Biomedical subjects

J Ordi Ros

Publications and source records attributed to J Ordi Ros.

At least 19 recordsLinked to original sources

PubMed1996

[Pulmonary thromboendarterectomy in a patient with primary antiphospholipid syndrome].

Pulmonary arterial hypertension (PAH) is an infrequent manifestation of the primary antiphospholipid syndrome (PAPS). It may appear due to different mechanisms although the most common cause is recurrent pulmonary embolisms. In some cases the thrombi do not dissolve and organize to form fibrous masses which occlude the pulmonary veins giving place to chronic thromboembolic pulmonary hypertension. When the thrombi are located in the proximal arteries, thromboendarterectomy may be curative. The first case of a patient with PAPS diagnosed with PAH secondary to chronic thrombosis of the proximal pulmonary arteries, in whom a successful pulmonary thromboendarterectomy was performed is herein reported.

Adult↗

PubMed1995

[Anti-beta 2 glycoprotein I antibodies. Relationship with antiphospholipid antibodies and thrombosis].

BACKGROUND: Anti-beta 2-glycoprotein I antibodies (a beta 2GPI) were studied in patients with diseases or clinical symptoms related to antiphospholipid antibodies (aPl) with the aim of establishing a relationship between both antibodies and these clinical manifestations. METHODS: The a beta 2GPI antibodies were determined by enzymeimmunoassay in a group of 94 altruist blood donors and 135 patients (98 with systemic lupus erythematosus, 21 cases of primary antiphospholipid syndrome, 10 cases with idiopathic Sneddon syndrome and 6 with Q fever). The lupus anticoagulating-type aPl antibodies were determined in the same subjects by kaolin coagulation time and the Russell's viper venom time while anticardiolipin-type IgG, IgM and IgA isotypes were determined by enzymeimmunoassay. The a beta 2GPI antibodies were related with the aPl antibodies, fetal losses and history of thrombosis by a contingency table with Yates correction in the first two parameters and means comparison by the Students' t test for the history of thrombosis. RESULTS: The aPl and a beta 2GPI antibodies in the control group were negative. In the group of patients the latter antibodies were positive in 33.6% (33 cases) of the patients with lupus, 57% (12 cases) of the patients with primary antiphospholipid syndrome, in one of the patients with the Sneddon syndrome and in none of the patients with Q fever. The aPl antibodies were positive in 26.5% of the patients with lupus and in 100% of the cases with primary antiphospholipid syndrome or Q fever and negative in all the cases with idiopathic Sneddon syndrome. A significant relationship was found between the a beta 2GPI antibodies and thrombotic manifestations (p = 0.01) or obstetric complications (p < 0.04). A dependent relationship was observed in both autoantibodies (aPl and a beta 2GPI) (p < 0.01). CONCLUSIONS: There is a significant relationship between the antiphospholipid antibodies and the anti-beta 2-glycoprotein I antibodies in addition to a relationship with thrombotic symptoms or obstetric complications.

Adolescent↗

PubMed1995

[Recurrent bronchiolitis obliterans organizing pneumonia as first manifestation of polymyositis].

The case of an idiopathic polymyositis preceded by several episodes compatible with the diagnosis of bronchiolitis obliterans organizing pneumonia is herein reported. This kind of pulmonary affection in polymyositis can be simultaneous or later to the diagnosis of the systemic disease, but as the first manifestation is exceptional. In the case we report, paradoxically, when the diagnosis of polymyositis was made the patient had not clinical or radiographic bronchopulmonary affection. If the first clinical manifestation of an autoimmune disease like polymyositis can be an idiopathic bronchiolitis obliterans organizing pneumonia, we think that a prolonged follow up of these patients is necessary.

Anti-Inflammatory Agents↗

PubMed1994

[Coronary thrombosis as the manifestation of the antiphospholipid syndrome].

We present 3 cases of antiphospholipid syndrome with thrombosis in the coronary circulation. Two of them presented an acute myocardial infarction, whereas the third one showed thrombosis in the coronary microcirculation together with aortic valve disease.

Adult↗

PubMed1993

[Do new treatments contribute to improve the prognosis in systemic lupus erythematosus?].

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Humans↗

PubMed1990

[False positive serological tests for Borrelia burgdorferi in patients with primary antiphospholipid syndrome].

Serological tests for Borrelia burgdorferi were carried out in a series of 27 patients with primary antiphospholipid syndrome (PAPLS). The results showed a 14% prevalence of false positive Lyme disease serology in this patient population. In patients with PAPLS and false positive serologic tests for Borrelia burgdorferi neurological involvement was significantly more common (p = 0.012, Fisher's exact test) than in patients with PAPLS without that finding. We insist on the possibility that patients with PAPLS may have false positive serological tests for Borrelia burgdorferi as measured by IFI with the resulting diagnostic error. In these cases, confirmation by other techniques such as ELISA or immunoblotting is recommended.

Adult↗

PubMed1990