Biomedical subjects
Publications and source records attributed to J P Agrawal.
A chemoselective reductive method has been achieved for the preparation of 4-picrylamino-2,6-dinitrotoluene (PADNT), a new insensitive energetic material which has been characterised by spectral data and elemental analysis. Some explosive properties of the compound have also been determined and the results indicate that PANDT is quite safe to impact and friction.
The importance of a prediction tool increases with greater relevance for synthesis, performance and vulnerability predictions. Some important aspects of performance behaviour and their theoretical calculations, which are indispensable in recognising energetic molecules of interest, are described here. This review also discusses on factors influencing sensitivity and overall stabilities of organic energetic compounds especially on nitroaromatics and nitramines, and exceptions to this relationship suggest other factors playing roles in specific instances.
3-Amino-5-nitro-1,2,4-triazole (ANTA) and its derivatives have been prepared in order to carry out the systematic studies on structural aspects, explosive and thermal behaviour. Thermal studies were carried out for ANTA and 4,6-bis-(3-amino-5-nitro-1H-1,2,4-triazole-1-yl)-5-nitropyrimidine (DANTNP) by thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimeter (DSC) and manometric thermal analysis. The results show that (DANTNP) is more thermally stable than ANTA when compared in terms of activation energy.
1-(2-Nitroxyethylnitramino)-2,4,6-trinitrobenzene (I-A), 1, 3-bis(2-nitroxyethylnitramino)-2,4,6-trinitrobenzene (II-A) and 1,3, 5-tris(2-nitroxyethylnitramino)-2,4,6-trinitrobenzene (III-A) have been prepared by condensing picryl chloride, styphnyl chloride and 1, 3,5-trichloro-2,4,6-trinitrobenzene with ethanol amine, respectively, followed by nitration. These compounds have been characterized by infrared spectrum (IR), the elemental analysis and 1H NMR. Further, these compounds have been studied for their thermal and explosive properties. The activation energy of thermal decomposition of these compounds has also been determined using the Ozawa and the Kissinger methods. The data on explosive properties indicate that the impact, friction and velocity of detonation (VOD) increase with an increase in the number of nitrate ester groups.
We report a case with progressive mental deterioration and persistent low grade fever, who was diagnosed to have cryptococcal meningitis. This case is unique in that the cryptococcal latex agglutination antigen test was consecutively negative. The diagnosis was made by sequential CSF culture.