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Biomedical subjects

J P Bailey

Publications and source records attributed to J P Bailey.

12 recordsLinked to original sources
PubMed1992

Synthesis and structure-activity relationships of cephalosporins with C-3' catechol-containing residues.

Cephalosporins with new catechol substituents at C-3' have been synthesized, including novel compounds with C-3' carbon-carbon bonds. Many of these compounds have high potency against Gram-negative bacteria, in particular against resistant strains like Pseudomonas aeruginosa. Structure-activity relationships are discussed in terms of their dependence on the pKa of the C-3' catechol and also in terms of steric and conformational factors of the C-3' substituent. The best overall properties were found in compounds with a bulky and/or conformationally restricted acidic C-3' catechol.

Animals↗
PubMed1991

Prospective randomized trial of sequential compression devices vs low-dose warfarin for deep venous thrombosis prophylaxis in total hip arthroplasty.

A prospective randomized trial compared the effectiveness of low-dose warfarin (LDW) to sequential compression devices (SCD) for deep venous thrombosis (DVT) prophylaxis in 95 patients after total hip arthroplasty (THA). Patients were 39 years of age or older, with no history of previous venous disease. Bilateral lower-extremity venography was used for thrombi detection. Venous thrombi occurred in 12 patients (all calf) on LDW (26.6%) and 3 patients with SCDs (one calf, two thigh) (6.0%). The incidence of DVT was significantly higher in the LDW group (P less than .006). In this study of average-risk patients, the use of SCDs significantly outperformed LDW as a prophylactic agent. However, the thrombi that did occur with SCDs were more critical.

Adult↗
PubMed1990

Diffuse nail dyschromia in black patients with systemic lupus erythematosus.

Diffuse dark blue-black chromonychia was observed in 17 of 33 (52%) black patients with systemic lupus erythematosus (SLE), but not in 47 non-SLE black patients. About half of these patients had active disease. A comparison was made between patients with SLE with chromonychia and those without but no distinctive clinical or laboratory variable differentiated the 2 groups. This pattern of nail hyperpigmentation has not previously been associated with SLE.

Adolescent↗
PubMed1978

Comparison of the vigilance performance of men and women using a simulated radar task.

The present study examined the question of possible sex differences in the ability to sustain attention to a complex monitoring task requiring only a detection response to critical stimulus changes. The visual display was designed to approximate a futuristic, highly automated air traffic control radar display containing computer-generated alphanumeric symbols. There were 26 men and 26 women tested, each over a 2-h session. Sixteen targets appeared on the screen at all times, with 10 signals (a designated change in the alphanumerics) randomly presented during each 0.5 h of the test session. Detection latency to the signals increased significantly during the session, but there was no evidence of any significant differences between the sexes in the magnitude or pattern of this increase. The results are discussed in terms of a general decline in alertness that was apparently equal for both sexes.

Adolescent↗
PubMed1976

Boredom and arousal: comparison of tasks differing in visual complexity.

This experiment was designed to examine the relationship of boredom to arousal. 32 male subjects participated, with 16 subjects performing a low-visual-complexity task and the remainder performing a task high in visual complexity. Both physiological and subjective measures were obtained. Responses to subjective questionnaires showed significant increases in boredom for both groups. Physiological measures indicated a mixed pattern of change. These results suggest a complex response pattern for the construct of boredom which cannot be described as clearly showing either increasing or decreasing arousal.

Adolescent↗
PubMed1975

Reactions to sonic booms: a report of two studies and a general evaluation of startle effects.

Two separate studies are reported. The first attempted to determine a sonic boom level below which startle would not occurr. Subjects were exposed indoors to six simulated sonic booms having outside overpressures of 50, 30, and 16 N/m-2 (inside levels of 74, 71, and 65 dBA). Approximately 20% of the subjects gave small arm-hand responses to the two higher exposure levels, while none responded to the lowest level. In the second study, subjects were exposed indoors to a series of 12 simulated booms in order to assess habituation effects. Outside overpressures were 130 and 50 N/m-2 (indoor levels of 81 and 72 dBA). Significant, but not complete, habituation occurred to booms of both levels. Autonomic and eyeblink responses, as well as ratings of annoyance, were obtained in both studies. The final section summarizes the expected behavioral, autonomic, and subjective effects of exposure to various levels of sonic booms.

Adaptation, Physiological↗