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Biomedical subjects

J Ormos

Publications and source records attributed to J Ormos.

At least 19 recordsLinked to original sources
PubMed1992

[Simultaneous occurrence of persistent hematuria (thin basement membrane nephropathy) and light-chain proteinuria (benign monoclonal gammopathy) in a middle-aged male].

IgG lambda type of monoclonal gammopathy and thin basement membrane nephropathy were established in a middle-aged man examined because of persistent haematuria, lambda light-chain proteinuria and moderately diminished renal function. A 10% level of plasmocytosis was verified by bone-marrow aspiration. The more than 6-year follow-up showed the gammopathy to be benign. The thin basement membrane nephropathy was verified by electronmicroscopic analysis of renal tissue obtained by percutaneous renal biopsy: lamina densa of the glomerular capillaries thinned to 30-100 nm. In spite of the usually good outcome of thin basement membrane nephropathy, in this case it was accompanied by glomerular sclerosis, subsequent destruction of nephrons, hypertensive vascular alterations and a clinical deterioration of the renal function after 4 years. A rebiopsy excluded the possible complications (amyloidosis, non-amyloid immunoglobulin nephropathy, cylinder nephropathy, etc) of light-chain proteinuria.

Adult↗
PubMed1992

Hereditary nephritis, platelet disorders and deafness-Epstein's syndrome.

A 14-year-old boy with persistent proteinuria (1.6-4.0 g/day), microscopic haematuria, moderate hypertension, macrothrombocytopenia (giant platelets, platelet number 30 x 10(9)/l) and a familial sensorineural hearing loss (the father and the brother were also affected) was studied. Kidney biopsy revealed a diffuse mesangial proliferation, and a focal thickening of the glomerular basement membrane was seen on electron microscopy. A normal number of megakaryocytes was observed in bone marrow aspirates. The aggregation response of the platelets to collagen, epinephrine and adenosine diphosphate (ADP) was decreased. The platelet number was slightly diminished, platelets were of normal size in both parents and the brother, and showed a decreased aggregability in response to collagen, epinephrine and ADP in the brother and mother. No functional abnormality of the platelets was observed in the father. Urinalysis and kidney function were normal in the family members. This boy with nephritis, platelet disorders and hearing loss corresponds to Epstein's syndrome.

Adolescent↗
PubMed1979

Renal cortical tubules in experimental malakoplakia. Phagocytic alteration of tubular epithelium.

Intrarenal injection of a crude E. coli extract (endotoxin-antigen-complex) induced malakoplakia in rats. Beside the granulation tissue the proximal tubular epithelium showed a strong phagolysosomal response--especially in two-three weeks--, thus becoming very similar to the Hansemann cells of the malakoplakia granulation tissue. This malakoplakia alteration of the epithelium if very severe sometimes led to necrosis or it was segregated inside the epithelial cells. Later on an atrophy of the tubules developed similar to the atrophy of different etiology, but the remaining cells often contained a striking number of residual bodies. It is suggested that the tubular granulated cells of megalocytic interstitial nephritis regarded as identical with renal cortical malakoplakia also have a tubular epithelial origin.

Acid Phosphatase↗
PubMed1979

[Transformation of the epithelial cells of the kidney tubules in experimental malacoplakia].

As an effect of administration of the extract of E. coli in the kidney of rats phagolysosomal reaction has been observed, not only in the granulomatous tissue characteristic of malacoplakia, but in the epithelial cells of the proximal tubules. The latter became similar to the histiocytes of malacoplakis i.e. Hansemann's cells. The transformation of the tubular epithelium in severe cases of malacoplakia was followed by necrosis. In a later phase tubular atrophy came into being, which did not differ from the atrophy caused by other agents, although epithelial cells contained numerous residual body. Authors believe, that granular tubular cells of megalocytic interstitial nephritis--regarded as malacoplakia of the renal cortex--originate from tubular epithelium.

Animals↗
PubMed1979

[Regeneration of the proximal kidney tubules after sublimate-induced necrosis in the rate. Scanning electron microscopic studies].

Necrosis of the proximal tubules of the kidney in white rats has been produced by a relative small doses (1,5 mg/kg) of sublimate. Necrosis of the epithelial cells and their regeneration was studied during 10 days by scanning electron microscopy. Parallelism of the various regressive and regenerative processes was noted, attention was paid to the correlation existing between them. Periodicity of normal and necrotic segments was also observed. As a sequal of the necrosis the basement membranes became denuded, later in the first period of the regeneration flattened epithelial cells--having no microvilluses--covered them. On the surface of the latter, in a very short period (several hours) gradually microvilluses, regular brush-border and interdigitation of the cells were formed. In 10-17 days the regenerated epithelium could hardly be distinguished by scanning electron microscopy from the normal one.

