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J Oetiker

Publications and source records attributed to J Oetiker.

3 recordsLinked to original sources

[Prévot nailing, an elegant method. Experiences with 38 personal cases].

Endomedullar elastic stabilization with titanium Prévot nails is an excellent method of treating long-bone fractures in children. Without touching the epiphyseal line, this method guarantees early functional follow-up treatment with minimal operative trauma. For this reason, this method can compete successfully with common methods like extension treatment, external fixation and osteosynthesis with plates. From October 1990 to October 1993 we treated more than 40 fractures with Prévot nails and checked 38 of them clinically and radiologically. All 17 femur fractures healed correctly from an anatomical point of view and without rotation defects. In 4 patients we found a maximum difference in length of 1 cm in favor of the operated side. All of the 11 forearm fracture had good results, but there were 2 poor results with delayed union (adult patients) in the 6 humerus fractures operated upon. The remaining 4 cases, had to do with exceptional indications like lower leg fractures, combined humerus and forearm diaphyseal fractures, and metacarpal diaphyseal fractures. Our first experience with this method is good. The duration of hospitalization is short and early functional follow-up treatment for pediatric diaphyseal fractures is in general practicable. This procedure for operative care of femur and forearm diaphyseal fractures has now become the standard therapy in our clinic.

Bone Nails↗

LE-ACS4, a fruit ripening and wound-induced 1-aminocyclopropane-1-carboxylate synthase gene of tomato (Lycopersicon esculentum). Expression in Escherichia coli, structural characterization, expression characteristics, and phylogenetic analysis.

ACC (1-aminocyclopropane-1-carboxylic acid) synthase is the key regulatory enzyme in the biosynthetic pathway of the plant hormone ethylene and is encoded by a highly divergent multigene family in tomato (Rottmann, W. H., Peter, G. F., Oeller, P. W., Keller, J. A., Shen, N. F., Nagy, B. P., Taylor, L. P., Campbell, A. D., and Theologis, A. (1991) J. Mol. Biol. 222, 937-961). Two members of the family, LE-ACS2 and LE-ACS4, are induced during fruit ripening and upon treatment of mature green fruits with exogenous ethylene (C2H4) in a dose-dependent manner. Both genes are superinduced by wounding of pericarp tissue during various stages of ripening. The wound-induced accumulation of LE-ACS2 mRNA is more rapid and greater than that of LE-ACS4. Both mRNAs accumulate in the absence of protein synthesis, suggesting that their induction is a primary response to the inducer. The LE-ACS4 gene was isolated and structurally characterized. The function of the LE-ACS4 protein (53,509 Da, pI 5.4) was verified by expression experiments in Escherichia coli. The promoters of LE-ACS2 and LE-ACS4 contain potential cis-acting regulatory elements responsible for induction by ethylene, wounding, and anaerobiosis. In addition, elements for binding the transcriptional factors EmBP1, GBF-1, and OCSBF-1 are also present. Phylogenetic analysis of 20 ACC synthases from dicots and monocots indicate that the LE-ACS2 and LE-ACS4 proteins belong to an unique sublineage that includes an additional member of the tobacco family, NT-ACS1. The divergence of this sublineage is a relatively recent event in the evolution of ACC synthase protein.

Amino Acid Sequence↗