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Biomedical subjects

J O King

Publications and source records attributed to J O King.

At least 19 recordsLinked to original sources
PubMed1996

Epilepsy in the nevoid basal-cell carcinoma syndrome (Gorlin syndrome): report of a case due to a focal neuronal heterotopia.

We present a case of uncontrolled temporal lobe epilepsy due to a focal left temporal neuronal heterotopia associated with the nevoid-basal-cell carcinoma syndrome. This is the first pathologically described lesion associated with temporal lobe epilepsy in this syndrome. Because the patient's seizures resolved after a modified left anterior temporal lobectomy, this case illustrates that epilepsy in patients with the nevoid basal-cell carcinoma syndrome is potentially curable and should be investigated appropriately.

Adolescent↗
PubMed1995

Cerebral venography and manometry in idiopathic intracranial hypertension.

Cerebral venography and manometry in nine patients with idiopathic intracranial hypertension consistently showed venous hypertension in the superior sagittal sinus and proximal transverse sinuses, with a significant drop in venous pressure at the level of the lateral third of the transverse sinus. The abnormality, clearly demonstrated by manometry, was not well shown on the venous phase of cerebral angiography. The appearance of the transverse sinus on venography varied from smooth tapered narrowing to discrete intraluminal filling defects that resembled mural thrombi. Two patients with intracranial hypertension due to minocycline did not show venous hypertension.

Adolescent↗
PubMed1983

Rhinocerebral mucormycosis.

Two cases of rhinocerebral mucormycosis are reported to draw attention to this fulminating fungal disease. Both patients had diabetes, and presented with a rapidly progressive orbital apex syndrome.

Adolescent↗
PubMed1983

The inclusion of ground hay, straw and paper in the diets fed to growing rabbits.

In 3 experiments growing rabbits were divided into 2 groups. In each case half received a basal ration while the other half was given this ration supplemented with a ground fibrous material: 20% hay, 10% straw or 10% paper. All the diets were fed in pelleted form. In all the experiments the rabbits fed on the diets containing the added fibrous materials gained in weight slightly more rapidly and had slightly higher food conversion ratios than did those on the control diet, but the differences in the means were not significant. A study of the small intestine and caecum weights expressed as percentages of body weight and as the weights of 1-cm lengths showed that the added fibrous materials increased these weights except in 1 instance where the results were the same. Significant changes were recorded in the case of hay in both the percentage weight and the weight of 1-cm lengths of caecum and in the straw experiment in the weight of 1-cm lengths of small intestine. There were no significant changes in the results from the paper-fed rabbits.

Animal Feed↗
PubMed1981

Husbandry methods predisposing to production diseases in dairy cows.

Errors in management, other than nutrition, which can be predisposing causes of disease, eg, walking on abrasive surfaces and prolonged standing in slurry (which precipitate lameness), faulty milking and a dirty environment (which are conducive to mastitis), breeding to produce oversized fetuses (leading to dystocia) and inefficient observation (leading to a failure to detect oestrus) are described. Nutritional factors affecting conception rates and the occurrence of the metabolic diseases, ketosis, hypocalcaemia and hypomagnesaemia are outlined.

Animal Husbandry↗
PubMed1981

Optic nerve decompression in benign intracranial hypertension.

Fourteen patients with benign intracranial hypertension who failed to respond to medical treatment, were treated with optic nerve decompression to prevent the sequelae of chronic unrelieved papilloedema. The mechanism by which optic nerve decompression protects the optic nerve is uncertain. These patients were reviewed to evaluate the efficacy of the procedure in the treatment of benign intracranial hypertension and to assess its mechanism of action. Preoperatively all patients had papilloedema, 11 patients had visual obscurations and 6 patients had evidence of visual failure. Postoperatively, visual obscurations and papilloedema resolved in all patients, and 5 of 6 patients had no further deterioration of visual function. Six patients had symptoms of raised intracranial pressure preoperatively and in 3 the symptoms resolved after surgery. Three patients had unilateral optic nerve decompression and papilloedema resolved in both eyes. In 1 patient intracranial pressure monitoring revealed raised pressure preoperatively with no significant change in the first 24 hours after surgery. We conclude that optic nerve decompression is effective in the treatment of benign intracranial hypertension, has its effect locally, and in some patients may lower the intracranial pressure.