Acute Kidney Injury↗
PubMed1979

Regeneration of proximal tubules of the rat kidney following sublimate necrosis. A scanning electron microscopic study.

Necrosis of the proximal tubules of the rat kidney was induced by low (1.5 mg/kg) doses of sublimate. Epithelial necrosis and regeneration were followed by scanning electron microscopy for 10 days. Regressive and regenerative processes were observed simultaneously. The naked basement membrane is first invaded by flat epithelial cells lacking microvilli. Within a few hours microvilli appear followed by the formation of regular brush-border and interdigitations cells. After 7--10 days the newly formed epithelium cannot be distinguished from the intact one.

Animals↗
PubMed1979

Histochemical studies on peroxisomes in regenerating proximal tubules of the kidney.

Peroxisomes of the regenerating proximal tubules of the rat kidney were investigated after necrosis induced by mercuric chloride. Slices both for light and electron microscopic examinations were incubated in 3,3'-diaminobenzidine (DAB) medium. Peroxisomes were absent in the necrotic epithelium. They appeared on the fourth day of regeneration and later their number increased reaching the normal distribution in the fourth week. They seem to be needed for the functional differentiation of the proximal tubule cells during regeneration.

Animals↗
PubMed1979

Urinary osmolarity in late stage nephritis and nephrosis.

Urinary osmolarity was studied with the DDAVP test in 30 children in the late stage of glomerulonephritis or nephrosis syndrome, and in 12 control children. A restriction of the concentrating ability of the kidney was demonstrated in the cases accompanied by residual symptoms, in comparison to the healthy children and to the patients in lasting remission. In the cases examined histologically, tubular damage corresponding to the functional change could be demonstrated.

Adolescent↗
PubMed1978

[X-ray microanalysis of Michaelis-Gutmann bodies with the use of EDAX].

X-ray microanalysis of Michaelis--Gutmann bodies in human malakoplakia (kidney and testes) and in that of rats induced experimentally by administration of endotoxin of Escherichia coli, was carried out. The presence of calcium could be revealed in every Michaelis--Gutmann body according to the lines of Kalfa and K3 as well. The amount of it was in correlation with the stage of the calcification. In the Michaelis--Gutmann bodies found in the rat kidney, fixed without OsO4 presence of P could also be demonstrated. The correlation between the weight per cent of Ca and P seems to evidence the presence of CaHPO4. Results of the X-ray microanalysis of Michaelis--Gutmann bodies found in human and in experimentally induced malakoplakia appeared to be similar.

Antitoxins↗
PubMed1978

X-ray microprobe analysis of Michaelis-Gutmann bodies in human and experimental malakoplakia.

Using x-ray microprobe analysis, we studied Michaelis-Gutmann bodies (M-G bodies) in malakoplakia tissue samples from human kidney and testis as well as from lesions experimentally induced in the rat. In all the M-G bodies tested we could unambiguously detect calcium at both its Kalpha and Kbeta lines. The actual amount of calcium depended on the developmental state, ie, on the degree of calcification of the M-G body, In M-G bodies of rat kidney malakoplakia tissue fixed without osmium tetroxide, the phosphorus could also be detected unambigously. From the ratios of calcium and phosphorus percentages (w/w) we concluded that CaHPO4 was present. No difference was found between M-G bodies in malakoplakia tissues of human origin and those in experimentally induced malakoplakia.

Animals↗
PubMed1977

Postmortem diagnostics of renal diseases from semithin sections.

For the light microscopic postmortem study of mostly glomerular renal diseases, in addition to the paraffin technique, 0.5 mu thick (semithin) sections from material fixed in buffered formaldehyde and embedded in methacrylate or Durcupan ACM were used. The method allows for eventual electron microscopic examinations. The semithin sections were stained with methylene blue combined with basic fuchsin, as well as with periodic acid-silver methamine. The method is not a substitution, but the supplementation of the paraffin technique and is suited for the clarification of numerous fine details: in some cases the exact diagnosis was made in this way.

Cytological Techniques↗
PubMed1977

[Ultrathin sections in postmortem morphological diagnosis of kidney diseases].

Authors for the light-microscopic examination of various--mainly glomerular--diseases of kidneys in addition to paraffin section have used also ultrathin sections (0,5 mu). Material was fixed in buffered-formalin solution and embedded in metacrylate or Durcupan ACM. Sections obtained by this method can be studied by electron micro-scope as well. Sections were stained with methylene-blue and basicfuchsine, further with periodic-acid silver methenamine. The use of ultrathin sections for the light-microscopic studies can not replace the study of paraffin-sections. Ultrathin sections are suitable for the detection of fine details. They can be studied by light- and electron microscopy as well.

Autopsy↗