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Biomedical subjects

J O Mullen

Publications and source records attributed to J O Mullen.

8 recordsLinked to original sources

Hip fracture mortality. A prospective, multifactorial study to predict and minimize death risk.

Four hundred consecutive hip fractures were studied prospectively. Two hundred forty-seven patients were classified as unhealthy (poor cardiac status, pneumonia, cancer history, bowel obstruction history, malnutrition, dehydration, stroke history, renal failure history, cirrhosis). Twenty-two percent of this unhealthy group died, while only 6% of the remaining healthy group died. Death rates varied with admission activity level and mental status but not when patient health status was factored out. After factoring out health status, age was associated with higher death rates only in patients older than age 85. Confusion, a change of mental status in the hospital, occurred in 25% of patients. Confusion was associated with a medical complication in 94% of cases, was the presenting symptom of a medical complication in 79% of cases, and was associated with a 39% death rate. Major medical complications occurred in 9% of the healthy group (29% of them died) and 21% of the unhealthy group (64% of them died). Major medical complications in unhealthy, shut-in patients were associated with an 80% death rate. Vigorous urinary tract monitoring and early treatment of bacteriuria decreased death rate. Postfracture malnutrition was associated with higher complication rates. Hip surgery performed within 72 hours on patients with acute medical illnesses in addition to their fracture was associated with a higher death rate. Whether a patient walked postfracture seemed not to be correlated with the death rate. Patients who were not walking prefracture but treated by internal fixation had a 34% failure rate.

Age Factors↗

Congenital pseudarthrosis of the tibia associated with cleidocranial dysostosis and osteogenesis imperfecta. A case report.

A neonatal boy with cleidocranial dysostosis presented with congenital pseudarthrosis of the tibia. Clinical observation later revealed he also had osteogenesis imperfecta. The osteogenesis imperfecta was classified as Type I and the congenital tibial pseudarthrosis as Type II. Cleidocranial dysostosis, osteogenesis imperfecta, and congenital pseudarthrosis of the tibia have not been previously reported to coexist in one individual.

Abnormalities, Multiple↗

Renal hypophosphatemic osteomalacia unmasked by hyperthyroidism.

A case of renal hypophosphatemic osteomalacia (RHO) that was unmasked by hyperthyroidism is presented. The patient presented at age 64 with pathologic leg fractures. There was no family history of osteomalacia or rickets. Initial evaluation revealed hyperthyroidism, which was treated with radioactive iodine. Despite control of thyroid function, the patient had recurrent pathologic fractures. Further evaluation revealed histologically proven osteomalacia and the biochemical findings of RHO: elevated serum alkaline phosphatase, decreased serum phosphate and tubular resorption of phosphate, and normal serum calcium, parathyroid hormone, and vitamin D levels. Other causes of osteomalacia were excluded. Treatment with phosphate and calcitriol reversed the osteomalacia. This case demonstrates that hyperthyroidism, and possibly other illnesses that affect vitamin D or bone metabolism, may unmask metabolic bone disease and that physicians should be alert for the subtle clinical and biochemical indicators of unrecognized metabolic bone disease in adults.

Bone and Bones↗

A simplified technique for Zickel nail insertion.

The Zickel nail can be inserted without difficulty as follows. The fracture table is set for the supine position and double-leg traction. Adduction of the fractured leg and traction on the opposite abducted leg clear the femur from the iliac wing. With use of the image intensifier for blind insertion of an intramedullary rod, the Zickel nail can be inserted without fracture site exposure. This technique reduces operative time from several hours to 48 minutes +/- 25 minutes and blood loss from several units to 325 cc +/- 150 cc.

Bone Nails↗

Range of motion following total knee arthroplasty in ankylosed joints.

Following a vigorous range of motion protocol, 13 ankylosed knees (preoperative motion, 16 degrees +/- 8 degrees to 48 degrees +/- 23 degrees) achieved a significant increase in postoperative range of motion (0 degree +/- 2 degrees to 103 degrees +/- 20 degrees), which was indistinguishable from that achieved by a comparable group of flexible knees (preoperative flexion, 90 degrees or more). The motion gained has been sustained during the two- to five-year follow-up period of the study.

Ankylosis↗