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Biomedical subjects

J O Lawson

Publications and source records attributed to J O Lawson.

15 recordsLinked to original sources
PubMed1992

Diethylene glycol poisoning in Nigerian children.

Between June and September 1990, 47 children died at Jos University Teaching Hospital, Nigeria from ingestion of paracetamol syrup adulterated with diethylene glycol. Most of the children presented with anuria, fever, vomiting, diarrhoea and convulsions. Signs on admission were tachycardia, acidotic breathing, pallor, oedema and hepatomegaly. Laboratory findings included hyperkalaemia, acidosis, elevated creatinine level and hypoglycaemia. Management consisted of correction of dehydration and acidosis plus administration of antibiotics when indicated. None of the children had dialysis. All died within 2 weeks of admission. Proper government supervision of pharmaceutical companies and their agencies is urgently needed in order to prevent any future occurrence of such tragic deaths.

Acetaminophen↗
PubMed1989

Neonatal hydrometrocolpos.

A neonate with persistence of the urogenital sinus, double vaginae and hydrometrocolpos, in association with an anterior perineal anus, ambiguous genitalia and a ventricular septal defect, is described. Abdominal ultrasound led to an early diagnosis which prevented morbidity and mortality from renal failure and unnecessary laparotomy. Drainage was achieved by a perineal procedure.

Female↗
PubMed1986

Suction biopsy in Hirschsprung's disease.

Seventy two children with symptoms and signs consistent with Hirschsprung's disease had full thickness and suction rectal biopsies performed. Results were identical with both methods, except for one case of total aganglionosis of the colon. Full thickness biopsy no longer has a place as a screening method.

Adolescent↗
PubMed1985

Clinical evaluation of the histochemical diagnosis of Hirschsprung's disease.

The histochemical staining of suction rectal biopsies for acetylcholinesterase (AChE) activity is a safe and accurate diagnostic tool in the management of patients with symptoms and signs of Hirschsprung's disease. In this study 101 patients who have undergone AChE analysis of suction rectal biopsies are presented in order to correlate histochemical findings with subsequent clinical course after a minimum of 18 months follow up. There were no false positive results, but the limitations and problems associated with the technique which we have encountered are discussed. Equivocal, atypical, or negative results when contradicting clinical features are indications for repeat biopsy or full thickness biopsy, and awareness of the situations in which false negative results may occur is essential.

Acetylcholinesterase↗
PubMed1976

Investigation and management of long-standing chronic constipation in childhood.

The anorectal physiology of 106 children with long-standing chronic constipation, who had failed to response to a trial of medical treatment, was assessed. 10 (9%) were shown to have ultrashort-segment Hischsprung's disease, later confirmed on histology, The remainder showed evidence of hypertrophy of the internal sphicter on anorectal manometry and had a vigorous anal dilatation (to accept 4 fingers) under general anesthesia. After this, 38% were able to be weaned off all medication and most of the remainder improved. Further anal dilatation and internal sphincterotomy allowed a further 10 children to stop laxative, bringing the total to 48%.

Adolescent↗