive provision.

Blood Donors↗
PubMed1990

Acute phase proteins and prognostic inflammatory and nutritional index (PINI) in moderately burned children aged up to 3 years.

In 27 children (12 boys and 15 girls) aged 3 months to 3 years, the plasma levels of albumin, prealbumin, orosomucoid and C-reactive protein (CRP) were determined after burn trauma. The results of these measurements were used to calculate the prognostic inflammatory and nutritional index (PINI). The children were assigned to two groups: a group with burns covering less than 10 per cent of the body surface area (BSA) (minor burns), and those with burns covering 11-20 per cent BSA. The lesions involved were either dermal burns (Class IIB) or full skin thickness burns (Class III). While the group with minor burns showed only a small decrease in albumin and prealbumin levels, the decrease in children with extensive burns was well below values on the first 7 days. On days 2, 5 and 7 after burning, the differences between both groups were statistically significant. Orosomucoid levels were somewhat elevated in the group with extensive burns. This difference, however, was not statistically significant compared with the group with minor burns whose values were slightly below the normal range. The levels of C-reactive protein were statistically significantly increased in children with extensive burns compared with those with burns. The PINI value correlated positively with the burn area given in per cent (for day 5 of follow-up, the regression line equation was y = 9.346 + 1.65 x). These data indicate that there are no pronounced changes in plasma protein levels in the group with minor burns.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute-Phase Proteins↗
PubMed1990

[Validity of routinely used methods of testing glomerular filtration in pediatric practice].

The authors compare different methods used commonly in paediatric practice to assess glomerular filtration (GFR)--creatinine clearance and assessment of GFR by means of Schwartz formula with plasma clearance of polyfructosan S (corresponds to inulin plasma clearance). A group of 108 children aged 4-16 years (x = 10.95) was examined. The patients were divided into three groups by the magnitude of polyfructosan S clearance: greater than 100 ml/min/1.73 m2; 50-100 ml/min/1.73 m2 and less than 50 ml/min/1.73 m2. The authors correlated the clearance of polyfructosan S with creatinine clearance and assessment of GFR according to Schwartz. The method which proved to be most sensitive for detection of reduced GFR in the area of 50-100 ml/min/1.73 m2 was creatinine clearance with urine collection one hour after a previous water load (r = 0.748). In the stage of chronic renal failure with GFR less than 50 ml/min/1.73 m2 the correlation was close with the three-hour creatinine clearance (r = 0.957) and equally close was the correlation with GFR according to Schwartz (r = 0.885). The authors discuss the probability of detection of impaired GFR by commonly used methods and draw attention to the advantages of examination of plasma clearance by polyfructosan S.

Adolescent↗
PubMed1989

[Immunologic response to inflammation and trauma in children].

Inflammation and injury influence plasma proteins and immunoglobulins. They respond to noxious agents by a rise of c-reactive protein (CRP), orosomucoid, fibrinogen, haptaglobulin, alpha-1 antitrypsin, ceruloplasmin, C 3 and C 4 components of complement. The rate of rise and return to normal values varies. CRP reacts most'promptly. The following substances react by a decline of the levels: albumin, prealbumin, transferrin, alpha-1 lipoprotein and immunoglobulins. Investigation of the patient's immunological state is of prognostic value. CRP, orosomucoid, albumin and prealbumin are considered the most valuable indicators; from their values the so-called PINI index can be calculated and the patients can be divided into five prognostic zones. To threatened patients all-round care must be devoted incl. aimed provision of ATB and immunoprotective substances.

Acute-Phase Proteins↗
PubMed1989

[Hyperandrogenic states in girls and young women].

The authors present a group of 20 girls and young women with various clinical symptoms of hyperandrogenism. The common finding in all these patients is an elevated excretion of desoxy-fraction of 17-oxosteroids, in particular androsterone in urine. The authors describe in detail the case-history of a girl with pubarché praecox and premature closure of the epiphyseal crevices and a young woman with polycystic ovary syndrome. The authors supplement the reflections on the aetiology of hyperandrogenism by suggestion of an algorithm examination and therapeutic procedure when excessive androgen production in the female organism is confirmed.

Adolescent↗
PubMed1989

[Follow-up of burn injuries using the PINI index].

In the submitted paper the authors evaluate the influence of medium extensive burns injury on levels of selected plasma proteins in 27 children aged three months to three years. The assessed albumin, prealbumin, C-reactive protein and orosomucoid were used for calculation of the so-called PINI index [prognostic inflammatory and nutritional index]. The PINI index summarizes in a suitable way the impact of injury on the metabolism of plasma proteins in burned children under three years of age. It differentiates the group with mild injuries from the group with extensive burns. It drop correlates with the improving clinical condition of the patient and it can be used for the monitoring of the burned child.

Blood Proteins↗
PubMed1987

The possible mutagenic effect of the occupation of TV announcer.

In a group of TV announcers, a significant increase in the number of classical aberrations was detected in peripheral blood: 7.5 +/- 3.477% in comparison with 3 control groups (A - 7 healthy women matched for sex, age and place of residence, B - 9 members of TV technical staff, C - 9 actors and actresses) with a mean aberration level of 2.96 +/- 1.136. SCE numbers were not increased in the TV announcers compared to controls. An increased frequency of reproduction failure has also been noticed in TV announcers (females). A decrease in the level of aberrant cells was noticed when the announcer had been on holiday, although this was not statistically significant. The possible mutagens in the working environment of TV announcers are discussed; there is a suspicion that azodyes, present in cosmetics or other chemicals, may be the mutagenic factor.

Chromosome Aberrations↗