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Biomedical subjects

J Ollikainen

Publications and source records attributed to J Ollikainen.

10 recordsLinked to original sources
PubMed2004

Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration.

Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures. IL-6 levels were increased after seizures, whereas sIL-6R levels were decreased. Interestingly, the levels of IL-6 were strongly increased after recurrent generalized tonic-clonic seizures (GTCS), whereas after single tonic-clonic or prolonged partial seizures IL-6 levels were increased to lesser extent. These results provide further support for a hypothesis of cytokine production induced by seizure activity per se.

Antigens, CD↗
PubMed2001

Chronic lung disease of the newborn is not associated with Ureaplasma urealyticum.

To clarify the association of Ureaplasma urealyticum infection with chronic lung disease of the newborn 145 preterm infants less than 34 weeks of gestation were examined. The infants were enrolled during two separate periods. The presence of U. urealyticum was studied by obtaining endotracheal culture samples and blood samples; if either of these samples grew the organism, the child was regarded as having U. urealyticum infection. Infection with U. urealyticum was detected in 33%, and chronic lung disease (defined as the need for oxygen, and typical chest radiograph at 28 days of age) in 43% of infants. The development of chronic lung disease was not associated with the presence of U. urealyticum. Our results suggest only a minor indirect role for U. urealyticum in the development of chronic lung disease of the newborn.

Chronic Disease↗
PubMed2000

Perinatal Ureaplasma urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants.

To explore the association of perinatal Ureaplasma urealyticum infection and the need for hospital care during infancy, a cohort of preterm infants were prospectively followed for 12 months. Perinatal U. urealyticum infection was defined as the presence of U. urealyticum in the samples obtained from the trachea and blood. During the first year of life, the infants of the study cohort required 73 hospital admissions resulting in 734 hospital days. The 22 infants with perinatal U. urealyticum infection needed more hospital days for therapy than the 18 infants without infection (546 vs. 188 days, P = 0.042). The difference was caused by an increase in respiratory tract diseases among children with perinatal U. urealyticum infection. Chronic lung disease caused more admissions in infants with perinatal U. Urealyticum infection than without it (P = 0.035). The results indicate that perinatal U. urealyticum infection affects the health of premature infants far beyond the perinatal period.

Cohort Studies↗
PubMed2000

Reversible posterior leukoencephalopathy after combination chemotherapy.

We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MRI findings. Diffusion-weighted images during the first days after the onset of symptoms predicted a small irreversible lesion in the frontal lobe, verified on T2-weighted images 1 month later. The patient showed full recovery after high-dose steroid treatment.

Adolescent↗
PubMed1998

Clinical relevance of Ureaplasma urealyticum colonization in preterm infants.

A cohort of 78 infants of gestational age less than 34 weeks was examined for Ureaplasma urealyticum colonization and neonatal morbidity. Ureaplasma urealyticum was cultured from nasopharyngeal, endotracheal and blood-culture samples. A child was considered as being colonized if any sample was positive. The children with perinatal U. urealyticum colonization (n = 11; 14%) differed from those with no colonization (n = 67) in two important aspects: (i) they had higher leucocyte counts on the first (18.6 vs 12.4 10(9)) and the second (29.0 vs 15.4 10(9)) days of life (p = 0.01, both days); and (ii) they more often needed high-frequency oscillatory ventilation (45% vs 13%, p = 0.02). This study showed that U. urealyticum colonization is associated with signs of the host defence response together with symptoms of respiratory tract involvement suggesting the pathogenicity of U. urealyticum in premature infants.

Exudates and Transudates↗
PubMed1993

Ureaplasma urealyticum infection associated with acute respiratory insufficiency and death in premature infants.

The incidence and outcome of Ureaplasma urealyticum infection were studied in 98 infants born before 34 weeks of gestational age. Infection was defined as the presence of one or more isolations of U. urealyticum in samples obtained from trachea, blood, cerebrospinal fluid, or postmortem brain or lung biopsies. Forty-seven infants were infected. Intact amniotic membranes had no protective effect against infection; intrauterine U. urealyticum infection was detected in 19 infants who were born by cesarean section with intact amniotic membranes. Respiratory distress syndrome, the need for assisted ventilation, severe respiratory insufficiency, and death were significantly more common among infected than among noninfected infants. Our results suggest that U. urealyticum infection is associated with an unfavorable short-term outcome in preterm infants.

Humans↗
PubMed1993

A new platelet alloantigen, Tua, on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia in two families.

We describe immunization of two mothers against a new platelet alloantigen, designated Tua, in association with thrombocytopenia in their first born children. The platelet-specific antibodies were identified by a glycoprotein-specific platelet protein assay with husband's platelets. Monoclonal antibodies against glycoprotein complex IIb/IIIa (AP2) and against glycoprotein IIb (SZ22) could be used to immobilize the antigen bearing protein. When monoclonal antibodies against glycoprotein Ib/IX (FMC25) or Ia/IIa (Gi9) were used, no platelet-specific antibodies were detectable. The previously described alloantigens on the glycoprotein IIb/IIIa complex (HPA 1,3,4, Sra and Vaa) were not responsible for the reaction. Immunochemical analysis by an immunoblot assay showed that the Tua antigen resides on GPIIIa but the antigen was destroyed by reduction of the protein. Altogether 10 individuals belonging to three unrelated families were shown to carry the antigen. The family studies within three generations indicated autosomal codominant inheritance. Thus the Tua antigen is apparently different from all previously published platelet alloantigens. One Tua positive blood donor was identified in a population study of approximately 150 individuals. This indicates a low frequency in the Finnish population. Extended population studies will be required to determine a more exact frequency of Tua antigen.

Adult↗
PubMed1993

Ureaplasma urealyticum cultured from brain tissue of preterm twins who died of intraventricular hemorrhage.

We present a case of premature twins, born at 24 weeks of gestation. Both infants died of intraventricular hemorrhage, aged 1 and 3 days, respectively. Ureaplasma urealyticum was isolated from brain tissue obtained at the autopsy of both infants. Our observations lend additional evidence of the role of U. urealyticum as a central nervous system pathogen in premature infants.

Brain↗
PubMed1992

Hydrops fetalis associated with Ureaplasma urealyticum.

A hydroptic newborn was born at 32 weeks' gestation and at the age of 14 h died of post-asphyxial syndrome. Immunologic causes of hydrops fetalis were excluded, as were anomalies and chromosomal aberrations. Ureaplasma urealyticum was isolated in bronchial secretions, lung tissue and brain tissue of the newborn. Our findings suggest that U. urealyticum infection should be considered in the differential diagnosis of hydrops fetalis.

Brain Diseases↗