Adult↗
PubMed1981

Progressive multifocal leukoencephalopathy.

Three cases of progressive multifocal leukoencephalopathy have occurred in one hospital in a 3-year period. The 3 patients had been receiving chemotherapy for chronic myeloid leukaemia, lymphocytic lymphoma and acute myeloid leukaemia respectively, and developed progressive neurological illnesses which resulted in their deaths. The routine neurological investigations were unhelpful and although the diagnosis was suspected in 2 cases, treatment was not given. It is felt that the disease is not as rare as originally believed and that brain biopsy should be more readily considered since progressive multifocal leukoencephalopathy is potentially treatable.

Astrocytes↗
PubMed1979

The effects of changes in the body-weight of cows on the composition of their milk.

Ninety-six cows (48 Ayrshires and 48 Friesians) were weighed at seven day intervals. Forty-six cows gained weight and showed significant average increases in milk yield and solids-not-fat (SNF) percentage and non-significant rises in protein percentage and freezing point. The fat percentage was significantly lowered. The other 50 cows lost weight and a significant drop in SNF percentage was recorded. The other parameters showed non-significant falls.

Animal Feed↗
PubMed1978

Cell counts and composition of bovine milk.

Observations were made on 249 first or second calf heifers in which mastitis had been diagnosed in a mammary quarter which was opposite a normal quarter. Cell counts were made on the milk from each quarter and the cows were divided into three groups with the infected quarters classed according to the cell count. The infected quarters gave lower yields of milk with lower fat, solids-not-fat (SNF) and protein percentages than the opposite normal quarters in all three groups, but the differences between the means were only significant in yield and fat and SNF contents in the two groups with cell counts of over 500,000 per ml. In 175 animals the numbers and diameters of the fat globules were measured. The only significant reduction was in the globule numbers in the cows with from 1 to 2 million globules per ml of milk.

Animals↗
PubMed1978

The effects of visiting parties on milk production in cows.

Observations were made at the evening milkings on the day before and immediately after 131 cows housed and milked in cowsheds had been disturbed by parties of visitors. The cows were divided into three groups according to the extent of the reduction in milk yield following the visits. In the two groups showing the greatest differences the disturbances significantly reduced the fat and solids-not-fat (SNF) percentages and raised the milk cell counts.

Animals↗
PubMed1977

The effect of oestrus on milk production in cows.

The rectal temperatures, pulse rates and milk yields of 44 Ayrshire and 38 Friesian cows were recorded during oestrus and compared with values obtained after oestrus had ceased. The fat, solids-non-fat (SNF) and protein percentages and the cell counts of milk samples were also compared. Forty of the cows were housed in cubicles and 42 were kept loose in yards. During oestrus rectal temperatures and pulse rates were significantly raised and milk yields were lowered. Milk had, on average, significantly higher fat contents and cell counts and lower SNF and protein contents than post-oestrous milk. The differences due to oestrus between the cows kept in cubicles and yards were minimal, but the Ayrshire cows tended to show more significant effects than the Friesians, except in the milk cell counts, where the difference was higher in the Friesians.

Animals↗
PubMed1976

The effect of disturbances on milk production in cows.

Observations were made at the evening and morning milkings immediately before, and the corresponding milkings immediately after, cows had either been injected with tuberculin or disturbed by parties of visitors. At the evening milkings both types of disturbance reduced yield and solids-not-fat (SNF) and protein percentages, but the tuberculin tests increased, and the party visits decreased, the fat percentages. For all these parameters compensatory opposite results were obtained at the milkings the following mornings.

Animals↗
PubMed1975

The feeding of copper sulphate to ducklings.

1. Aylesbury ducklings, from 8 to 63 d of age, were fed on diets with or without supplemental copper (100 mg/kg). 2. Copper resulted in significant increases in growth rate and significantly smaller caeca both as a proportion of body weight and as the weight of unit length.

Animal Feed↗