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Biomedical subjects

J O Greenberg

Publications and source records attributed to J O Greenberg.

At least 19 recordsLinked to original sources

Magnetic resonance imaging of the lumbar spine in asymptomatic adults. Cooperative study--American Society of Neuroimaging.

We performed magnetic resonance imaging of the lumbar spine on 66 asymptomatic subjects and found that 12 (18%) had either a disc protrusion or herniation. An additional 26 (39%) had a bulge that was associated with degenerative disc disease. We also found examples of spinal stenosis, narrowed nerve root canals, osteophytes, and vertebral body involvement with multiple myeloma. Degenerative disc disease is a common finding in asymptomatic adults that increases in frequency with age. It occurs more frequently in men and usually involves more than one level. The most common location is L5-S1.

Adolescent↗

Neuroimaging of the spinal cord.

Neuroimaging of the spinal cord has taken on new dimensions in the past few years. With improvement in surface coils, elimination of artifacts, and fast scan imaging, myelography with all of its complications is on the wane. Computerized tomography is excellent for bony abnormalities, but most patients with spinal disease can be diagnosed with magnetic resonance imaging due to its excellent contrast, spatial resolution, and ability to actually see the spinal cord. However, at times CT is extremely helpful. This article reviews neuroimaging of the major diseases affecting the spine.

Humans↗

Neuroimaging in brain swelling.

Modern neuroimaging techniques have added to the understanding of brain edema and its earlier diagnosis. It is now possible to quickly know whether a lesion is focal with associated pressure effects or whether the symptoms are due to a diffuse process whose treatment may be different. The various herniation syndromes can be appreciated on the CT without risk to the patient. The neuropathologic proof of earlier pathophysiologic theories of three types of edema (vasogenic, cytotoxic, and interstitial) caused by various diseases need no longer wait for the autopsy specimen; it is strongly suggested by modern neuroimaging techniques. Some disease entities (meningitis, trauma, ischemic infarction) are characterized by several types of edema, depending on when the patient is examined. Swelling of the brain is an important topic to study not only because it is common, but also because it may be fatal. Neuroimaging in brain swelling has led to new knowledge regarding this important subject. This review is primarily that of the computerized tomogram in diagnosing both focal and diffuse swelling of the brain and some basic understanding pathophysiologically that would allow one to explain the image obtained. Because edema is primarily water, it seems likely that magnetic resonance imaging will shed even further light on this intriguing subject.

Blood-Brain Barrier↗

Computed tomography in brainstem hemorrhage.

Seven of eight patients had a clinical diagnosis other than brainstem hemorrhage before computed tomography (CT). Four were diagnosed as infarction, one as intracerebral hemmorrhage, one as hypertensive encephalopathy, and one as subdural hematoma. All survived except one, who died of pulmonary embolus. Although the yeild of posterior fossa lesions on CT is thought to be small, our experience indicates that CT is exceedingly valuable in demonstrating and localizing brainstem hemorrhage. The prognosis of brainstem hemorrhage appears to be better than reported in the literature.

Aged↗

The mega cisterna magna.

Eleven cases of enlarged cisterna magna were found in a series of 3000 computerized tomography scans. We believe mega cisterna magna by itself is not related to any specific symptoms and may not require further study or treatment.

Adolescent↗

Sleep deprivation and electroencephalographic abnormalities.

Thirty-three patients suspected of having a seizure disorder had routine electroencephalograms (EEG's) followed by post-sleep deprivation (P-SD) EEG's. The P-SD EEG's revealed abnormalities in 33% of those patients with a normal routine EEG. All of those patients with P-SD activation had histories highly suggestive of a seizure disorder. Most patients with normal P-SD EEG's were not highly suspect for seizures, however, several patients with probable seizures were also normal P-SD. Most patients with abnormal routine EEG's continue to show comparable abnormalities P-SD, with enhancement of abnormality in some cases and diminished abnormality in few cases.

Adolescent↗

Unexpected brain hemorrhages and the value of computerized tomography.

Intracerebral hemorrhage has been thought in the past to be manifested by sudden onset of hemiplegia, severe headache and deep coma proceeding to death in most cases. There are patients who present with less ominous symptoms who have heretofore been though to have cerebral infarction or transient ischemic attacks who in reality have intracerebral hemorrhages. Computerized tomography has allowed us to identify these patients and to separate them from the large group of patients with ischemic infarcts either due to thromboses or emboli. Six patients were reported with unexpected brain hemorrhages and their good prognosis is emphasized.

Adult↗

Idiopathic normal pressure hydrocephalus-- a report of 73 patients.

In 1973 we reported results of ventricular shunting in 28 patients with idiopathic normal pressure hydrocephalus. The present report consists of a three year follow-up of the latter (series 1), and an additional 45 patients (series 2) are presented for further insight into the conclusions drawn from the original experiences.

Adult↗

Ventricular size after shunting for idiopathic normal pressure hydrocephalus.

It has been presumed that idiopathic normal pressure hydrocephalus is due to obstruction. We visualized the ventricles in 19 patients subsequent to shunting. We found no consistent relationship between clinical improvement after shunting and reduction in ventricular size. This suggests that the positive effect of shunting in at least some instances is due to some other factor than reduced ventricular size.

Aged↗