Biomedical subjects
Publications and source records attributed to J O Ayanru.
The case reports of three patients who were seen at the University of Benin Teaching Hospital Benin City with a diagnosis of solar maculopathy are presented. There was good visual recovery in two of the patients. This report shows the effect on the retina of direct sun gazing. The need to use protective filters is emphasized.
A case of tuberculoma of the eye is reported occurring in a 3-year-old girl. Clinically presenting as a case of leucocoria a pre-operative diagnosis of retinoblastoma was made, necessitating enucleation of the eye. Post-operatively a diagnosis of intraocular tuberculosis was made. The differential diagnosis is discussed and the importance of inclusion of intraocular tuberculoma in the differential diagnosis of retinoblastoma is stressed.
A review of conjunctival, episcleral and corneal diseases seen in Bendel State in the South of Nigeria shows significant differences in the pattern of conjunctional and corneal diseases. Onchocerciasis and trachoma which cause much ocular morbidity and blindness in the savannah north have little place in the rain forest areas of southern Nigeria. The relative rarity of herpetic dendritic ulcers and corneal dystrophies are highlighted while the major indication for keratoplasty in southern Nigeria is leucoma associated with measles or trauma. The place of measles immunisation, improved nutrition and treatment for xerophthalmia is emphasized.
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A review of 1987 patients with uveitis seen over an 11-year period in Bendel State of Nigeria has been undertaken; 56% of cases had a posterior/mid-peripheral uveitis, 15.1% a panuveitis, 21.5% an anterior uveitis. Acute anterior uveitis with classical symptoms was rarely seen. Its comparative rarity is presumably due to the absence of HL-A27 in Africans and altered immunological states from malaria and parasitic infections. Identified aetiological factors in anterior uveitis were leprosy (1 patient), tuberculosis (1 patient), herpes zoster (16 patients), and onchocerciasis (3 patients). The great majority of cases of posterior uveitis were of presumed toxoplasmic origin. Further studies are needed to demonstrate its mode of transmission in a population in which toxoplasmosis is endemic. Forest onchocerciasis is not a major cause of uveitis in southern Nigeria in the same way as savanna onchocerciasis is in northern Nigeria. Syphilis seems to play no part in the causation of uveitis in southern Nigeria. Better diagnostic facilities are required to determine the role of sarcoidosis and other possible causative factors. Uveitis is a major cause of blindness in Nigeria.
One hundred and seven patients from the Mid-Western State of Nigeria with the tropical amblyopia syndrome are reported. Ninety-five patients (88.8%) had the amblyopia syndrome mainly; twelve patients (11.2%) had amblyopia and other manifestations of the tropical ataxic neuropathy. The young, aged 10-20 years, represented by sixty-six patients (61.8%), are predominantly affected by the uncomplicated syndrome. Thirteen patients (12.1%) showed muco-cutaneous evidence of avitaminosis. Fifty patients (46.7%) had temporal pallor of the optic discs, bilaterally, another fifty (46.7%) had normal discs, two (2.8%) showed pink discs. Generalized field constriction is the common field defect, though central or centro-caecal scotoma can occur. Red/green defect was present in seven patients. It is a disease of the poor or those living on a basic monotonous diet consisting mainly of cassava (mannihot) and its derivatives. It is a significant cause of defective vision in Mid-Western Nigeria.
The major blinding conditions in the Midwestern State of Nigeria are cataract (33.2%), uveitis (20.4%), chronic simple glaucoma (17.1%), trauma(7.9%). The primary causes of uniocular blindness are uveitis (28.3%), cataract (23.9%), chronic simple glaucoma (13.2%), trauma (9.9%). Comparisons of the main causes of blindness in Midwestern, Northern, Western and Eastern Nigeria and Great Britain are made.
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